- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Sensors
- Electrochemical sensors and biosensors
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacological Effects and Assays
- Chemistry and Chemical Engineering
- Analytical Chemistry and Chromatography
- Drug Solubulity and Delivery Systems
- Electrochemical Analysis and Applications
University of Aleppo
2020-2024
This study presents a sustainable electrochemical investigation of pramipexole (PRA) in pharmaceuticals and human plasma, using cyclic differential pulse voltammetry. Key parameters, including potential range, buffer pH, accumulation period, scan rate were optimized, establishing efficient voltammetric methods for PRA analysis. The analytical range was 0.60–12.00 μ g ml −1 , with detection limit 0.14 correlation coefficient 0.9998. Recovery rates ranged from 98.60 ± 0.26% to 101.33 0.38%,...
The Current study describes the construction of three carbon paste electrodes for quantitative measurement third-generation antihistamines fexofenadine (FEX), Desloratadine (DES), and Levocetirizine (LEV). different assembly steps sensor are described. proposed potentiometric method Presents a green, fast, simple, sensitive procedure determination these drugs in their pure pharmaceutical forms. was achieved using constructed electrodes. presented analytical obeyed linearity concentration...
Abstract This paper introduces the first electrochemical approach for determination of Fexofenadine hydrochloride and Montelukast sodium as a combined form by constructing three new graphite electrodes coated with polymeric membrane. The electrode was constructed using ammonium molybdate reagent an ion pair fexofenadine cation drug, second cobalt nitrate montelukast anion third prepared incorporating two previously mentioned pairs in same sensor, which makes this sensor sensitive to each...
Coated wire electrodes (CWEs) are considered the most effective and selective type of ion- because electroactive materials which used in surface modification.This study aims to construct first potentiometric method for analysis levocetirizine (LVZ) its combination form with montelukast (MON) drug.A novel sensor consists a silver coated zinc oxide (ZnO) nanorod modified polymeric membrane (combining β-cyclodextrin tetraphenyl borate, plasticized di-butyl phthalate) was constructed...
The construction and performance characteristics of Prasugrel hydrochloride (PRS) selective electrodes were developed. Electrodes based on the incorporation PRS with pairing agents, Ammonium Molybdate (MOL) Nessler reagent (NES). displayed a Nernstian response mean calibration graphs slopes 59.21, 27.57 mv.decade-1 for two respectively, over linear concentration range 10-2 –10-5 mol L-1 drug, detection limits 0.063, 0.090 µM quantification 0.27, 0.192 electrode 1 2 respectively. safe pH...
In this study, we present a new, green electrochemical method for potentiometric estimation of desloratadine and montelukast sodium in their pure binary dosage form. For that, three pencil graphite sensors were fabricated; the first one was prepared to analyse drug (DES) by coating bar with membrane, which comprises ion pair ammonium reineckate reagent (RNK), polymer poly vinyl chloride (PVC), plasticizers dibutyl phthalate (DBP). The second one, used (MON), constructed using cadmium (Cd.)...
Newly developed ion selective electrode has been for determination of Clopidogrelbisulphate(CLP) in pure form and pharmaceutical preparations. The was constructed from Clopidogrel with pairing agent Nesslerreagentin presence di-n-butyl phthalate (DBP) as the plasticizing solvent mediator. displayed a Nernstian response mean calibration graphs slopeof 28.37 mv.decade−1, over linear concentration range 10−2-10−5M drug, detection limits 0.063 μMand quantification 0.191 μM. effective at pH...
Abstract This paper introduces a new electrochemical approach for the concomitant determination of fexofenadine hydrochloride and montelukast sodium by constructing three graphite electrodes coated with polymeric membrane. The first electrode was constructed using ammonium molybdate reagent as an ion pair cation drug, second cobalt nitrate anion third prepared incorporating two previously mention pairs in same sensor, which make this sensor sensitive to each drug. coating material film...