A5088255840- Cancer Genomics and Diagnostics
- Cytomegalovirus and herpesvirus research
- interferon and immune responses
- RNA modifications and cancer
- Single-cell and spatial transcriptomics
- RNA regulation and disease
- Mycobacterium research and diagnosis
- Cancer-related molecular mechanisms research
Harbin Medical University
2022-2024
Numerous variants, including both single-nucleotide variants (SNVs) in DNA and A>G RNA edits mRNA as essential drivers of cellular proliferation tumorigenesis, are commonly associated with cancer progression growth. Thus, mining summarizing single-cell will provide a refined higher-resolution view further contribute to precision medicine. Here, we established database, CanCellVar, which aims visualize the comprehensive atlas tumor microenvironment. The current CanCellVar identified ∼3...
Single nucleotide variants (SNVs), as important components of genetic variation, affect gene expression, function and phenotype. Mining summarizing the spatial distribution SNVs in diseased normal tissues for a better understanding their characteristics potential roles cell-lineage determination, aging, or disease occurrence is significant. Herein, we have developed comprehensive mutation resource stSNV (http://bio-bigdata.hrbmu.edu.cn/stSNV/index.jsp), which provides an atlas major human...
Abstract The distribution and extent of immune cell infiltration into solid tumors play pivotal roles in cancer immunology therapy. Here we introduced an long non-coding RNA (lncRNA) signature-based method (ILnc), for estimating the abundance 14 types from lncRNA transcriptome data. Performance evaluation through pure data shows that our signature sets can be more accurate than protein-coding gene signatures. We found signatures are significantly enriched to functions pathways, such as...