The cutting-edge combination of aspirin (ASA) and sildenafil citrate (SIC) has been presented as a suggested dosage form for the treatment thin endometrium erectile dysfunction, particularly in patients with cardiovascular diseases. However, ASA is highly sensitive to degradation into its major deterioration product, known salicylic acid (SA). Consequently, it eminently essential evolve approaches synchronous quantification SIC presence SA.The main objective this work develop three SA their...

Six spectrophotometric methods were developed to determine a new single-dose otic solution known as “Otovel®,” which consists of two components: the major one is ciprofloxacin (CIP) and minor fluocinolone acetonide (FLU). The ratio (FLU) in Otovel® 12 : 1, considered challengeable for UV determination. Thus, spectrum addition sample enrichment technique was required analysis low concentration. All these capable resolving spectra each component D 0 belonging fingerprint resolution technique....

Dietary folate status as well polymorphisms in one-carbon metabolism genes may affect the risk of breast cancer through aberrant DNA methylation and altered nucleotide synthesis repair. A large number studies investigated role methylenetetrahydrofolate reductase (MTHFR) methionine synthase (MTRR) with inconsistent results. Association between multiple was not studied before an Arab population. The purpose present study is to test hypothesis that are associated susceptibility Syrian women...

pure component contribution algorithm (PCCA) is a green analytical method was developed for extracting the of each from mixture where components this are completely overlapped. It based on elimination signal interfering using mean centering as processing tool; finally extracted form complex signals and that worked finger-print resolution component. has been successfully applied to UV data binary ciprofloxacin (CIP) metronidazole (MET) overlapped able determine in form. The results were...

Abstract Background The pharmaceutical industry and the National Regulatory Authorities are now focusing on quantification of multi-component drugs for quality control testing. Main body Recently, utilization ultraviolet spectrophotometric methods has become vital analytical studies routine analysis different fixed-dose combination products either in presence a minor component their or not. This article reviewed several published to those that have been applied quantify some combinations...

The Current study describes the construction of three carbon paste electrodes for quantitative measurement third-generation antihistamines fexofenadine (FEX), Desloratadine (DES), and Levocetirizine (LEV). different assembly steps sensor are described. proposed potentiometric method Presents a green, fast, simple, sensitive procedure determination these drugs in their pure pharmaceutical forms. was achieved using constructed electrodes. presented analytical obeyed linearity concentration...

Abstract Background Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that has analgesic, anti-inflammatory, and antipyretic properties. Caffeine one of the most common adjuvant analgesic drugs which combined with ibuprofen in commercially available formulations. Combining analgesics offers possibility increasing effectiveness without dose therefore risk. Prescribing caffeine together clinical practice. This first work reporting new validated gas chromatographic method for...

Four spectrophotometric approaches were performed to determine a binary combination of Phenazone and Benzocaine in pure powder form pharmaceutical formations. This investigation submits the application four techniques contingent on presence extended area spectra one compound mixture, these methods include Absorptivity Centering (a-centering), Absorbance Subtraction (AS), Amplitude Modulation (AM) Concentration Value (CV). The linearity range for above-mentioned was found be 3.0–15.0 μg/mL...

Abstract Background Perindopril erbumine is an antihypertensive, which belongs to the category of angiotensin-converting enzyme inhibitors (ACE inhibitors) that inhibit conversion angiotensin I II. Methods A new, selective, and sensitive spectrofluorimetric method was developed for determination perindopril based on reaction with dansyl chloride in alkaline medium give a highly fluorescent derivative measured at 496 nm after excitation 340 dichloromethane. The conditions were studied...

To investigate the ability of incorporating more than one ion pair in same selective electrode's membrane, and so constructing an electrode sensitive to either Ciprofloxacin (CFX) or Metronidazole (MZL) according standard filling solution electrode, subsequently determine two drugs CFX MZL Simultaneously their combined solutions, 3 PVC membrane drug sensors were constructed for analysis intended. The electro active materials CFX-Phosphotungstic Acid (CFX-PTA), MZL-Phosphotungstic (MZL-PTA) a...

Abstract This paper introduces the first electrochemical approach for determination of Fexofenadine hydrochloride and Montelukast sodium as a combined form by constructing three new graphite electrodes coated with polymeric membrane. The electrode was constructed using ammonium molybdate reagent an ion pair fexofenadine cation drug, second cobalt nitrate montelukast anion third prepared incorporating two previously mentioned pairs in same sensor, which makes this sensor sensitive to each...

Abstract In this manuscript, the effectiveness of multivariate and univariate tools in conjunction with spectrophotometric techniques was evaluated for concurrent analysis ciprofloxacin (CI) ornidazole (OR) prepared mixtures, tablets, human serum. The artificial neural network chosen as Technique. Bayesian regularization (trainbr) Levenberg–Marquardt algorithms (trainlm), were constructed trained using feed-forward back-propagation learning. optimal logarithm determined based on mean...

In the past decade, significant advancements have been made in mathematical spectral approaches for estimating binary and ternary drug combinations raw materials dosage forms. These established on manipulations of mixture analytes, without need separation techniques. The idea using fluorescence spectroscopy was resolving analytical issues reach to biological concentrations thus, Ratio subtraction (RD) ratio coupled with constant multiplication (RS-CM) proposed evaluate content uniformity...

Objective: To develop and validate simple, sensitive, precise free of organic solvents method for the determination sildenafil (SIL) vardenafil (VAR) in bulk pharmaceutical formulation.Methods: The is based on reaction studied drugs with a mixture potassium iodide iodate an aqueous medium at (25±2 °C) to form yellow coloured triiodide ions (I3-) within 45 min. followed spectrophotometrically by measuring absorbance 288, 351 nm 285, respectively.Results: effects analytical parameters reported...

Ciprofloxacin is a second generic and an antibiotic drug. It very popular fluoroquinolone that can treat number of bacterial infections. The quinolones are family or group has activity against both-negative positive-gram bacteria, when compared to Ciprofloxacin. first aim this review provide comprehensive update analytical methods for determining the its combinations, binary triple mixture use endodontic treatment primary teeth using combination antibacterial drugs. other evaluate clinical...