A5075656468- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- Wireless Body Area Networks
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Molecular Communication and Nanonetworks
- Cancer-related molecular mechanisms research
- Mycobacterium research and diagnosis
- Computational Physics and Python Applications
Harbin Medical University
2022-2024
Numerous variants, including both single-nucleotide variants (SNVs) in DNA and A>G RNA edits mRNA as essential drivers of cellular proliferation tumorigenesis, are commonly associated with cancer progression growth. Thus, mining summarizing single-cell will provide a refined higher-resolution view further contribute to precision medicine. Here, we established database, CanCellVar, which aims visualize the comprehensive atlas tumor microenvironment. The current CanCellVar identified ∼3...
Abstract Communications between tumor cells and surrounding immune help shape the immunity continuum. Recent breakthroughs in high-throughput technologies as well computational algorithms had reported many important tumor-immune cell (TIC) communications, which were scattered thousands of published studies impeded systematical characterization TIC communications across cancer. Here, a comprehensive database, TICCom, was developed to model containing 739 experimentally-validated or...
Abstract The distribution and extent of immune cell infiltration into solid tumors play pivotal roles in cancer immunology therapy. Here we introduced an long non-coding RNA (lncRNA) signature-based method (ILnc), for estimating the abundance 14 types from lncRNA transcriptome data. Performance evaluation through pure data shows that our signature sets can be more accurate than protein-coding gene signatures. We found signatures are significantly enriched to functions pathways, such as...