A5018253905- RNA Research and Splicing
- Microtubule and mitosis dynamics
- interferon and immune responses
- Insect and Arachnid Ecology and Behavior
- Insect Utilization and Effects
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- Virus-based gene therapy research
- RNA regulation and disease
- Neurobiology and Insect Physiology Research
- Axon Guidance and Neuronal Signaling
- RNA and protein synthesis mechanisms
- Herpesvirus Infections and Treatments
- Parvovirus B19 Infection Studies
- Photosynthetic Processes and Mechanisms
- CRISPR and Genetic Engineering
- Protist diversity and phylogeny
- Cell Image Analysis Techniques
- Genetic and Kidney Cyst Diseases
- 14-3-3 protein interactions
- Viral Infectious Diseases and Gene Expression in Insects
- RNA modifications and cancer
- MicroRNA in disease regulation
National Institute of Neurological Disorders and Stroke
2022-2023
Rockefeller University
2017-2022
Howard Hughes Medical Institute
2021-2022
National Institutes of Health
2022
Columbia University
2011
Plasma microRNAs (miRNAs) are modulated during disease and emerging biomarkers; they have not been characterized in HIV infection. Using our macaque/simian immunodeficiency virus (SIV) model of HIV, we sought to identify a plasma miRNA profile acute lentiviral infection, evaluate its relationship with known cellular viral determinants lentivirus-associated central nervous system (CNS) disease, explore the potential miRNAs predict CNS disease.Plasma samples were obtained before inoculation 10...
To better understand how animals make ethologically relevant decisions, we studied egg-laying substrate choice in Drosophila. We found that flies dynamically increase or decrease their rates while exploring substrates so as to target eggs the best, recently visited option. Visiting best option typically yielded inhibition of egg laying on other for many minutes. Our data support a model which compare current substrate's value with an internally constructed expectation available options...
The journey from plasma membrane to nuclear pore is a critical step in the lifecycle of DNA viruses, many which must successfully deposit their genomes into nucleus for replication. Viral capsids navigate this vast distance through coordinated hijacking number cellular host factors, remain unknown. We performed gene-trap screen haploid cells identify factors adenovirus (AdV), virus that can cause severe respiratory illness immune-compromised individuals. This work identified Mindbomb 1...
Neurons rely on mRNA transport and local translation to facilitate rapid protein synthesis in processes far from the cell body. These allow precise spatial temporal control of are mediated by RNA binding proteins (RBPs), including those known be associated with neurodegenerative diseases. Here, we use proteomics, transcriptomics, microscopy investigate impact RBP knockdown iPSC-derived neurons. We find thousands transcripts enriched neurites that many these locally translated, possibly due...
Summary When presented with two egg-laying substrates, Drosophila lay most of their eggs on the option higher relative value. How do flies make this relative-value decision? Might strategy they use allow them to choose best even when experience substrates a more complex spatiotemporal profile than in canonical two-choice paradigms? We measured behavior diverse substrate environments. In all cases, we found that dynamically increase or decrease rates as explore for deposition site so target...