Multiple myeloma (MM) is the second most common hematologic malignancy in world and accounts for 15% of primary hemocytopathies, with an ever-increasing number new cases. It asymptomatic 30% instances; hence, determination highly sensitive specific markers necessary to make a proper diagnosis. In last 20 years, miRNAs, involved regulating expression genes responsible cell proliferation differentiation, including tumor cells, have been identified as potential diagnostic prognostic markers....

Abstract Brain‐derived neurotrophic factor (BDNF) is a protein with potent influence on several aspects of neuronal and blood vessel functions. However, its prognostic potential functional role in multiple myeloma (MM) remain largely unknown. In this study, we investigated the BDNF risk chemotherapy‐induced peripheral neuropathy (CIPN) clinical outcome. Study group consisted 91 newly‐diagnosed MM patients treated bortezomib and/or thalidomide‐based chemotherapy. Detection serum was performed...

Abstract Neutrophils to lymphocytes ratio (NLR) and platelets (PLR) are considered as laboratory markers of inflammation. They can be potentially useful in predicting the course multiple neoplasms including selected hematological cancers. The aim study was assess value NLR PLR effects therapy prognosis myeloma patients treated with thalidomide-based regimen. group consisted 100 first line CTD (cyclophosphamide, thalidomide, dexamethasone) chemotherapy. were calculated before treatment. High...

Introduction. Interest in the potential role of low-density granulocytes (LDGs) development autoimmune diseases has been renewed recently. Due to their pro-inflammatory action, more and attention is paid LDGs, including those expressing enzyme myeloperoxidase (MPO), hepatitis (AIH). LDGs are actively involved formation neutrophil extracellular traps (NETs). This phenomenon may favour externalization autoantigen lead damage internal organs, liver. Aim. The main aim study was assess diagnostic...

The objective of this research conducted in head and neck cancer (HNC) patients was the assessment relationship between neutrophil-to-lymphocyte ratio (NLR) incidence severe radiotherapy (RT) induced oral mucositis (OM), as well overall survival (OS).

(1) Introduction: Autoimmune hepatitis (AIH) is a chronic disease. A persistent autoimmune reaction in the liver significantly related to systemic inflammatory response. Extended Inflammation Parameters (EIP) can be used assess activation of immune cells such as activated neutrophils (NEUT-RI and NEUT-GI) lymphocytes (RE-LYMP AS-LYMP) phase active inflammation. The role response markers should also emphasised, especially: NLR, PLR, RLR, which have recently been widely studied skin diseases...

Every year, about 650 thousand new cases of Head and Neck Cancer (HNC) are diagnosed globally. Apart from surgery, radiotherapy (RTH), chemotherapy (CHT) or its combination is used in the treatment HNC. One most frequent complications and, at same time, limitations RTH oral mucositis (OM). Proinflammatory cytokines (including TNF-α) play a key role development OM. Genetic alterations, i.e. single nucleotide polymorphisms (SNPs) within genes encoding for receptors TNF (ie. TNFRSF1A) may...

Radiotherapy (RTH) usually combined with chemotherapy (C-RTH) is the main method of treatment in head and neck cancer (HNC). The most common complication RTH oral mucositis (OM). At a certain stage RTH, it occurs almost all patients, often lead to discontinuation treatment. Tumour necrosis factor alpha (TNF-α) cytokine secreted during inflammatory process accompanying development itself. Single nucleotide polymorphism (SNP) TNF-α promoter region can potentially affect function or expression...

Introduction: Direct parameters resistance (R), reactance (Xc), phase angle (PA), capacitance of membrane (Cm), and impedance ratio (Z200/Z5)) determined by bioelectrical analysis (BIA) detect changes in tissue electrical properties have been found to be a marker cell function various diseases. Materials Method: The cross-sectional study was conducted investigate whether direct bioimpedance differ group heart failure (HF) patients divided on the basis New York Heart Association (NYHA)...

Introduction: Chronic obstructive pulmonary disease (COPD) affects more than 10% of the world's population over 40 years age.The main exogenous risk factor is cigarette smoking; however, only 20% smokers develop COPD, indicating that some other factors, e.g.genetic, may play an important role in pathogenesis.Recent research indicates ACE (angiotensin-converting enzyme) be a susceptibility gene for asthma or COPD.The aim our study was to determine influence I/D (insertion/deletion)...

