A5028017651- Retinopathy of Prematurity Studies
- Cellular transport and secretion
- Retinal Development and Disorders
- Neuroscience and Neural Engineering
- Neonatal and fetal brain pathology
- Neuroscience and Neuropharmacology Research
- Neonatal Respiratory Health Research
- Receptor Mechanisms and Signaling
- Neurobiology and Insect Physiology Research
- Pluripotent Stem Cells Research
- Lipid Membrane Structure and Behavior
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Nutrition and Health in Aging
- Plant Molecular Biology Research
- Glaucoma and retinal disorders
- Health and Wellbeing Research
- Ocular Diseases and Behçet’s Syndrome
- Ophthalmology and Eye Disorders
- Zebrafish Biomedical Research Applications
- Photoreceptor and optogenetics research
- Retinal and Optic Conditions
- CRISPR and Genetic Engineering
Trinity College Dublin
2019-2022
Duke University
2016-2021
University of California, San Diego
2009-2015
A major goal of stem-cell research is to identify conditions that reliably regulate their differentiation into specific cell types. This particularly important for human stem cells if they are be used in vivo transplantation or as a platform drug development. Here we describe the establishment procedures direct embryonic and induced pluripotent forebrain neurons capable forming synaptic connections. In addition, HEK293T expressing Neuroligin (NLGN) 3 NLGN4, but not those containing...
Abstract Müller glia, the most abundant glia of vertebrate retina, have an elaborate morphology characterized by a vertical stalk that spans retina and branches in each retinal layer. play diverse, critical roles homeostasis, which are presumably enabled their complex anatomy. However, much remains unknown, particularly mouse, about anatomical arrangement cells arbors, how these features arise development. Here we use membrane‐targeted fluorescent proteins to reveal fine structure mouse...
Abstract Immature astrocytes and blood vessels enter the developing mammalian retina at optic nerve head migrate peripherally to colonize entire retinal fiber layer (RNFL). Retinal vascularization is arrested in retinopathy of prematurity (ROP), a major cause bilateral blindness children. Despite their importance normal development ROP, factors that control remain poorly understood. Because form reticular network appears provide substrate for migrating endothelial cells, they have long been...
Latrophilins (LPHNs) are a small family of neuronal adhesion-GPCRs originally discovered as receptors for the black widow spider toxin α-latrotoxin. Mutations in LPHN3 have recently been identified risk factors attention deficit hyperactivity disorder (ADHD) humans, but their physiological function has remained elusive. In this study, we tested two hypotheses regarding function: (1) regulates synaptic transmission by modulating probability release; and (2) controls synapse development...
Abstract Background Autism spectrum disorder (ASD) is a neurodevelopmental with high co-morbidity of epilepsy and associated hundreds rare risk factors. NRXN1 deletion among the commonest genetic factors shared by ASD, schizophrenia, intellectual disability, epilepsy, developmental delay. However, how deletions lead to different clinical symptoms unknown. Patient-derived cells are essential investigate functional consequences lesions human neurons in diseases. Methods Skin biopsies were...
Children with a history of prematurity often have poorly developed foveae but when during development foveal differences arise. We hypothesize that the course is altered from time preterm birth.Eyes 102 infants undergoing retinopathy screening examinations in STudy Eye imaging Premature infantS (BabySTEPS) (NCT02887157) were serially imaged between 30 and 42 weeks postmenstrual age (PMA) using handheld optical coherence tomography systems. Total retinal thickness, inner layer (IRL) outer...
Abstract Background NRXN1 deletions are identified as one of major rare risk factors for autism spectrum disorder (ASD) and other neurodevelopmental disorders. ASD has 30% co-morbidity with epilepsy, the latter is associated excessive neuronal firing. encodes hundreds presynaptic neuro-adhesion proteins categorized NRXN1α/β/γ. Previous studies on cultured cells show that short NRXN1β primarily exerts excitation effect, whereas long NRXN1α which more commonly deleted in patients involves both...
ABSTRACT Angiogenesis in the developing mammalian retina requires patterning cues from astrocytes. Developmental disorders of retinal vasculature, such as retinopathy prematurity (ROP), involve arrest or mispatterning angiogenesis. Whether these vascular pathologies astrocyte dysfunction remains untested. Here, we demonstrate that major risk factor for ROP – transient neonatal exposure to excess oxygen disrupts formation angiogenic template. Exposing newborn mice elevated (75%) suppressed...
To characterize changes in subfoveal choroidal thickness preterm infants from 30 to 60 weeks' postmenstrual age (PMA).
Müller glia, the most abundant glia of vertebrate retina, have an elaborate morphology characterized by a vertical stalk that spans retina and branches in each retinal layer. play diverse, critical roles homeostasis, which are presumably enabled their complex anatomy. However, much remains unknown, particularly mouse, about anatomical arrangement cells arbors, how these features arise development. Here we use membrane-targeted fluorescent proteins to reveal fine structure mouse arbors. We...
Abstract Angiogenesis in the developing mammalian retina requires patterning cues from astrocytes. Developmental disorders of retinal vasculature, such as retinopathy prematurity (ROP), involve arrest or mispatterning angiogenesis. Whether these vascular pathologies astrocyte dysfunction remains untested. Here we demonstrate that major risk factor for ROP – transient neonatal exposure to hyperoxia disrupts formation angiogenic template. Exposing mice (75% O 2 ) postnatal day (P)0-4...
Traumatic injury to the optic chiasm is rare and most frequently caused by high-velocity head trauma. It classically results in bitemporal hemianopsia often presents conjunction with multiple other traumatic injuries, such as skull fractures cerebrospinal fluid leaks. We present case of a 40-year-old woman pre-existing thyroid orbitopathy who struck her forehead after fall from standing height.This patient suffered immediate profound unilateral vision loss neuropathy possible nerve avulsion....
Abstract Background Sarcopenia, frailty, and malnutrition are known determinants of adverse health outcomes. Adults advanced age, with functional dependency, socioeconomic disadvantage, or a need for home care, expected to be at high risk these conditions yet likely underrepresented in research. We aimed examine the feasibility preliminary outcomes conducting home-based assessments this group. Methods Home-based were conducted among older adults (n= 31), receipt state-funded care....
Abstract Background Physical activity programmes have been shown to improve older adults’ functional capacity, independence and quality of life. Research around structured exercise has completed in different groups community-dwelling people, however few studies focused on the population receiving formal home care. In a feasibility study, we embedded physical within adults existing care services through ‘Care Move’ (CTM) programme. The aim this qualitative study is explore experiences CTM...