A5037071107- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- Chemotherapy-induced cardiotoxicity and mitigation
- Bioactive Compounds and Antitumor Agents
- Cell death mechanisms and regulation
- Click Chemistry and Applications
- Radiopharmaceutical Chemistry and Applications
- Boron Compounds in Chemistry
- Lung Cancer Research Studies
- Photochromic and Fluorescence Chemistry
- Cancer Research and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Synthesis and Catalytic Reactions
- PARP inhibition in cancer therapy
- Acute Myeloid Leukemia Research
- HIV/AIDS drug development and treatment
- Sulfur-Based Synthesis Techniques
- Biochemical and Molecular Research
- Electron Spin Resonance Studies
- Chemical Synthesis and Analysis
- X-ray Diffraction in Crystallography
- Synthesis and Reactions of Organic Compounds
- Ionic liquids properties and applications
- Fluorine in Organic Chemistry
- Advanced Drug Delivery Systems
Polish Academy of Sciences
2021-2025
Institute for Medical Biology
2021-2025
University of Łódź
2014-2018
iRobot (United States)
2016
Chiral sulfonamides with aromatic fragments are important chemical building blocks found widely in many natural products, catalysts, and molecules of biological importance. In this report, we describe the efficient synthesis a series chiral which, addition to part (phenyl, biphenyl, dansyl units), possess N-heterocyclic systems. The described compounds were obtained by nucleophilic substitution amines commercially available sulfonyl chlorides under mild conditions. All derivatives examined...
Sulfonylureas (SUs)-a class of drugs primarily used to treat type 2 diabetes-have recently attracted interest for their potential anticancer properties. While some studies have explored the chemical modification or design new SU derivatives, our work instead centers on biological evaluations all commercially available SUs in combination with doxorubicin (DOXO). These antidiabetic agents act by stimulating insulin secretion via KATP channel inhibition, and because channels share structural...
Abstract Synthesis of acridine derivatives that act as DNA‐targeting anticancer agents is an evolving field and has resulted in the introduction several drugs into clinical trials. Carboranes can be importance designing biologically active compounds due to their specific properties. Therefore, a series novel analogs modified with carborane clusters were synthesized. The DNA‐binding ability these was evaluated on calf thymus DNA (ct‐DNA). Results analyses showed 9‐[(1,7‐dicarba‐ closo...
The synthesis of carborane-1,8-naphthalimide conjugates and evaluation their DNA-binding ability anticancer activity were performed. A series 4-carboranyl-3-nitro-1,8-naphthalimide derivatives, mitonafide pinafide analogs, synthesised via amidation reductive amination reactions, calf thymus DNA (ct-DNA)-binding properties investigated using circular dichroism, UV–vis spectroscopy, thermal denaturation. Results showed that 34–37 interacted very strongly with ct-DNA (ΔTm = 10.00–13.00 °C),...
Starting with fluorinated benzylamines, a series of 2-unsubstituted imidazole N-oxides was prepared and subsequently deoxygenated in order to prepare the corresponding imidazoles. The latter were treated benzyl halides yielding imidazolium salts, which are considered analogues naturally occurring alkaloids known as lepidilines A C. second oxa-lepidiline obtained by O-benzylation initially synthetized N-oxides. Both salts tested anticancer antiviral agents. results demonstrated that...
In the current work, we present a broad analysis of cytotoxicity toward normal (kidney and lung) cancer (lung, liver, cervix) cells ionic liquids (ILs) with imidazolium cations cyano-based or bis(trifluoromethylsulfonyl)imide anions. Additionally, verify if ILs might be candidates for new potential virucidal agents. We observed highest biological activity 1-methyl-3-octylimidazolium bis(trifluoromethylsulfonyl)imide, whereas least toxic was 1-ethyl-3-methylimidazolium thiocyanate. found that...
Ovarian cancer is one of the most frequent and deadly gynaecological cancers, often resistant to platinum-based chemotherapy, current standard care. Halophilic microorganisms have been shown produce a large variety metabolites, some which show toxicity various cell lines. However, none yet be active against ovarian cells. Here, we examined effects metabolites secreted by halophilic archaea Halorhabdus rudnickae Natrinema salaciae on lines, including lines.1H NMR analyses Hrd. Nnm. culture...
In this study, the structural attributes of nanoparticles obtained by a renewable and non-immunogenic "inulinated" analog "pegylated" PLA (PEG-PLA) were examined, together with potential these novel nanocarriers in delivering poorly water-soluble drugs. Characterization INU-PLA assemblies, encompassing critical aggregation concentration (CAC), NMR, DLS, LDE, SEM analyses, was conducted to elucidate core/shell architecture carriers vitro cyto- hemo-compatibility assayed. The entrapment...
The purpose of this study was to provide a detailed explanation the mechanism bisanthracycline,?WP 631 in comparison doxorubicin (DOX), first generation anthracycline, currently most widely used pharmaceutical clinical oncology. Experiments were performed SKOV-3 ovarian cancer cells which are otherwise resistant standard drugs such as cis-platinum and adriamycin. As attention focused on ability WP induce apoptosis, examined using double staining method with Annexin V propidium iodide probes,...
2-Azabicycloalkanes: 2-azabicyclo[2.2.1]heptane and 2-azabicyclo[3.2.1]octane were used as a chiral platform for the construction of set 1,2,3-triazole, thiourea, ebselen derivatives. Cytotoxicity antiviral activity studies revealed most promising potency selected thioureas.
The study investigated the structure-activity relationship of newly synthesized dye-linker-macrocycle (DLM) conjugates and effect each component on various biological properties, including cytotoxicity, cellular uptake, intracellular localization, interaction with DNA photodynamic effects. were by combining 1,8-naphthalimide thioxanthone dyes 1,4,7,10-tetraazacyclododecane (cyclen) 1-aza-12-crown-4 (1A12C4) using alkyl linkers different lengths. results revealed significant differences in...
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
The study aimed to evaluate the cytotoxic activity of newly synthesized Dye-Linker-Macrocycle (DLM)type conjugates on both non-cancerous and cancerous cell lines investigate structure-activityrelationship. results revealed significant variations in among different conjugateseries, regardless type intercalating dye used, crown ether exhibited significantlyhigher cytotoxicity compared cyclic polyamine conjugates. conjugation dyes with crownethers proved be an effective strategy for improving...