A5043708583- Occupational Health and Safety Research
- Human-Automation Interaction and Safety
- Immune Cell Function and Interaction
- Risk and Safety Analysis
- Research on Leishmaniasis Studies
- Synthesis and Biological Evaluation
- Trypanosoma species research and implications
- T-cell and B-cell Immunology
- Wound Healing and Treatments
- Immunotherapy and Immune Responses
- Microbial infections and disease research
- PI3K/AKT/mTOR signaling in cancer
- Surgical Sutures and Adhesives
- Antibiotics Pharmacokinetics and Efficacy
- Functional Brain Connectivity Studies
- Suicide and Self-Harm Studies
- Mental Health Research Topics
- Aquaculture disease management and microbiota
- Child and Adolescent Psychosocial and Emotional Development
- Corneal Surgery and Treatments
- Synthesis and Characterization of Heterocyclic Compounds
- 3D Printing in Biomedical Research
- Chronic Lymphocytic Leukemia Research
- Bacterial Infections and Vaccines
- Hydrogels: synthesis, properties, applications
Victoria University of Wellington
2020-2024
NHS Greater Glasgow and Clyde
2024
The University of Melbourne
2023
Texas Tech University
2017-2021
Texas Department of Family and Protective Services
2018-2021
Cancer Society of New Zealand
2011-2020
University of Auckland
2011-2020
John Wiley & Sons (United Kingdom)
2018
Hudson Institute
2018
Utah Valley University
2014
Protective immune responses against respiratory pathogens, such as severe acute syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are initiated by the mucosal system. However, most licensed vaccines administered parenterally largely ineffective at inducing immunity. The development of safe effective has been hampered lack a suitable adjuvant. In this study we explore class adjuvant that harnesses mucosal-associated invariant T (MAIT) cells. We show evidence intranasal immunization...
Percutaneous medical devices remain susceptible to infection and failure. We hypothesize that healing of the skin into percutaneous device will provide a seal, preventing bacterial attachment, biofilm formation, subsequent Porous poly(2-hydroxyethyl methacrylate) [poly(HEMA)] with sphere-templated pores (40 microm) interconnecting throats (16 were implanted in normal C57BL/6 mice for 7, 14, 28 days. Poly(HEMA) was either untreated, keeping surface nonadhesive cells proteins, or modified...
A network analysis approach to psychopathology regards symptoms as mutually interacting components of a multifaceted system (Borsboom & Cramer, 2013). Although several studies using this have examined comorbidity between disorders cross-sectional samples, direct application the intraindividual dynamic relations in complex, comorbid case has not been reported. The current article describes an (IDNA) understanding individual (over time) lead-lag interrelations symptoms. Multivariate time...
Within a backup program for the clinical investigational agent pretomanid (PA-824), scaffold hopping from delamanid inspired discovery of novel class potent antitubercular agents that unexpectedly possessed notable utility against kinetoplastid disease visceral leishmaniasis (VL). Following identification analogue DNDI-VL-2098 as VL preclinical candidate, this structurally related 7-substituted 2-nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazine was further explored, seeking efficacious compounds...
There are currently no pharmacological therapies to address the intellectual disability associated with Down syndrome. Excitatory/inhibitory imbalance has been hypothesized contribute impairments in cognitive functioning Negative modulation of GABAA-α5 receptor is proposed as a mechanism attenuate GABAergic function and restore excitatory/inhibitory balance.Basmisanil, selective negative allosteric modulator, was evaluated at 120 mg or 240 BID (80 160 for 12-13 years) 6-month, randomized,...
To establish a community database for children with autism spectrum disorder (ASD) to determine prevalence and identify subgroups based on key intellectual, clinical family parameters.Data were collected previously diagnosed an ASD in the Barwon region using parental interview review of child's paediatric psychological records. Preschool diagnoses typically made by specialist psychologists school-age multidisciplinary team.One hundred seventy-seven identified as having (82% response rate)....
Discovery of the potent antileishmanial effects antitubercular 6-nitro-2,3-dihydroimidazo[2,1- b][1,3]oxazoles and 7-substituted 2-nitro-5,6-dihydroimidazo[2,1- b][1,3]oxazines stimulated examination further scaffolds (e.g., 2-nitro-5,6,7,8-tetrahydroimidazo[2,1- b][1,3]oxazepines), but results for these seemed less attractive. Following screening a 900-compound pretomanid analogue library, several hits with more suitable potency, solubility, microsomal stability were identified, superior...
