A5013989238- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Advanced MRI Techniques and Applications
- Parasite Biology and Host Interactions
- Insect Resistance and Genetics
- Enzyme Production and Characterization
- Anesthesia and Sedative Agents
- Toxin Mechanisms and Immunotoxins
- NMR spectroscopy and applications
- Silk-based biomaterials and applications
- Invertebrate Immune Response Mechanisms
- Gold and Silver Nanoparticles Synthesis and Applications
- Alkaline Phosphatase Research Studies
- Parasitic Infections and Diagnostics
- Lipid Membrane Structure and Behavior
- Erythrocyte Function and Pathophysiology
- Phytase and its Applications
- Nanoplatforms for cancer theranostics
- Toxoplasma gondii Research Studies
- thermodynamics and calorimetric analyses
- Protein Hydrolysis and Bioactive Peptides
- Legionella and Acanthamoeba research
- Insect Pest Control Strategies
- Atomic and Subatomic Physics Research
Universidad San Pablo CEU
2021-2025
Central University of Venezuela
1996-2018
Centro Nacional de Microbiologia
2015
Instituto de Salud Carlos III
2015
Instituto Venezolano de Investigaciones Científicas
1987-2003
Abstract Gold‐coated silver nanoparticles (Ag@AuNPs) are synthesized by green synthesis using Vaccinium corymbosum as reducing agent. The obtained Ag@AuNPs present a core‐shell structure with nanostar shape. absorption spectrum of these shows prominent band centred at 680 nm, within the optimal range for photothermal applications. Dispersions in water, 1.87 10 NPs/mL, reach temperature 44.3 °C under laser excitation minutes, which is suitable hyperthermia therapy. internalization Ag@AuNPs,...
Eukaryotic cells respond to DNA damage by activating checkpoint pathways, which arrest cell cycle progression and induce gene expression. We isolated a full-length cDNA encoding 49-kDa protein from Leishmania major, exhibited significant deduced amino acid sequence homology with the annotated sp. damage-inducible (Ddi1-like) protein, as well Ddi1 Saccharomyces cerevisiae. In contrast previously described L. major displays three domains: (1) an NH2-terminal ubiquitin like; (2) COOH terminal...
Lynx pardinus is one of the world's most endangered felines inhabiting Iberian Peninsula. The present study was performed to identify presence microsporidia due mortality increase in lynxes. Samples urine (n = 124), feces 52), and tissues [spleen 13), brain 9), liver 11), kidney 10)] from 140 lynxes were studied. determination evaluated using Weber's chromotrope stain Real Time-PCR. Of analyzed, stains showed 10.48% 50% positivity samples, respectively. PCR confirmed that 7.69% 65.38%...
Serine proteinase inhibitors (serpins) finely regulate serine activity via a suicide substrate-like inhibitory mechanism. In parasitic nematodes, some serpins interact with host physiological processes; however, little is known about these essential molecules in Anisakis. This article reports the gene sequencing, cloning, expression and preliminary biochemical bioinformatically-based structural characterization of new Anisakis serpin (ANISERP). The full AniSerp was cloned by specific...
The trypanosomatid cytoskeleton is responsible for the parasite's shape and it modulated throughout different stages of life cycle. When parasites are exposed to media with reduced osmolarity, they initially swell, but subsequently undergo compensatory shrinking referred as regulatory volume decrease (RVD). We studied effects anti-microtubule (Mt) drugs on proliferation Leishmania mexicana promastigotes their capacity RVD. All tested exerted antiproliferative varying magnitudes [ansamitocin...
Spin-spin lattice relaxation times T2 have been measured since 1950 with the use of spin echo method. Since then, several modifications introduced in order to overcome technical difficulties. measurement by CPMG method has become very popular, but its performance is sensitive ratio T2/τ, where τ time between pulses. The locking technique gives good results not normally available conventional spectrometers. Recently, a new way measuring was proposed for case proton NMR, which one performs...