A5030240767- Bone Tissue Engineering Materials
- Shoulder Injury and Treatment
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Nerve injury and regeneration
- Bone fractures and treatments
- Tendon Structure and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Tissue Engineering and Regenerative Medicine
- Periodontal Regeneration and Treatments
- Nerve Injury and Rehabilitation
- Dental Implant Techniques and Outcomes
- Facial Trauma and Fracture Management
- Graphene and Nanomaterials Applications
- Cardiovascular Function and Risk Factors
- Bone health and osteoporosis research
- Dysphagia Assessment and Management
- Heat shock proteins research
- Protease and Inhibitor Mechanisms
- Knee injuries and reconstruction techniques
- Acute Ischemic Stroke Management
- Connexins and lens biology
- Voice and Speech Disorders
- Cardiac Arrest and Resuscitation
- Electrospun Nanofibers in Biomedical Applications
The Wallace H. Coulter Department of Biomedical Engineering
2021-2025
Georgia Institute of Technology
2022-2025
The University of Texas at San Antonio
2017-2022
The University of Texas Health Science Center at San Antonio
2019
Pennsylvania State University
2010-2012
Abstract Volumetric muscle loss (VML) injury results in the unrecoverable of mass and contractility. Oral delivery formoterol, a β2-adrenergic receptor agonist, produces modest recovery contractility VML-injured mice. The objective this study was to determine if regenerative rehabilitation paradigm or medicine could enhance muscle. Regenerative involved oral formoterol combined with voluntary wheel running. direct using nonbiodegradable poly(ethylene glycol) biomaterial. To approaches were...
Estrogen deficiency in postmenopausal women is a major cause of bone loss, resulting osteopenia, osteoporosis, and high risk for fracture. Connexin 43 (Cx43) hemichannels (HCs) osteocytes play an important role osteocyte viability, formation, remodeling. We showed here that estrogen reduced Cx43 expression HC function. To determine if functional HCs protect loss during deficiency, we adopted ovariectomy model wild-type (WT) two transgenic mice: R76W (dominant-negative mutant inhibiting only...
Abstract Critically sized bone defects are often compounded by infectious complications. The standard of care consists autografts with systemic antibiotics. These injuries and treatments lead to donor site morbidity, antibiotic resistant strains bacteria, end stage amputation. This study proposes an alternative the autograft using a porous, hydroxyapatite (HA) scaffold evaluated without infection Twenty‐four New Zealand white rabbits received either our HA or pulverized (PBA) within...
Rotator cuff tear is a significant problem that leads to poor clinical outcomes due muscle degeneration after injury. The objective of this study was synergistically increase the number proregenerative cells recruited injure rotator through novel dual treatment system, consisting bone marrow mobilizing agent (VPC01091), hypothesized "push" prohealing into blood, and localized delivery stromal cell-derived factor-1α (SDF-1α), "pull" injury site. Immediately tendon in rat, delivered...
In-office or operative injection laryngoplasty requires needle stability for accurate material placement. To date, no reports compare forces based on gauge, bends, length, type temperature. We hypothesize these factors alter and could impact clinical use.Swine larynges were placed in a compression testing machine. Syringes affixed to stabilizing crossbeam. Straight needles (25G 1.5-inch; 27G 1.25-inch; 9.8-inch malleable shaft 16G per oral with 24G tapered tip) inserted into the swine vocal...
Abstract Stimuli–responsive biomaterials may be used to better control the release of bioactive molecules or cells for applications involving drug delivery and controlled cell release. In this study, we developed a Factor Xa (FXa)‐responsive biomaterial capable pharmaceutical agents from in vitro culture. FXa‐cleavable substrates were formed as hydrogels that degraded response FXa enzyme over several hours. Hydrogels shown both heparin model protein FXa. Additionally, RGD‐functionalized...
Cathepsins are a family of cysteine proteases responsible for variety homeostatic functions throughout the body, including extracellular matrix remodeling, and have been implicated in degenerative diseases. However, clinical trials using systemic administration cathepsin inhibitors abandoned due to side effects, so local delivery may be advantageous. In these experiments, novel microfluidic device platform was developed that can synthesize uniform, hydrolytically degradable microparticles...
Regenerating large bone defects requires a multifaceted approach combining optimal scaffold designs with appropriate growth factor delivery. Supraphysiological doses of recombinant human morphogenetic protein 2 (rhBMP2), typically used for the regeneration clinically in conjunction an acellular collagen sponge (ACS), have resulted many complications. In this study, we develop hydroxyapatite/collagen I (HA/Col) to improve mechanical properties HA scaffolds, while maintaining open connected...
Abstract Extracellular matrix (ECM) products have the potential to improve cellular attachment and promote tissue‐specific development by mimicking native niche. In this study, therapeutic efficacy of an ECM substratum produced bone marrow stem cells (BM‐MSCs) regeneration in vitro vivo were evaluated. Fluorescence‐activated cell sorting analysis phenotypic expression employed characterize BM‐MSC response specific (BM‐ECM). BM‐ECM encouraged proliferation stemness maintenance. The as...
A challenge to the development of pediatric ventricular assist devices (PVADs) is use aortic cannulae attached devices. Cannulae used for application have small diameters and large pressure drops. Furthermore, during 12cc Penn State PVAD, particle image velocimetry (PIV) illustrated that hematocrit levels, through changes in blood viscoelasticity, affected fluid dynamics. The objective this study compare dynamics a viscoelastic analog goat within PVAD cannula. Two acrylic models were...
Muscle degeneration after rotator cuff tendon tear is a significant clinical problem. In these experiments, we developed poly(ethylene glycol)-based injectable granular hydrogel containing two heparin derivatives (fully sulfated (Hep) and fully desulfated (Hep-)) as well matrix metalloproteinase-sensitive peptide to promote sustained release of Tumor Necrosis Factor Stimulated Gene 6 (TSG-6) over 14+ days
Muscle degeneration after rotator cuff tendon tear is a significant clinical problem. In these experiments, we developed poly(ethylene glycol)-based injectable granular hydrogel containing two heparin derivatives (fully sulfated [Hep] and fully desulfated [Hep-]) as well matrix metalloproteinase-sensitive peptide to promote sustained release of tumor necrosis factor-stimulated gene 6 (TSG-6) over 14+ days
Deep vein thrombosis (DVT) is a medical condition in which blood clots form the lower extremities, often times right leg, or pelvis region. These are formed through variety of circumstances including: injury to vessel wall, decreased supply, increased clotting factors. Complications from DVT arise when clot breaks free forming pulmonary embolism (PE). The incidence such an occurrence over 600,000 cases per year United States. If PE allowed travel vascular system, occlusion arteries and death...