A5065583071- Pharmaceutical Practices and Patient Outcomes
- Electronic Health Records Systems
- Patient Safety and Medication Errors
- Pharmaceutical studies and practices
- Potassium and Related Disorders
- Healthcare Technology and Patient Monitoring
- Venous Thromboembolism Diagnosis and Management
- Pharmacovigilance and Adverse Drug Reactions
- Heart Failure Treatment and Management
- Asthma and respiratory diseases
- Chronic Disease Management Strategies
- Biomedical Text Mining and Ontologies
- Emergency and Acute Care Studies
- Palliative Care and End-of-Life Issues
- Diabetes Treatment and Management
- Healthcare Systems and Technology
- Electrolyte and hormonal disorders
- Drug-Induced Adverse Reactions
- Pharmacy and Medical Practices
- Pneumonia and Respiratory Infections
- Patient-Provider Communication in Healthcare
- Genomics and Rare Diseases
- Intensive Care Unit Cognitive Disorders
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
University of Lucerne
2023-2025
Harvard University
2014-2023
University Hospital of Zurich
2014-2023
University of Zurich
2013-2023
Brigham and Women's Hospital
2014-2023
Swissmedic
2023
University of Lausanne
2021
National Patient Safety Foundation
2017-2018
To define the types and numbers of inpatient clinical decision support alerts, measure frequency with which they are overridden, describe providers' reasons for overriding them appropriateness those reasons.We conducted a cross-sectional study medication-related alerts over 3-year period at 793-bed tertiary-care teaching institution. We measured rate alert overrides, overrides by type, cited reasons.Overall, 73.3% patient allergy, drug-drug interaction, duplicate drug were though varied type...
GLP-1R (glucagon-like peptide-1 receptor) agonists are approved to treat type 2 diabetes mellitus and obesity. reduce airway inflammation hyperresponsiveness in preclinical models.
In 2013, the Global Coalition for Regulatory Science Research (GCRSR) was established with members from over ten countries (www.gcrsr.net). One of main objectives GCRSR is to facilitate communication among global regulators on rise new technologies regulatory applications through annual conference Summit (GSRS). The 11th GSRS (GSRS21) focused "Regulatory Sciences Food/Drug Safety Real-World Data (RWD) and Artificial Intelligence (AI)." discussed current advancements in both AI RWD approaches...
Background Clinical decision support (CDS) displayed in electronic health records has been found to reduce the incidence of medication errors and adverse drug events (ADE). Recent data suggested that medication-related CDS alerts were frequently over-ridden, often inappropriately. Patients intensive care unit (ICU) are at an increased risk ADEs; however, limited exist on benefits ICU. This study aims evaluate potential harm associated with over-rides Methods was a prospective observational...
BACKGROUND: Digital tools are widely utilised to improve communication and information exchange among healthcare professionals. The cantonal hospital in Lucerne was the first implement Epic clinical system a German-speaking country, including access for primary care physicians via an electronic health record portal. OBJECTIVES: This study assessed how perceive with hospitals canton of Lucerne, their preferences discharge summary contents experiences utilisation regionally implemented...
Objectives To evaluate how often and why providers overrode drug allergy alerts in both the inpatient outpatient settings. Design A cross-sectional observational study of generated over a 3-year period between 1 January 2009 31 December 2011. Setting 793-bed tertiary care teaching affiliate Harvard Medical School 36 primary practices. Participants Drug were displayed for total 29 420 patients across Main outcome measures Proportion overridden, proportion appropriate overrides, overrides each...
Medication-related clinical decision support (CDS) has been identified as a method to improve patient outcomes but is historically frequently overridden and may be inappropriately so. Patients in the intensive care unit (ICU) are at higher risk of harm from adverse drug events (ADEs) these overrides increase harm. The objective this study determine appropriateness medication-related CDS ICU. We evaluated alerts four alert categories January 2009 December 2011. primary outcome was random...
To analyze the patterns of potentially avoidable readmissions due to adverse drug events (ADEs) identify most appropriate risk reduction interventions.In this observational study, we analyzed a random sample 534 30-day from 10,275 consecutive discharges medical department an academic hospital. Readmissions ADEs were reviewed causative drugs and severity interventions prevent them.Seventy cases (13.1%) readmission partially or predominantly ADEs, which, 58 (82.9%) serious ADEs. Overall, 65...
Adverse drug reactions (ADRs) contribute to morbidity, and serious ADRs may cause hospitalisation death. This study characterises quantifies ADR-related hospitalisations subsequent in-hospital deaths, estimates the spontaneous reporting rate regulatory authorities in Switzerland, where healthcare professionals are legally obliged report ADRs. retrospective cohort from 2012 2019 analysed nationwide data Federal Statistical Office. ICD-10 coding rules identified hospitalisations. To estimate...
Clinical decision support has the potential to improve prevention of venous thromboembolism (VTE). The purpose this prospective study was analyze effect electronic reminders on thromboprophylaxis rates in wards which patients were admitted and transferred. latter particular interest since patient handoffs are considered be critical safety issues.The trial involved two periods six departments a university hospital, three randomly assigned intervention group displaying during second period. At...
Background: Multimorbidity, defined as the co-occurrence of ≥2 chronic conditions, is clinically diverse. Such complexity hinders development integrated/collaborative care for multimorbid patients. In addition, universality multimorbidity patterns unclear given scarce research comparing profiles across populations. This study aims to derive and compare in Hong Kong (HK, PRC) Zurich (ZH, Switzerland). Methods: Stratified by sites, hierarchical agglomerative clustering analysis (dissimilarity...
Abstract Background During transitions of care, including hospital discharge, patients are at risk drug-related problems (DRPs). Aim To investigate the impact pharmacist-led services, specifically medication reconciliation admission and/or interprofessional ward rounds on number DRPs discharge. Method In this retrospective, single-center cohort study, we analyzed routinely collected data discharged from internal medicine wards a regional Swiss that filled their discharge prescriptions in...
Advanced electronic alerts (eAlerts) and computerised physician order entry (CPOE) increase adequate thromboprophylaxis orders among hospitalised medical patients. It remains unclear whether eAlerts maintain their efficacy over time, after withdrawal of continuing education (CME) on indications from the study staff. We analysed 5,317 hospital cases University Hospital Zurich during 2006-2009: 1,854 a ward with (interventiongroup) 3,463 surgical without (controlgroup). In intervention group,...
A recent review identified 19 anticholinergic burden scales (ABSs) but no study has yet compared the impact of all ABSs on delirium. We evaluated whether a high as classified by each ABS is associated with incident delirium.We performed retrospective cohort in Swiss tertiary teaching hospital using data from 2015-2018. Included were patients aged ≥65, hospitalised ≥48 hours stay >24 intensive care. Delirium was defined twofold: (i) ICD-10 or CAM and (ii) DOSS. Patients' cumulative score,...
Abstract Background Experts suggest that formulary alerts at the time of medication order entry are most effective form clinical decision support to automate management. Objective Our objectives were quantify frequency inappropriate nonformulary (NFM) alert overrides in inpatient setting and provide insight on how design could be improved. Methods Alert top 11 ( n = 206) most-utilized highest-costing NFMs, from January 1 December 31, 2012, randomly selected for appropriateness evaluation....
Abstract Objective Variation in the use of tests and treatments has been demonstrated to be substantial between providers geographic regions. This study assessed variation outpatient overriding electronic prescribing warnings. Methods Responses warnings were prospectively logged. Random effects models used calculate provider-to-provider rates for decisions override 6 different clinical domains: medication allergies, drug-drug interactions, duplicate drugs, renal recommendations, age-based...