The interpersonal theory of suicide posits that thwarted belongingness (TB) and perceived burdensomeness (PB) increase ideation; however, studies have found mixed results regarding this hypothesis among psychiatric inpatients. This study aimed to (a) demonstrate how assessing TB PB using the Interpersonal Needs Questionnaire (INQ) can provide clinically useful information (b) investigate statistical methodology may impact clinical application INQ. Participants were 139 (Sample 1) 104 2) In...
Eliciting an antihapten antibody response to vaccination typically requires the use of constructs where multiple copies hapten are covalently attached a larger carrier molecule. The is required elicit T cell help via presentation peptide epitopes on major histocompatibility complex (MHC) class II molecules; as such, attachment full-sized proteins, alone or in complex, generally used account for significant MHC diversity humans. While such carrier-based vaccines have proven extremely...
The interaction between divalent cations and quinolones the mechanism by which former antagonizes antimicrobial activities of latter were investigated. In presence either magnesium or calcium chloride, MICs 18 for Gram-positive Gram-negative bacteria increased. Accumulation inhibition DNA synthesis decreased in chloride while, EDTA, there was no increase concentration accumulated quinolone any agents tested. Only with nalidixic acid enhancement synthesis. Chelation selected demonstrated a...
Abstract Three‐dimensional (3‐D) porous hydrogels were fabricated by polymerizing 2‐hydroxyethyl methacrylate around templates of random close‐packed poly(methyl methacrylate) microspheres with nominal diameter 5 or 15 μm. The leached out to create networks interconnected spherical pores. Applications for sphere‐templated biomaterials include scaffolds tissue engineering and spatial control wound healing. This study describes an approach characterizing pore structure predicting permeability...
Mucosal-associated invariant T (MAIT) cells are antibacterial effector that react to pyrimidines derived from bacterial riboflavin synthesis presented by the monomorphic molecule MR1. A major challenge in MAIT cell research is commonly used agonist precursor, 5-amino-6-d-ribitylaminouracil (5-A-RU), labile autoxidation, resulting a loss of biological activity. Here, we characterize two independent autoxidation processes LCMS. To overcome marked instability, report 5-A-RU prodrug generated...
ABSTRACT Percutaneous devices play an essential role in medicine; however, they are often associated with a significant risk of infection. One approach to circumvent infection would be heal the wound around by promoting skin cell attachment. We used two vitro assay models evaluate cutaneous response poly(2‐hydoxyethyl methacrylate) (poly(HEMA)). was use adhesion test effects surface modification poly(HEMA), and second organ culture system newborn foreskin biopsies implanted porous poly(HEMA)...
Abstract Percutaneous medical devices are integral in the management and treatment of disease. The space created between skin device becomes a haven for bacterial invasion biofilm formation results infection. We hypothesize that sealing this via integration into will create barrier against invasion. purpose study was to develop an animal model which interaction biomaterials can be evaluated. Porous poly(2‐hydroxyethyl methacrylate) [poly(HEMA)] rods were implanted 7 days dorsal C57 BL/6...
Metastasis is the principal cause of breast cancer mortality. Vaccines targeting antigens have yet to demonstrate clinical efficacy, and there remains an unmet need for safe effective treatment reduce risk metastasis, particularly people with triple-negative (TNBC). Certain glycolipids can act as vaccine adjuvants by specifically stimulating natural killer T (NKT) cells provide a universal form T-cell help.We designed made series conjugate vaccines comprising prodrug NKT cell-activating...
Abstract Human factors certification criteria are being developed for large civil aircraft with the objective of reducing incidence design-induced error on flight deck. Many formal identification techniques currently exist which have been in non-aviation contexts but none validated use to this end. This paper describes a new human technique (HET – template) designed specifically as diagnostic tool HET is benchmarked against three existing (SHERPA systematic reduction and prediction approach;...
A 900 compound nitroimidazole-based library derived from our pretomanid backup program with TB Alliance was screened for utility against human African trypanosomiasis (HAT) by the Drugs Neglected Diseases initiative. Potent hits included 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides, which surprisingly displayed good metabolic stability and excellent cell permeability. Following comprehensive mouse pharmacokinetic assessments on four determination of most active chiral form, a...
Mucosal-associated invariant T (MAIT) cells are unconventional which recognize microbial metabolites presented by the major histocompatibility complex class I-related molecule MR1. Although MAIT have been shown to reside in human and murine skin, their contribution atopic dermatitis (AD), an inflammatory skin disease associated with barrier dysfunction translocation, has not yet determined.Genetic deletion of MR1 topical treatment inhibitory ligands, result absence functional inhibition...