A5053529357- Lung Cancer Research Studies
- Cancer therapeutics and mechanisms
- Bioactive Natural Diterpenoids Research
- Neuroendocrine Tumor Research Advances
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Essential Oils and Antimicrobial Activity
- Insect Pest Control Strategies
- Traditional and Medicinal Uses of Annonaceae
- Research on Leishmaniasis Studies
- Drug Transport and Resistance Mechanisms
- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Trypanosoma species research and implications
- Biological Activity of Diterpenoids and Biflavonoids
- Ion Channels and Receptors
- Alkaloids: synthesis and pharmacology
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- Cancer, Lipids, and Metabolism
- Synthesis and Characterization of Heterocyclic Compounds
Central University of Venezuela
2013-2024
Instituto de Estudios Avanzados
2015-2024
Colciencias
2020
Institut Curie
1993-2004
Centre National de la Recherche Scientifique
1993-2003
Institut Gustave Roussy
1993-1996
Laboratoire d'études sur les monothéismes
1992
Abstract Transcription factors are crucial to an understanding of the molecular basis neoplasia. Horneobox‐containing genes a family transcriptional regulators encoding DNA‐binding ho‐meodomains, involved in control normal development. Class‐1 human homeobox‐containing ( HOX genes) display peculiar chromosomal organization, perhaps directly related their function. Aberrant expression homeobox‐genes has been associated with both morphological abnormalities and oncogenesis. We have recently...
Two series of 17 tetrahydroquinoline compounds (2,4-DAr-THQs and DSQs), in which the 4-methoxy-3- hydroxyphenyl (isovanillin) structural unit is incorporated, were tested for their potential human tumor cell growth inhibitory effect on MCF-7, SKBR-3, PC3, HeLa non-tumor cells (primary culture dermis fibroblast – control cells) first time. The THQ 8 an interesting model antitumoral drugs, displaying cytotoxic activity against MCF7, SKBR3 or PC3 (IC50 7.99 - 16.14 μM) with selectivity index...
Background: Patients with small-cell lung carcinomas (SCLCs) initially respond to combination chemotherapy. Only a few benefit in terms of long-term survival because most relapse. Such outcome may be attributable development multi-drug resistance. Purpose : The response SCLC chemotherapy was examined ( ) patient survival, b drug sensitivity tumors patients and tumor xenografts nude mice, c expression multidrug resistance gene MDR1 GST-π gene. Methods Tumor samples obtained from seven...
Analysis of the dichloromethane extract aerial parts Croton cuneatus led to isolation new glutarimide alkaloids: julocrotol (1), isojulocrotol (2), and julocrotone (3) along with known compounds julocrotonine (4), lichexanthone (5) selin-11-en-4α-ol (6). The structures were established by spectral methods. in vitro cytotoxic activity Compounds 1–6 was evaluated against six human tumor cells lines.
Prediction of human tumor response based on preclinical data could reduce the failure rates subsequent new anticancer drugs clinical development. Human small-cell lung carcinomas (SCLC) are characterized by high initial sensitivity to chemotherapy but a low median survival time because drug resistance. The aim this study was evaluate therapeutic relevance panel SCLC xenografts established in our laboratory using one compromising SCLC, topotecan (TPT). Six derived from six patients were used:...
11-Deoxyfistularin-3 (1), a new bromotyrosine derivative, was isolated among other known compounds such as fistularin-3 (2), aerothionin (3), and 11-oxoaerothionin (4) from the Caribbean sponge Aplysinafistularis (Aplysinellidae). The structure of 1 determined by spectroscopic analysis showed in vitro activity against human breast carcinoma cell line MCF-7.
1 Faculty of Science, Institute Food Science and Technology, Central University Venezuela, Postal code 1041-A, zip 47097, Caracas, Venezuela. 2 Pharmacy, Laboratory Natural Products, 3 Experimental Biology, 4 Foundation for Advanced Studies, IDEA,
Many theories mention hypersensitive, promiscuous, outlaw or bypass signalling pathways to explain the acquisition of hormone independence in prostate cancer. Hormonal escape tumours is marked by many biological changes, including mucinous and neuroendocrine differentiation. Since expression several mucins has been linked carcinoma tumour progression, we have characterised at both RNA protein levels an vivo model cancer hormonal escape. Using PAC120, a xenograft human hormone-dependent...