A5055829699- Veterinary Orthopedics and Neurology
- Veterinary Oncology Research
- Spinal Cord Injury Research
- Hormonal Regulation and Hypertension
- Glioma Diagnosis and Treatment
- Amino Acid Enzymes and Metabolism
- Lysosomal Storage Disorders Research
- Facial Nerve Paralysis Treatment and Research
- Cancer, Lipids, and Metabolism
- Neuroblastoma Research and Treatments
- Hedgehog Signaling Pathway Studies
- Antioxidant Activity and Oxidative Stress
- Colorectal Cancer Screening and Detection
- Teratomas and Epidermoid Cysts
- Coenzyme Q10 studies and effects
- Circular RNAs in diseases
- Neurogenetic and Muscular Disorders Research
- Histiocytic Disorders and Treatments
- Nephrotoxicity and Medicinal Plants
- Oral and Maxillofacial Pathology
- Cancer, Stress, Anesthesia, and Immune Response
- Neurological diseases and metabolism
- Sulfur Compounds in Biology
- Inflammatory Biomarkers in Disease Prognosis
- Colorectal Cancer Surgical Treatments
Kyoto Medical Center
2008-2022
Teikyo University
2019-2021
Towa Pharmaceutical (Japan)
2021
Niigata University
2020
NTT (Japan)
2015-2016
Australia Zoo
2008-2010
The Schwarzman Animal Medical Center
2009-2010
Tokyo Metropolitan Police Hospital
2008
Nagoya University
1963-1993
Liquid biomarkers for the early detection of resistance to chemotherapy are important improving prognosis. This study investigated usefulness plasma exosomal microRNA-125b (ex-miRNA-125b) modified fluorouracil, leucovorin and oxaliplatin (mFOLFOX6)-based first-line in patients with advanced or recurrent (advanced/recurrent) colorectal cancer (CRC). First, ex-miRNAs associated mFOLFOX6-based were profiled via miRNA microarray analysis. In this analysis, ex-miR-125b exhibited greatest...
The introduction of artificial intelligence into the medical field has improved diagnostic capabilities physicians. However, few studies have analyzed economic impact employing technologies in clinical environment. This study evaluated cost-effectiveness a computer-assisted diagnosis (CADx) system designed to support clinicians differentiating early gastric cancers from non-cancerous lesions Japan, where universal health insurance was introduced.The target population be used for CADx...
Histiocytic sarcomas are characterized by proliferation and/or infiltration of neoplastic histiocytes localized to specific organs, unlike malignant histiocytosis which involves many organ systems. Only a few cranial histiocytic have been reported. Here we describe four dogs that presented with neurological deficits referable the forebrain, and were diagnosed histologically as having sarcoma. Using magnetic resonance (MR) imaging, tumors T2‐hyperintense T1‐isointense mass in one dog, T2‐...
Fibrocartilaginous embolism (FCE) is a disorder of acute onset that presents with nonprogressive ataxia. We performed retrospective examination FCE the spinal cord diagnosed by characteristic clinical findings and magnetic resonance imaging (MRI) in 26 dogs. In present study, treatment consisting physiotherapy alone, or this combination corticosteroid administration, was initiated immediately following diagnosis FCE. Age at gender ratio study closely correlated those previously reported. 88%...
Neuronal ceroid-lipofuscinosis (NCL) is a rare group of inherited neurodegenerative lysosomal storage diseases characterized histopathologically by the abnormal accumulation ceroid- or lipofuscin-like lipopigments in neurons and other cells throughout body. The present article describes clinical, pathologic, magnetic resonance imaging (MRI) findings NCL three longhaired Chihuahuas between 16 mo 24 age. Clinical signs, including visual defects behavioral abnormalities, started 18 Cranial MRI...
Intradural disc herniation is a rarely reported cause of neurologic deficits in dogs and few published studies have described comparative imaging characteristics. The purpose this retrospective cross sectional study was to describe clinical findings group with confirmed thoracolumbar intradural herniation. Included were referred one four clinics, had acute mono/paraparesis or paraplegia, low field magnetic resonance (MRI) and/or computed tomographic myelography, diagnosed during surgery....
Abstract Objective To evaluate the ability of extensive hemilaminectomy and durotomy (EHLD) to control progressive myelomalacia (PMM) in dogs. Study design Retrospective clinical study. Animals Twenty‐eight client owned dogs that underwent EHLD (n = 10) or HL alone 18). Methods After diagnosis by MRI, were immediately treated with at site intramedullary hyperintensity on T2‐weighted (T2W)‐MRI. Medical records retrospectively reviewed. Follow‐up data collected via telephone interviews...
