A5078440487- Head and Neck Cancer Studies
- Oral health in cancer treatment
- Nutrition and Health in Aging
- GDF15 and Related Biomarkers
- Body Composition Measurement Techniques
- Chemotherapy-induced cardiotoxicity and mitigation
- Salivary Gland Disorders and Functions
- Effects of Radiation Exposure
- Historical and Cultural Studies of Poland
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Renal cell carcinoma treatment
- Electrical and Bioimpedance Tomography
- Cancer Immunotherapy and Biomarkers
- Adipose Tissue and Metabolism
- Integrated Water Resources Management
- Adipokines, Inflammation, and Metabolic Diseases
- MicroRNA in disease regulation
- Medieval European History and Architecture
- Oral Health Pathology and Treatment
- Inflammation biomarkers and pathways
- Wireless Body Area Networks
- Infrared Thermography in Medicine
- Cancer Diagnosis and Treatment
Medical University of Lublin
2013-2024
Lublin Oncology Center
2019-2020
Malnutrition and cachexia are frequent among head neck cancer (HNC) patients these syndromes associated with both poor quality of life unfavorable disease prognosis. Unfortunately, there still no established biomarkers that could predict the development cachexia. Among potential molecular alterations related to cachexia, single-nucleotide polymorphisms (SNPs) within genes encoding pro-inflammatory cytokines such as TNF-α.To investigate TNF-α -1031T/C SNP a risk factor in 62 HNC subjected...
Investigation of novel cachexia-related markers is one the major challenges in contemporary oncology. Among studied markers, miRNA seems to be promising due its possibility regulate genes responsible for induction inflammatory response, muscle atrophy and fat tissue wasting. The aim study was investigate role blood-circulating miRNA-130a prediction cancer cachexia 70 head neck patients (HNC) subjected radiotherapy. Moreover, diagnostic accuracy SGA (Subjective Global Assessment) scoring...
Every year, about 650 thousand new cases of Head and Neck Cancer (HNC) are diagnosed globally. Apart from surgery, radiotherapy (RTH), chemotherapy (CHT) or its combination is used in the treatment HNC. One most frequent complications and, at same time, limitations RTH oral mucositis (OM). Proinflammatory cytokines (including TNF-α) play a key role development OM. Genetic alterations, i.e. single nucleotide polymorphisms (SNPs) within genes encoding for receptors TNF (ie. TNFRSF1A) may...
Radiotherapy (RTH) usually combined with chemotherapy (C-RTH) is the main method of treatment in head and neck cancer (HNC). The most common complication RTH oral mucositis (OM). At a certain stage RTH, it occurs almost all patients, often lead to discontinuation treatment. Tumour necrosis factor alpha (TNF-α) cytokine secreted during inflammatory process accompanying development itself. Single nucleotide polymorphism (SNP) TNF-α promoter region can potentially affect function or expression...
The ability to undergo neoangiogenesis is a common feature with all cancers. Signaling related vascular endothelial growth factors (VEGF) and their receptors (VEGFR) plays key role in the process of tumor neoangiogenesis. A close relationship has been demonstrated between excessive VEGF levels induction immunosuppression microenvironment. use drugs blocking function, apart from anticancer effect, also result adverse effects, particular circulatory system kidneys. Cardiac toxicity associated...
Apart from surgery, the methods of treatment HNC are radiotherapy (RTH) and/or chemotherapy (CRTH/CHT). One most frequent and serious complications RTH is oral mucositis (OM). There a strict correlation between inflammation status hydration. The aim study was to evaluate changes in hydration, occurring course RTH, measured by means bioelectrical impedance analysis (BIA) analyze them with intensification OM patients.Data 49 patients (stages I-IV) were analyzed. All irradiated using IMRT...
The study purpose was to examine the correlation between SNP in regulatory region (c.-521G>C, rs4855883) of APEH gene as well incidence and severity radiotherapy (RTH) induced oral mucositis (OM) overall survival (OS) head neck cancer (HNC) patients.OM 62 HNC patients subjected irradiation assessed using RTOG/EORTC scale. DNA isolated from whole blood patients. Mini-sequencing method (SNaPshot PCR) used determine genotype.The following frequency occurrence observed: CC: 37.1%, CG: 43.6% GG:...
The purpose of this study was to investigate the relationship between single nucleotide polymorphisms (SNP; rs1629816) in regulatory region (c.-2531C>T) ghrelin (GHRL) gene and occurrence severity oral mucositis caused by radiotherapy (RT) patients with head neck cancer.Oral 65 cancer who underwent irradiation were assessed according Radiation Therapy Oncology Group (RTOG)/European Organisation for Research Treatment Cancer (EORTC) scale. DNA from isolated whole blood. genotypes determined...
The aim of this study was to evaluate the relationship between single nucleotide polymorphism (SNP) (-135 T>C) TNFRSF1 A and frequency occurrence severity oral mucositis (OM) in patients with head neck cancer (HNC) treated radiotherapy (RT).This retrospective, cohort included 60 HNC intensity-modulated radiation therapy (IMRT). SNP analysis performed by using molecular probes (TaqMan, ThermoFisher Scientific, Waltham, MA) DNA isolated from peripheral blood (QIAamp MiniKit; Qiagen,...
Background: The most serious disturbance of the nutritional status is neoplastic cachexia. main factor contributing to development cachexia ongoing inflammatory process. gene associated with response ITGAM. Therefore, aim study was assess relationship between a single nucleotide polymorphism (SNP)-323G>A ITGAM and occurrence disorders in patients undergoing radiotherapy (RT) due head neck cancers (HNC). Methods: involved 71 HNC treated intensity-modulated (IMRT). SNP analysis (-323G>A)...
Abstract Oral mucositis is a common side effect of radiation therapy for head and neck cancer. Severe followed by symptoms, such as extreme pain, mucosal ulceration consequent limitations in swallowing achieving adequate nutritional intake. Mucositis may also increase the risk local systemic infection significantly affect quality life cost care. oral can lead to need interrupt or discontinue cancer thus have an impact on cure primary disease. In spite all advances made understanding...
Introduction. Phase angle (PA) is an indicator based on resistance (R) and reactance (Xc) received from bioelectrical impedance analysis (BIA). Although the biological significance of PA still not clear, it appears to have important prognostic role in nutrition state assessment. Aim. The study aimed investigate differences resistance, phase group Polish men women. Material methods. whole-body analyses were made with ImpediMed bioimpedance SFB7 BioImp v1.55 (Pinkeba Qld 4008, Australia) 30...
The head and neck tumors constitute large complex group. incidence of malnutrition in patients with averages from 65 to 75%. That gives them the third place behind pancreas stomach tumors. correct assessment nutrition helps recognize degree has influence on care therapy. dietary interview, anthropometric methods, bioimpedance labolatory tests are used evaluation nutritional state various scale. an number complications extends period hospitalization, thus methods evaluating commonly clinical...