A5078908992- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Sulfur Compounds in Biology
- Molecular Sensors and Ion Detection
- Polydiacetylene-based materials and applications
- Quinazolinone synthesis and applications
- Analytical Chemistry and Sensors
- Catalytic Cross-Coupling Reactions
- Synthesis and Characterization of Heterocyclic Compounds
- Conducting polymers and applications
- Synthetic Organic Chemistry Methods
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Hepatitis B Virus Studies
- Gas Sensing Nanomaterials and Sensors
- Photodynamic Therapy Research Studies
- melanin and skin pigmentation
- Phenothiazines and Benzothiazines Synthesis and Activities
- Sulfur-Based Synthesis Techniques
- Perovskite Materials and Applications
- PI3K/AKT/mTOR signaling in cancer
Nanjing University
2019-2022
Collaborative Innovation Center of Advanced Microstructures
2022
Zunyi Medical University
2016-2020
Beijing Institute of Technology
2018-2019
Wenzhou University
2015
State Council of the People's Republic of China
2015
Air Force General Hospital PLA
2012
Real-time imaging of intracellular glutathione in response to cisplatin by a ratiometric fluorescent probe reveals that the different trends GSH levels is crucial distinguishing cisplatin-resistant from cisplatin-sensitive cells.
A series of branched π-conjugated small molecular red aggregation-enhanced emission probes have been synthesized for mechanochromic applications and cell imaging.
AIE-active positional isomers, TTE-o-PhCHO, TTE-m-PhCHO and TTE-p-PhCHO, tetrathienylethene (TTE) derivates with peripherally attached ortho-/meta-/para-formyl phenyl groups, were designed synthesized. The formyl substitution position can effectively modulate their photophysical properties, mechanochromism fluorescent response to hydrazine. TTE-o-PhCHO exhibit remarkable AIE characteristics, TTE-p-PhCHO possesses aggregation-induced emission enhancement performance. They all high contrast...
Our knowledge in how extracellular vesicles (EVs) are secreted from cells remains inadequate due to the limited technologies available for visualizing them situ. We report a pH-reversible boron dipyrromethene (BODIPY) fluorescent probe confocal imaging of EVs living without inducing severe cytotoxicity. This predominantly assumes non-fluorescent leuco-BODIPY form under basic conditions, but it gradually switches its parent BODIPY upon acidification; such pH transition empowers acidic (such...
The first example of palladium-catalyzed Suzuki-Miyaura coupling between benzyl sulfonates and arylboronic acids was reported in this paper. In the presence a well-defined, air-stable easily available NHC-Pd(II)-Im complex, all reactions worked well to give desired products good almost quantitative yields under optimal conditions. Electron-rich, -neutral, -poor sterically-hindered substituents on both substrates are tolerated such transformation, providing convenient, efficient alternative...
A highly selective NIR fluorescent turn-on probe for hydroxyl radical (·OH) has been built up using triphenylphosphine as a reactive-site ·OH in an energy transfer cassette 2b consisting of 8-2'-(thiophen-2-yl) quinoline (TQ) donor and 3,5-diphenylphosphinostyryl-substituted BODIPY acceptor, which exhibits ca. 317 nm pseudo Stokes' shift due to efficient through-bond (up 169%). The substituent selectively oxidized by over the other reactive oxygen species (ROS) nitrogen (RNS) resulting...
A new class of BOPPY derivatives has been facilely synthesized by a two-step reaction coupling 3,5-dimethylpyrrole-2-carbaldehyde with 2,3-dihydrazinoquinoxaline (QDH) followed coordinating BF3·OEt2. The mainly produces triboron complex 3 within 1 h, while pair B-O-B bridged trans-cis isomers 4 and 4' are formed as the time elongates to 8 h. Moreover, two bromide products 4Br 4Br' prepared almost quantitatively bromination 4', respectively. coordinated B-N bonds impede free rotation bridge,...
Abstract Real-time monitoring of newly acidified organelles during autophagy in living cells is highly desirable for a better understanding intracellular degradative processes. Herein, we describe reaction-based boron dipyrromethene (BODIPY) dye containing strongly electron-withdrawing diethyl 2-cyanoacrylate groups at the α-positions. The probe exhibits intense red fluorescence acidic or cytosol while exhibiting negligible other regions cell. underlying mechanism nucleophilic reaction...
To strengthen the potency of quinazoline core, we designed and synthesized three novel quinazoline-phenyl chlormethine conjugates (I-III) bearing a Schiff base (C=N) linker. Due to compound II effectively suppressed hepatocellular cancer (HepG2) cell growth than other two compounds in our preliminary experiment, was thus selected for further anti-cancer In summary, findings reveal that II, synthetical phenyl chlormethinequinazoline combi-molecules, significantly induces apoptosis liver both...
Abstract A simple, environmentally friendly, one-pot method for the synthesis of 4-aminoquinazolines using microwave irradiation has been developed. Structures derivatives 3 , 4 and 5 were confirmed by single-crystal X-ray diffraction. The in vitro cytotoxicity each compound was investigated an MTT assay with A549 HepG2 cell lines to calculate half-maximal inhibitory concentrations.
Objective To observe the increasing effect of infrared irradiation on tyrosinase activity and melanin content in cultured normal human epidermal melanocytes vitro to explore optimal dose irradiation.Methods Epidermal were isolated from foreskin tissue,and subjected primary culture.Methyl thiazolyl tetrazolium (MTT) assay was performed evaluate different doses(0,20,60,80,100,140,240,320 J/cm2)of light proliferation select dose.Then,melanocytes irradiated with at for 3 consecutive days...
Abstract A single homogeneous spherical polyacetone acrylamide particles was synthesized by inverse suspension polymerization. By adjusting the conditions of initiator, cross-linking agent, dispersant, water-oil ratio, reaction time and temperature, adsorbent material with large specific surface area pore structure obtained. Polyacetone can effectively detect aniline ultraviolet obsorption spectroscopy, adsorption rate reaches 41.95% within 2 hours, equilibrium 5 51.30%.