Ischemic myelopathy is a disorder of acute onset that characterized by nonprogressive paresis/plegia. Magnetic resonance imaging (MRI) particularly helpful in supporting the antemortem diagnosis ischemic myelopathy. Cats, which were suspected to have between 2005 and 2008, reviewed retrospectively. The nonpainful myelopathy, conduct spine MRI, availability complete medical records included inclusion criteria. presumptive was based on history as well clinical, cerebrospinal fluid, MRI...
GM1 gangliosidosis is a fatal neurodegenerative lysosomal storage disease caused by an autosomal recessively inherited deficiency of β -galactosidase activity. Effective therapies need to be developed treat the disease. In Shiba Inu dogs, one canine models, neurological signs disease, including ataxia, start at approximately 5 months age and progress until terminal stage 12 15 age. present study, serial MR images were taken affected dog from model colony 4 sporadic clinical cases...
A 3-year-old spayed, female, domestic shorthair cat presented in the recumbent position. Clinical examination revealed decreased consciousness and ataxia. Neurological findings suggested a lesion forebrain brainstem, magnetic resonance imaging (MRI) of brain was performed. nodular approximately 1 cm diameter left parietal lobe, overlying temporal observed on MRI scans. T2-weighted images iso- to slightly low-intensity signals cerebral white matter. The detected as by T1-weighted emphasized...
We found odontoclastic resorptive lesions on premolars and molars in a 4- year-old miniature dachshund. The teeth had been extracted because the dentin was resorbed. In some teeth, roots replaced by hard tissue, so we amputated crowns curetted alveolar bone. Histopathological examination revealed that resorbed odontoclasts with bony tissue. Ten months later other treated them along first treatment. At time of writing, since this is report dog same lesion after treatment, hope to establish...
A 2.5-year-old male French Bulldog was evaluated for seizures. Cranial magnetic resonance imaging (MRI) suggested a glioma in the left piriform area. Radiation therapy (RT) and continuous chemotherapy were administered. Although lesion had regressed significantly 2 months after RT, follow-up MRI revealed meningeal enhancement area, which expanded further, with hydrocephalus, by day 310 (8 RT). Because of poor prognosis, dog euthanized on 356 necropsy performed. Histopathological examination...
Many of the reports summarizing neurological disorders in cats considered only a limited disease group(s). There is one large-scale survey on based histopathological viewpoint. We described localizations and frequencies diseases large population that were referred to Kyoto Animal Referral Medical Center between 2009 2016. attempted determine localization lesions at time examination each case classify etiologies these 276 with retrospectively. 174 cases brain region, 14 cervical cord 34...
The aim of this study was to evaluate the prognostic value concurrent measurement serum phosphorylated neurofilament heavy subunit (pNF-H) concentration and intramedullary T2W hyperintensity in paraplegic dogs. Our hypothesis that these would provide a more accurate prediction functional outcome dogs with thoracolumbar intervertebral disc herniation (IVDH). A prospective case-control clinical designed using 94 acute onset IVDH. association pNF-H concentration, on sagittal MRI (T2H/L2), deep...
Watanabe, Yorikatsu M.D.; Terashima, Youichi Akizuki, Tanetaka Ohmori, Kitaro Yoshimura, Kei Sawada, Akifumi Kurakata, Masaru Sugita, Ayanori Ozawa, Tsuyoshi Agawa, Kaori M.D. Author Information
獣医神経病2次施設で紹介を受けた4,131例の犬に対し，中枢神経及び末梢神経筋領域の疾患群での各種疾患の発生割合，犬種の占める発生割合，診断年齢の中央値，発症年齢の範囲を調査した．脳領域が1,583例，頸髄領域（第1頸髄～第2胸髄分節）が743例，胸腰髄領域（第3胸髄～第3仙髄分節）が1,589例，末梢神経筋領域が216例だった．脳領域では特発性てんかん，頸髄及び胸腰髄領域では椎間板ヘルニア，末梢神経筋領域では特発性前庭症候群の罹患割合が高かった．本調査では国内の人気犬種を反映した小型～中型犬種での罹患割合が高く，国外の報告とは異なる傾向だった．単独施設での調査であるため紹介症例に偏りが生じている可能性を考慮すべきだが，本調査は国内における神経病の発生割合などに関する有益な情報である．
A 9-year-old male Shih Tzu with osteosarcoma had a forelimb amputation and underwent chemotherapy. During chemo-theapy, the right eye was enucleated due to refractory glaucoma, diagnosed as anterior uveal malignant melanoma. The dog lived for 4 months after enucleation without treatment. After died, mass in re-evaluated immunohistochemically, it metastasis of appendicular osteosarcoma. Metastasis chamber is quite rare, clinical course which showed clinically detectable metastases before...