A5072147361- Bacteriophages and microbial interactions
- Microbial infections and disease research
- Carbohydrate Chemistry and Synthesis
- Genomics and Phylogenetic Studies
- Infections and bacterial resistance
- Microbial Natural Products and Biosynthesis
- Enzyme Production and Characterization
- Antimicrobial Peptides and Activities
- Enterobacteriaceae and Cronobacter Research
- Polyamine Metabolism and Applications
- Microbial Community Ecology and Physiology
- Escherichia coli research studies
- Cancer-related Molecular Pathways
- Biochemical and Structural Characterization
- Bacterial Identification and Susceptibility Testing
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- Urinary Tract Infections Management
- Yersinia bacterium, plague, ectoparasites research
- Seaweed-derived Bioactive Compounds
- Antibiotic Resistance in Bacteria
- Clostridium difficile and Clostridium perfringens research
- Microbial Metabolism and Applications
- Gut microbiota and health
- Antimicrobial Resistance in Staphylococcus
University of Łódź
2010-2022
Czech Academy of Sciences, Institute of Microbiology
2012
Medical University of Lodz
2006
Catheter‐associated urinary tract infections (CAUTI) caused by Proteus mirabilis are very difficult to treat due the ability of biofilm formation and drug resistance these bacteria. The aim this study was assess antibiofilm activity phages develop phage cocktail combat P. strains. Planktonic forms biofilms 50 tested uropathogenic strains showed different sensitivity 13 used. Phages 39APmC32, 65APm2833 72APm5211 presenting strong were selected as components. cocktails similar or slightly...
The genus Proteus belongs to the Enterobacteriaceae family, where it is placed in tribe Proteeae, together with genera Morganella and Providencia. Currently, consists of five species: P. mirabilis, vulgaris, penneri, hauseri myxofaciens, as well three unnamed genomospecies. most defining characteristic bacteria a swarming phenomenon, multicellular differentiation process short rods elongated swarmer cells. It allows population migrate on solid surface. inhabit environment are also present...
Urinary tract infections (UTIs) caused by P. mirabilis are difficult to cure because of the increasing antimicrobial resistance these bacteria. Phage therapy is proposed as an alternative infection treatment. The aim this study was isolate and differentiate uropathogenic strain specific polyvalent bacteriophages producing polysaccharide depolymerases (PDs). 51 phages were obtained. plaques 29 surrounded halos, which indicated that they produced PDs. host range analysis showed that, except...
Bacteriophage therapy has emerged as a strategy supplementing traditional disinfection protocols to fight biofilms. The aim of the study was isolate phages against E. faecalis and characterize its biological features, morphology, lytic activity in formed biofilm model. Methods: ATCC 29212 strain used for trial. Two novel vB_Efa29212_2e vB_Efa29212_3e virulent were isolated from urban wastewater characterized. established 15 bovine teeth 21 days. Transmission (TEM) scanning electron (SEM)...
Lung cancer is still the leading cause of cancer-related death worldwide, indicating a necessity to develop more effective therapy. Acridine derivatives are potential anticancer agents due their ability intercalate DNA as well inhibit enzymes involved in replication and transcription. Recently, we have evaluated activity 32 novel acridine-based compounds. We found that most were tetrahydroacridine cyclopentaquinoline with fluorobenzoic acid containing eight nine carbon atoms aliphatic chain....
The studies on phage therapy have shown an overall protective effect of phages in bacterial infections, thus providing optimistic outlook the future benefits phage-based technologies for treating diseases. However, therapeutic is highly affected by proper composition cocktails. rational approach to design bacteriophage cocktails, which subject this study, allowed development effective anti-mastitis solution, composed virulent bacteriophages acting Escherichia coli and Staphylococcus aureus....
Modification of outer membrane proteins (OMPs) is the first line Gram-negative bacteria defence against antimicrobials. Here we point to Proteus mirabilis OMPs and their role in antibiotic phage resistance. Protein profiles amikacin (AMKrsv), (Brsv) amikacin/phage (AMK/Brsv) resistant variants P. were compared that obtained for a wild strain. In there identified 14, 1, 5 overexpressed 13, 5, 1 downregulated AMKrsv, Brsv AMK/Brsv, respectively. Application phages with led reducing number up-...
Staphylococcus cohnii ssp. and S. urealyticus are a coagulase-negative staphylococci considered for long time as unable to cause infections. This situation changed recently pathogenic strains of these bacteria were isolated from hospital environments, patients medical staff. Most the resistant many antibiotics. The present work describes isolation characterization several synergistic peptide hemolysins produced by acting virulence factors responsible hemolytic cytotoxic activities. Amino...
A total of 104 coagulase negative staphylococci, belonging to S. capitis, hominis, haemolyticus and warneri, originating from the collection Department Pharmaceutical Microbiology (ZMF), Medical University Lodz, Poland, were tested for their synergistic hemolytic activity. 83% strains produced δ-hemolysin, however, percentage positive haemolyticus, capitis hominis was different - 98%, 78%, 75% 68%, respectively. Highly pure hemolysins obtained culture supernatants by protein precipitation...
Bacillus Calmette-Guérin (BCG) and pertussis vaccines have been found to be insufficient their further improvement is required. In order develop improved vaccines, a better understanding of the main pathways involved in host's protective immunity pathogens crucial. We address question as whether balance between pro- anti-inflammatory cytokine production might affect host responses BCG diphtheria-tetanus toxoids-whole cell (DTwP) vaccines. The study population consisted 118 healthy people,...