A5051954076- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Drug-Induced Hepatotoxicity and Protection
- Acupuncture Treatment Research Studies
- Traditional Chinese Medicine Analysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Chemotherapy-induced organ toxicity mitigation
- CRISPR and Genetic Engineering
- Andrographolide Research and Applications
- Medicinal Plant Pharmacodynamics Research
- Pluripotent Stem Cells Research
- Cancer-related molecular mechanisms research
- Lipid metabolism and disorders
- RNA modifications and cancer
- Polysaccharides and Plant Cell Walls
- Cancer, Hypoxia, and Metabolism
- Mycobacterium research and diagnosis
- Neurological Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Complementary and Alternative Medicine Studies
- Pancreatitis Pathology and Treatment
Nanjing University of Chinese Medicine
2018-2024
Kleijnen Systematic Reviews (United Kingdom)
2021
Weatherford College
2021
Ollscoil na Gaillimhe – University of Galway
2019
Magnesium isoglycyrrhizinate (MgIG), which has been widely employed to treat chronic hepatitis, is synthesized from 18-β glycyrrhizic acid, a main component of traditional Chinese medicine Glycyrrhiza uralensis Fisch. Although the protective effects MgIG on methotrexate (MTX)-induced liver toxicity have well-documented, underlying mechanism remains elusive. MTX was initially used pediatric acute leukemia, and applied psoriasis therapy. However, its clinical applications are limited due...
Background The gut–liver axis plays a crucial role in various liver diseases. Therefore, targeting this crosstalk may provide new treatment strategy for However, the exact mechanism underlying and its impact on drug-induced injury (DILI) requires clarification. Aim This study aimed to investigate potential therapeutic effect of MgIG MTX-induced injury, which is associated with gut microbiota. Methods An model was generated after 20-mg/kg/3d MTX application 30 days. Meanwhile, group treated...
Background: Ischemic stroke (IS) is one of the leading causes death and disability worldwide. The narrow therapeutic window (within 4.5 h) severe hemorrhagic potential limits efficacy recombinant tissue type plasminogen activator (rt-PA) intravenous thrombolysis for patients. Xingnao Kaiqiao (XNKQ) acupuncture an integral part traditional Chinese medicine, specifically designed to address acute ischemic by targeting key acupoints such as Shuigou (GV26) Neiguan (PC6). In this study, we...
Background: The interactions between platelets and tumor cells are well-known to play important roles in the progression of malignant tumors. Danshensu, a main water-soluble component Salvia miltiorrhiza, can resist platelet aggregation exert significant anti-tumor effects on various types However, whether Danshensu could inhibit tumors by suppressing activities had not been reported. Methods: activity epithelial-mesenchymal transformation (EMT)-like invasive phenotype SW620 colon cancer...
Oxaliplatin is widely used in cancer chemotherapy with adverse effects such as liver toxicity. Magnesium isoglycyrrhizinate (MgIG) has hepatoprotective effects, but the underlying mechanism remains elusive. The study's aim was to investigate of MgIG against oxaliplatin-induced injury.A xenografted colorectal mouse model established MC38 cells. Mice were given oxaliplatin (6 mg/kg/week) for 5 weeks mimic injury vivo. LX-2 human hepatic stellate cell s(HSCs) employed vitro studies. Serological...
NRXN1 copy number variation is a rare genetic factor commonly shared among autism spectrum disorder (ASD), schizophrenia, intellectual disability, epilepsy and developmental delay. Human induced pluripotent stem cells (iPSCs) are essential for disease modeling drug discovery, but familial cases particularly rare. We report here the derivation of iPSC lines from two controls three ASD patients carrying NRXN1α+/−, using non-integrating Sendai viral kit. The genotype karyotype resulting iPSCs...
Corona virus disease 2019 (COVID-19) is spreading fast and it brings great pressure to the social economy. Many reports revealed that ginseng can develop immunity for respiratory disease, but there no evidence prove its effects on COVID-19. This protocol of systematic review meta-analysis will clarify safety effectiveness adjuvant therapy COVID-19 patients.Different databases (Web Science, Cochrane Library, PubMed, Chinese Biomedical Literature Database, National Knowledge Infrastructure,...
Magnesium isoglycyrrhizinate (MgIG) is a novel compound of α-isomer synthesized from 18 β-glycyrrhizic acid by isomerization and salification. MgIG commonly used drug to protect the liver in clinical practice, mainly distributed tissues. Preclinical studies have proven its hepatoprotective effects on FOLFOX -induced injury. However, mechanism underlying protection induced hepatotoxicity has not been reported. And we found good protective effect against damage xenografted tumor-bearing...