Intensified treatment of head and neck cancers (HNC): by radiotherapy (RTH) commonly combined with cytotoxic drugs is associated oral mucositis (OM). Changes in the functioning nucleotide synthesis pathway (RNR1, coded RRM1 gene) can modulate efficiency cellular DNA repair mechanisms influence risk occurrence severity OM HNC patients after RTH.The objective this study was to evaluate correlation between expression gene measured free circulating RNA (cfRNA) more severe disease-free survival...

Nutritional deficiencies, including malnutrition and its irreversible type cachexia, are often observed in patients with head neck cancer (HNC). Among the various factors contributing to occurrence of these disorders, inflammation seems be crucial. The potential regulatory properties miR-511-3p, e.g., post-translational alteration expression genes protein products that involved inflammation, may related nutritional deficiencies HNC patients. Therefore, aim our study was assess correlation...

BACKGROUND:Calprotectin (S100A8/A9 or myeloid-related protein 8/14) is a heterodimeric S100 complex expressed in leukocytes. Calprotectin participates development of the inflammatory response by binding to receptors for advanced glycation end-products (RAGE) and Toll-like (TLR). The clinical activity systemic lupus erythematosus (SLE) evaluated using Systemic Lupus International Collaborating Clinics (SLICC) criteria Erythematosus Disease Activity Index (SLEDAI). This Polish single-center...

MiRNA-8074 is a molecule with the potential to regulate expression of key genes related pathogenesis multiple myeloma (MM), i.e., TP53, MYC, MAPK1, and KIAA. We analyzed predictive prognostic value miRNA-8074 in MM patients. In total, 105 newly diagnosed patients treated thalidomide (n = 27), bortezomib 41) 37) were studied. For miRNA analysis, column method Real-Time PCR technique specific TaqMan Fast Advanced Master Mix probes used. Factors that associated significant reduction...

Multiple myeloma (MM) is the second most common hematological neoplasm. Cytokines, chemokines, and their receptors, induced by microenvironment of MM, participate in tumor growth, attraction leukocytes, cell homing, bone destruction. This study aimed to assess correlation between pretreatment serum concentrations interleukin-6 (IL-6), interleukin-8 (IL-8), angiogenic chemokine monocyte chemoattractant protein-1 (MCP-1), vascular endothelial growth factor (VEGF) clinical outcomes survival...

The study purpose was to examine the correlation between SNP in regulatory region (c.-521G>C, rs4855883) of APEH gene as well incidence and severity radiotherapy (RTH) induced oral mucositis (OM) overall survival (OS) head neck cancer (HNC) patients.OM 62 HNC patients subjected irradiation assessed using RTOG/EORTC scale. DNA isolated from whole blood patients. Mini-sequencing method (SNaPshot PCR) used determine genotype.The following frequency occurrence observed: CC: 37.1%, CG: 43.6% GG:...

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Background: Multiple myeloma (MM) is a hematological neoplasm of the early precursor B-cells. The most characteristic symptoms observed during MM include hypocalcemia, anemia, bacterial infections, and renal damage. Nutritional disorders, especially malnutrition, are noted in about 35–71% patients. Interleukin 1 beta (IL-1β) proinflammatory cytokine responsible for muscle atrophy lipolysis malnutrition cachexia. This study aimed to evaluate usefulness IL1B single-nucleotide polymorphism...

The combination of cisplatin and gemcitabine is still one the most frequently used first-line chemotherapy scheme in patients with advanced non-small cell lung cancer (NSCLC), which tyrosine kinase inhibitors (TKIs) cannot be administered. Unfortunately, more than half have no benefit from but are exposed to its toxic effects. Therefore, single nucleotide polymorphisms (SNPs) genes involved excision repair (NER) mechanism may a potential predictive factor efficiency cytostatic based...

Background: Malnutrition is a nutritional disorder observed in 52% of patients with head and neck cancer (HNC). frequently related to the increased level proinflammatory cytokines. In turn, ongoing inflammation associated catabolism skeletal muscle lipolysis. Tumor necrosis factor α (TNF-α) cytokine that plays pivotal role development malnutrition cachexia patients. The aim study was assess relationship between functional single-nucleotide polymorphism (SNP) −610 T > G (rs4149570)...

The purpose of this study was to investigate the relationship between single nucleotide polymorphisms (SNP; rs1629816) in regulatory region (c.-2531C>T) ghrelin (GHRL) gene and occurrence severity oral mucositis caused by radiotherapy (RT) patients with head neck cancer.Oral 65 cancer who underwent irradiation were assessed according Radiation Therapy Oncology Group (RTOG)/European Organisation for Research Treatment Cancer (EORTC) scale. DNA from isolated whole blood. genotypes determined...