A5034178990- Radiopharmaceutical Chemistry and Applications
- Boron Compounds in Chemistry
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Orthopedic Infections and Treatments
- Photochromic and Fluorescence Chemistry
- Click Chemistry and Applications
- Advanced biosensing and bioanalysis techniques
- Biochemical and Molecular Research
- Nanoplatforms for cancer theranostics
- Computational Drug Discovery Methods
- Infective Endocarditis Diagnosis and Management
- Boron and Carbon Nanomaterials Research
- Synthesis and Characterization of Heterocyclic Compounds
Institute for Medical Biology
2019-2024
Polish Academy of Sciences
2018-2024
This study presents the activity of a series 1,8-naphthalimide-carborane/metallacarborane conjugates against Rhabditis sp. The carborane were least active. Selected with cobaltacarborane (5 and 6) showed high activity. Their lethal concentration (LC50) values are substantially lower than that drug mebendazole.
Abstract Synthesis of acridine derivatives that act as DNA‐targeting anticancer agents is an evolving field and has resulted in the introduction several drugs into clinical trials. Carboranes can be importance designing biologically active compounds due to their specific properties. Therefore, a series novel analogs modified with carborane clusters were synthesized. The DNA‐binding ability these was evaluated on calf thymus DNA (ct‐DNA). Results analyses showed 9‐[(1,7‐dicarba‐ closo...
Tuberculosis (TB) is a severe infectious disease with high mortality and morbidity. The emergence of drug-resistant TB has increased the challenge to eliminate this disease. Isoniazid (INH) remains key effective component in therapeutic regimen recommended by World Health Organization (WHO). A series isoniazid-carborane derivatives containing 1,2-dicarba-closo-dodecaborane, 1,7-dicarba-closo-dodecaborane, 1,12-dicarba-closo-dodecaborane, or 7,8-dicarba-nido-undecaborate anion were...
The study investigated the structure-activity relationship of newly synthesized dye-linker-macrocycle (DLM) conjugates and effect each component on various biological properties, including cytotoxicity, cellular uptake, intracellular localization, interaction with DNA photodynamic effects. were by combining 1,8-naphthalimide thioxanthone dyes 1,4,7,10-tetraazacyclododecane (cyclen) 1-aza-12-crown-4 (1A12C4) using alkyl linkers different lengths. results revealed significant differences in...
The presented study depicts the synthesis of 11 carborane-thiazole conjugates with anticancer activity, as well an evaluation their biological activity inhibitors two enzymes: tyrosinase and 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). overexpression results in intracellular accumulation melanin can be observed melanoma. 11β-HSD1 elevation glucocorticoid levels has been associated aggravation metabolic disorders such II diabetes mellitus obesity. Recently, comorbidity melanomas is...
The study aimed to evaluate the cytotoxic activity of newly synthesized Dye-Linker-Macrocycle (DLM)type conjugates on both non-cancerous and cancerous cell lines investigate structure-activityrelationship. results revealed significant variations in among different conjugateseries, regardless type intercalating dye used, crown ether exhibited significantlyhigher cytotoxicity compared cyclic polyamine conjugates. conjugation dyes with crownethers proved be an effective strategy for improving...