A5027541051- Multiple Myeloma Research and Treatments
- Pluripotent Stem Cells Research
- Acute Myeloid Leukemia Research
- Protein Degradation and Inhibitors
- CRISPR and Genetic Engineering
- Neuroscience and Neural Engineering
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Autism Spectrum Disorder Research
- 3D Printing in Biomedical Research
- Cardiac electrophysiology and arrhythmias
- Hematopoietic Stem Cell Transplantation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Mesenchymal stem cell research
- Diabetic Foot Ulcer Assessment and Management
- Immunotherapy and Immune Responses
- Angiogenesis and VEGF in Cancer
- Glycosylation and Glycoproteins Research
- Peptidase Inhibition and Analysis
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- Biomedical Ethics and Regulation
Ollscoil na Gaillimhe – University of Galway
2009-2024
University Hospital Galway
2014-2024
University of Warsaw
2023
Cancer Trials Ireland
2019-2022
University of London
2022
Saolta University Health Care Group
2021-2022
King Saud University
2022
King Faisal Specialist Hospital & Research Centre
2022
Riyadh Armed Forces Hospital
2022
King's College Hospital
2022
Cellular reprogramming is a stressful process, which requires cells to engulf somatic features and produce maintain stemness machineries. Autophagy process degrade unwanted proteins required for the derivation of induced pluripotent stem (iPSCs). However, role autophagy during iPSC maintenance remains undefined.Human iPSCs were investigated by microscopy, immunofluorescence, immunoblotting detect machinery. Cells treated with rapamycin activate bafilomycin block maintenance. High...
Platelet-rich plasma (PRP) is a concentrate of autologous blood growth factors which has been shown to provide some symptomatic relief in early osteoarthritis (OA) the knee. The objective this study was test feasibility and efficacy potential platelet rich primary care.Feasibility assess safety intervention procedures secondary outcome measures. Consecutive patients presenting with knee OA were recruited care setting Ireland. All participants received three injections PRP 4 weeks apart....
Abstract Background Autism spectrum disorder (ASD) is a neurodevelopmental with high co-morbidity of epilepsy and associated hundreds rare risk factors. NRXN1 deletion among the commonest genetic factors shared by ASD, schizophrenia, intellectual disability, epilepsy, developmental delay. However, how deletions lead to different clinical symptoms unknown. Patient-derived cells are essential investigate functional consequences lesions human neurons in diseases. Methods Skin biopsies were...
Critical limb ischemia (CLI) is the most severe manifestation of peripheral vascular disease. Revascularization preferred therapy, but it not achievable in 25%-40% patients due to diffuse anatomic distribution disease or medical comorbidities. No-option CLI represents an unmet need. Mesenchymal stromal cells (MSCs) may provide salvage therapy through their angiogenic and tissue-trophic properties. This article reports a phase 1b clinical study examining safety feasibility intramuscular...
Natural killer (NK) cell genome editing promises to enhance the innate and alloreactive anti-tumor potential of NK adoptive transfer. DNA transposons are versatile non-viral gene vectors now being adapted primary cells, representing important tools for research clinical product development.We set out generate donor-derived, chimeric antigen receptor (CAR)-NK cells by combining TcBuster transposon system with Epstein-Barr virus-transformed lymphoblastoid feeder cell-mediated activation...
Abstract Background NRXN1 deletions are identified as one of major rare risk factors for autism spectrum disorder (ASD) and other neurodevelopmental disorders. ASD has 30% co-morbidity with epilepsy, the latter is associated excessive neuronal firing. encodes hundreds presynaptic neuro-adhesion proteins categorized NRXN1α/β/γ. Previous studies on cultured cells show that short NRXN1β primarily exerts excitation effect, whereas long NRXN1α which more commonly deleted in patients involves both...
Abstract Brain‐derived neurotrophic factor (BDNF) is a protein with potent influence on several aspects of neuronal and blood vessel functions. However, its prognostic potential functional role in multiple myeloma (MM) remain largely unknown. In this study, we investigated the BDNF risk chemotherapy‐induced peripheral neuropathy (CIPN) clinical outcome. Study group consisted 91 newly‐diagnosed MM patients treated bortezomib and/or thalidomide‐based chemotherapy. Detection serum was performed...
The anti-apoptotic proteins Bcl-XL and Bcl-2 are abundantly expressed in hematopoietic stem cells and/or progenitor cells. Furthermore, leukemic expressing these enriched minimal residual disease cell populations. This prompted us to test the BH3-mimetic compound ABT-737 for its ability eradicate putative demonstrated potent cytotoxic effects all patient samples tested. efficacy of against AML blasts primitive CD34(+)/CD38(-) population was equal independent sensitivity...
Abstract Daratumumab (DARA) has shown impressive activity in combination with other agents for the treatment of multiple myeloma (MM). We conducted a phase 1b study to assess safety and preliminary efficacy, as well potential mechanisms action, DARA (16 mg/kg) weekly schedule subcutaneous bortezomib (1.3-1.5 mg/m2), cyclophosphamide (150-300 dexamethasone (40 mg) (CyBorD DARA) initial induction before autologous stem cell transplantation (ASCT). Eligible patients were ≤70 years age untreated...
Worldwide diffused diseases such as osteoarthritis, atherosclerosis or chronic kidney disease are associated with a tissue calcification process which may involve unexpected local stem cell differentiation. Current pharmacological treatments for musculoskeletal conditions weakly effective, sometimes extremely expensive and often absent. The potential to develop new therapies is represented by the discovery of small molecules modulating resident progenitor differentiation prevent aberrant...
While most patients with chronic myeloid leukemia (CML) express either e13a2 or e14a2 BCR-ABL1 transcripts, a significant minority expresses variant of which e19a2 is the common. Although considered to have relatively favourable outcome, reported responses tyrosine kinase inhibitor (TKI) therapy are variable molecular monitoring in CML transcripts rarely reported. A case marked thrombocytosis described value emphasised during treatment interruptions, dose reductions, and changes. This serves...
In recent years mesenchymal stromal cells (MSCs) have received a great deal of interest for the treatment major diseases, but clinical translation and market authorization been slow. This has due in part to lack standardization cell manufacturing protocols, as well biologically meaningful characterization tools release assays. Cell production strategies date involved complex manual processing an open environment which is costly, inefficient poses risks contamination. The NANT 001 bioreactor...
Pregnancy induces physiological changes which affect biochemical and haematological parameters. As the significance of laboratory test results change throughout pregnancy, reference interval (RI) or key result interpretive guide should be specific to pregnancy. This study sought establish trimester-specific-RIs for routine tests in healthy white European women with singleton pregnancies comparison RIs non-pregnant adults.A retrospective analysis a prospective longitudinal single-centre...