A5011825916- Intensive Care Unit Cognitive Disorders
- Pharmaceutical Practices and Patient Outcomes
- Patient Safety and Medication Errors
- Healthcare Technology and Patient Monitoring
- Alcoholism and Thiamine Deficiency
- Anesthesia and Sedative Agents
- Pharmacovigilance and Adverse Drug Reactions
- Electronic Health Records Systems
- Sepsis Diagnosis and Treatment
- Ultrasound in Clinical Applications
- Family and Patient Care in Intensive Care Units
- Emergency and Acute Care Studies
- Acute Kidney Injury Research
- Electrolyte and hormonal disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Venous Thromboembolism Diagnosis and Management
- Health Systems, Economic Evaluations, Quality of Life
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Drug-Induced Adverse Reactions
- Healthcare Decision-Making and Restraints
- Poisoning and overdose treatments
- Cancer Treatment and Pharmacology
- Diet and metabolism studies
- Nursing Roles and Practices
King's College Hospital
2022-2025
American College of Clinical Pharmacy
2025
Beth Israel Deaconess Medical Center
2019-2025
King's College Hospital NHS Foundation Trust
2022-2024
McMaster University
2024
MCPHS University
2017-2023
Vrije Universiteit Brussel
2022
Brigham and Women's Hospital
2016-2020
National Patient Safety Foundation
2017-2020
University of Pittsburgh
2018-2020
Abstract There is a need to understand contemporary scientific advances as clinical pharmacy evolves. One rapidly expanding area artificial intelligence (AI), which has grown significantly over the past year because of public availability large language models. This commentary reviews published literature describing and evaluating applications AI each aspect medication use process forecasts potential future roles for in practice. Potential challenges implementation are also described.
To define the types and numbers of inpatient clinical decision support alerts, measure frequency with which they are overridden, describe providers' reasons for overriding them appropriateness those reasons.We conducted a cross-sectional study medication-related alerts over 3-year period at 793-bed tertiary-care teaching institution. We measured rate alert overrides, overrides by type, cited reasons.Overall, 73.3% patient allergy, drug-drug interaction, duplicate drug were though varied type...
Background: Adjunctive medications to manage alcohol withdrawal syndrome (AWS) in patients not adequately responding escalating doses of benzodiazepines (BZDs) are limited. The use the N-methyl-d-aspartate antagonist ketamine, may serve as an effective adjunct agent; however, no published data currently exist for this practice. Objective: To determine safety and efficacy ketamine management AWS. Methods: study was a retrospective review adult from April 2011 March 2014 who were administered...
Background Clinical decision support (CDS) displayed in electronic health records has been found to reduce the incidence of medication errors and adverse drug events (ADE). Recent data suggested that medication-related CDS alerts were frequently over-ridden, often inappropriately. Patients intensive care unit (ICU) are at an increased risk ADEs; however, limited exist on benefits ICU. This study aims evaluate potential harm associated with over-rides Methods was a prospective observational...
Abstract Objective To estimate the national cost of ADEs resulting from inappropriate medication-related alert overrides in U.S. inpatient setting. Materials and Methods We used three different regression models (Basic, Model 1, 2) with model inputs taken medical literature. A random sample 40 990 adult inpatients at Brigham Women’s Hospital (BWH) Boston a total 1 639 294 medication orders was taken. extrapolated BWH using 2014 National Inpatient Sample (NIS) data. Results Using models, we...
Abstract Objective The study sought to determine frequency and appropriateness of overrides high-priority drug-drug interaction (DDI) alerts whether adverse drug events (ADEs) were associated with in a newly implemented electronic health record. Materials Methods We conducted retrospective overridden DDI occurring from April 1, 2016, March 31, 2017, inpatient outpatient settings at an academic center. studied highest-severity DDIs that previously designated as “hard stops” additional...
BACKGROUND The 2012 American College of Chest Physicians venous thromboembolism prevention guidelines emphasized the importance considering patient preferences when ordering prophylaxis. OBJECTIVE Determine regarding pharmacologic DESIGN Single‐center, mixed‐methods survey. SETTING Academic medical center. PATIENTS Consecutive hospitalized patients on surgical and units. MEASUREMENTS Patients were asked about their route administration for prophylaxis rationale preference. Qualitative...
Medication-related clinical decision support (CDS) has been identified as a method to improve patient outcomes but is historically frequently overridden and may be inappropriately so. Patients in the intensive care unit (ICU) are at higher risk of harm from adverse drug events (ADEs) these overrides increase harm. The objective this study determine appropriateness medication-related CDS ICU. We evaluated alerts four alert categories January 2009 December 2011. primary outcome was random...
Background: Severe alcohol withdrawal syndrome (SAWS) is highly morbid, costly, and common among hospitalized patients, yet minimal evidence exists to guide inpatient management. Research needs in this field are broad, spanning the translational science spectrum. Goals: This research statement aims describe what known about SAWS, identify knowledge gaps, offer recommendations for each domain of Institute Medicine T0-T4 continuum advance care patients who experience SAWS. Methods: Clinicians...