A5056202408- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Inflammatory mediators and NSAID effects
- Hepatitis C virus research
- Advancements in Transdermal Drug Delivery
- Peptidase Inhibition and Analysis
- Carbohydrate Chemistry and Synthesis
- Liver Disease Diagnosis and Treatment
- Neuropeptides and Animal Physiology
- Proteoglycans and glycosaminoglycans research
- Hepatitis B Virus Studies
Modern University for Information and Technology
2021-2024
Nahda University
2017
Loratadine (LTD) is an antihistaminic drug that suffers limited solubility, poor oral bioavailability (owing to extensive first-pass metabolism), and highly variable absorption. This study was undertaken develop statistically optimize transfersomal gel for transbuccal delivery of LTD. Transfersomes bearing LTD were prepared by conventional thin film hydration method optimized using sequential Quality-by-Design approach involved Placket–Burman design screening followed constrained...
Celecoxib (CLX), a selective inhibitor for cyclooxygenase 2 (COX-2), has manifested potential activity against diverse types of cancer. However, low bioavailability and cardiovascular side effects remain the major challenges that limit its exploitation. In this work, we developed ultra-elastic nanovesicles (UENVs) with pH-triggered surface charge reversal traits could efficiently deliver CLX to colorectal segments snowballed tumor targeting. CLX-UENVs were fabricated via thin-film hydration...
Introduction: Hepatitis C virus (HCV) is a significant public health concern that threatens millions of individuals worldwide. Daclatasvir (DAC) promising direct-acting antiviral approved for treating HCV infection around the world. The goal this study was to encapsulate DAC into novel polyethylene glycol (PEG) decorated bilosomes (PEG-BILS) achieve enhanced drug delivery liver. Methods: DAC-loaded BILS were primed by thin film hydrating technique. impact various formulation variables on...
Itraconazole (ITZ) is an antiangiogenic agent recognized as a potent suppressor of endothelial cell growth that suppresses angiogenesis. Nevertheless, its exploitation significantly restricted by low bioavailability and systematic side effects. The objective this study was to utilize glycerosomes (GLY), glycerol-developed vesicles, innovative nanovesicles for successful ITZ pulmonary drug delivery.