A5006686384- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Surgical Treatments
- Lung Cancer Research Studies
- Cardiac tumors and thrombi
- Brain Metastases and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Helicobacter pylori-related gastroenterology studies
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Vascular Tumors and Angiosarcomas
- Clostridium difficile and Clostridium perfringens research
- Microscopic Colitis
- Cancer Immunotherapy and Biomarkers
- Global Cancer Incidence and Screening
- Economic and Financial Impacts of Cancer
- Medical Imaging Techniques and Applications
- Sarcoma Diagnosis and Treatment
Helios Klinikum Emil von Behring
2019-2023
University Hospital Heidelberg
2022
Heidelberg University
2022
University of Bologna
2022
German Center for Lung Research
2022
Universitätsklinikum Würzburg
2022
Comprehensive Cancer Center Mainfranken
2022
University of Würzburg
2022
Evangelische Lungenklinik Berlin
2021
Current antibiotic therapies for Clostridium difficile-associated diarrhea have limitations, including progression to severe disease, recurrent C. diarrhea, and selection nosocomial pathogens. Tolevamer, a soluble, high-molecular weight, anionic polymer that binds difficile toxins A B is unique nonantibiotic treatment option.In this 3-arm, multicenter, randomized, double-blind, active-controlled, parallel-design phase II study, patients with mild moderately were randomized receive 3 g of...
Despite a long-known association between annual hospital volume and outcome, little progress has been made in shifting high-risk surgery to safer hospitals. This study investigates whether the risk-standardized mortality rate (RSMR) could serve as stronger proxy for surgical quality than volume.We included all patients who underwent complex oncologic surgeries Germany 2010 2018 any of five major cancer types, splitting data into training (2010-2015) validation sets (2016-2018). For each...
In the context of new targeted therapies and immunotherapy as well screening modalities for lung cancer patients, detailed mortality trends in Europe Northern America are unknown.Time-trend analysis using vital registration data from WHO Mortality Database (years 2000/2017). To assess improvements mortality, we performed a population-averaged Poisson autoregressive analysis. The average annual percent change (AAPC) was used summary measure overall country-specific mortality. Second, studied...
In patients with non-small cell lung cancer (NSCLC) the pathologic lymph node status N1 is a heterogeneous entity, and different forms of involvement may represent prognoses. For methodological reasons, 8th edition TNM staging system for NSCLC makes no official changes to N descriptor. However, there evidence that subforms disease are associated prognoses, it now recommended clinicians record number affected nodes nodal stations further analyses. this investigation we sought determine...
In patients with non-small cell lung cancer (NSCLC) the pathologic lymph node status N2 is a heterogeneous entity, different degrees of involvement representing prognoses. It speculated whether extra capsular nodal extension may help to define subgroup implications on long-term survival.We retrospectively identified 118 (65 men, 53 women), who were treated between 2013 and 2018 found have involvement. all resection systematic mediastinal hilar dissection was performed curative intent....
Abstract Objectives The purpose of this study was to investigate the value PET/CT in preoperative staging non-small cell lung cancer predicting long-term survival and diagnostic performance, validated by histopathology following surgical resection. Methods Between 02/2009 08/2011, 255 patients with were included single-center prospective study. All underwent 18F FDG-PET/CT for pre-operative staging, 243 complete resection possible. Regarding lymph node involvement extrathoracic metastases,...
The current pT3N0 category represents a heterogeneous subgroup involving tumor size, separate nodes in one lobe, and locoregional growth pattern. We aim to validate outcomes according the eighth edition of TNM staging classification. A total 281 patients who had undergone curative lung cancer surgery staged with TNM-7 two German centers were retrospectively analyzed. subtypes size >7 cm multiple nodules grouped as T3a, parietal pleura invasion mixed T3b. stratified survival by subtype...
A 68-year-old patient presented with persistent hemoptysis and weight loss. CT scan showing diffuse bilateral ground-glass opacities nodules was followed by bronchoscopy. While alveolar hemorrhage (DAH) could be seen, specimens obtained during bronchoscopy did not provide conclusive histological findings. The decision made to conduct video-assisted wedge resection, after which examinations revealed the diagnosis of bifocal nodular manifestation an epithelioid angiosarcoma in lung. Being a...
Lymph node status is of utmost importance in determining prognosis and planning therapy for patients with non-small cell lung cancer (NSCLC). Due to methodological difficulties no changes were made the nodal (N) descriptors 8th edition NSCLC staging. It recommended, however, that clinicians record more detailed information about metastases, so prognostically discriminative subcategories may be established. Here we analyzed surgical N1 lymph metastases determine whether number station had an...
Abstract Background In patients with non-small cell lung cancer (NSCLC), the pathologic union for international control (UICC) stage IIIA is a heterogeneous entity, different forms of N2-lymph node involvement representing prognoses. Although multimodality treatment approach, including surgery, systemic therapy, and/or radiotherapy, almost always recommended, in this retrospective observational study, we sought to determine whether long-term survival might be possible selected who are...
Zusammenfassung Das Stadium der Oligometastasierung ist definiert als eine klinisch und radiologisch an Anzahl Tumorvolumen limitierte im Verlauf stabile Metastasierung. Ist das Metastasierungsausmaß auf 1 oder 2 Organsysteme die Metastasen maximal 5 begrenzt, so können unterschiedliche lokal ablative Verfahren, wie chirurgische Resektion stereotaktische Strahlentherapie, ihre Berechtigung haben. Die biologischen Grundlagen eines intermediären Tumorstadiums sind heute noch weitestgehend...
This prospective study assessed the role of F-18-FDG-PET/CT in clinical staging for patients with colorectal cancer planned pulmonary metastasectomy by thoracotomy or video-assisted surgery.In addition to conventional imaging, we performed 86 studies 76 potentially resectable metastatic lung metastases. We then investigated effect that PET/CT had on further management. Based results from 47 thoracotomies performed, compared number metastases discovered after histologic examination predicted...