A5060344145- Renal and related cancers
- Developmental Biology and Gene Regulation
- Neonatal and fetal brain pathology
- Cancer Genomics and Diagnostics
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- RNA regulation and disease
- Memory and Neural Mechanisms
- Epilepsy research and treatment
- Drug-Induced Hepatotoxicity and Protection
- Endoplasmic Reticulum Stress and Disease
- Advanced MRI Techniques and Applications
- MicroRNA in disease regulation
- Circadian rhythm and melatonin
- Alzheimer's disease research and treatments
- Retinal Development and Disorders
- Toxic Organic Pollutants Impact
- Birth, Development, and Health
- Drug Transport and Resistance Mechanisms
- Restraint-Related Deaths
- Lysosomal Storage Disorders Research
- Effects and risks of endocrine disrupting chemicals
- Child Abuse and Related Trauma
- Pharmacogenetics and Drug Metabolism
- Glioma Diagnosis and Treatment
Rigshospitalet
2017-2024
Copenhagen University Hospital
2017-2024
University of Copenhagen
2009-2023
University of Oxford
2017-2019
John Radcliffe Hospital
2017-2019
Bispebjerg Hospital
2006-2010
Abstract The rhesus monkey is widely used as an experimental animal model in the study of brain function and disease. While previous quantitative studies have provided knowledge regional numbers, little known total neocortical neuron glial cell numbers this species. aim to establish norms. We use optical fractionator Cavalieri principle examine right hemisphere eight young monkeys taken from control group ongoing study. Applying these methods agar‐embedded vibratome‐sectioned tissue, we...
BACKGROUNDPrenatal exposure to maternal cigarette smoking or compounds of smoke is associated with serious reproductive hazards such as apoptotic death oogonia in murine offspring and decreased fecundability human offspring. The present study addresses potential effects utero smoking.
In rodents, the Otx2 gene is expressed in diencephalon, mesencephalon, and cerebellum crucial for development of these brain regions. Together with Otx1, known to cooperate other genes develop caudal forebrain and, further, Otx1 also involved differentiation young neurons deeper cortical layers. We have studied spatial temporal expression two homeobox OTX2 OTX1 human fetal brains from 7 14 weeks postconception by situ hybridization immunohistochemistry. was choroid plexus, a minor basal...
We studied the spatial and temporal expression of homeobox genes PAX6, OTX2, OTX1 using a developmental series human fetal eyes aged from 6 to 10 weeks post-conception. Previous animal studies have shown that PAX6 may regulate progenitor cell proliferation, timing differentiation neural retina fate determination. OTX2 play role in development retinal pigment epithelium photoreceptor differentiation, whereas be important ciliary body development. In this study, we demonstrate presence mRNAs...
The development of the human neocortex is a complex and highly regulated process involving time-related expression many transcription factors including homeobox genes <i>Pax6</i> <i>Meis2</i>. During early development,<i> Pax6</i> expressed in nuclei radial glia cells neocortical proliferative zones controls differentiation neurogenetic fate these dorsal telencephalon rodents. Animal studies on <i>Meis2 </i>gene have revealed developing...
Abstract Background In 2016, genomic profiling was implemented for patients with grade 4 primary brain tumors at Rigshospitalet, Denmark. The aim of this study to discover actionable alterations and match these targeted therapies. Methods Between January 2016 December 2023, 483 tumor were profiled. We retrieved clinical data molecular data. Whole exome, whole genome, or panel sequencing, along SNP array analyses, RNA-seq performed on resected tissue. Alterations classified according the...
The authors declare no conflicts of interest.
A 44-year-old Caucasian woman presented with a history of empirical treatment 20 pain and psychotropic medications, as well dual comorbidity intractable depression. multiple gain-of-function profile in the CYP450 family cytochrome P450 (CYP450) drug metabolism isoenzymes was discovered. The patient homozygote suprafunctional alleles for both CYP2D6 (*35/*35) CYP2C19 (*17/*17) genes functional CYP2C9 (*1/*1), which account aggregate function at upper 1% population. improved clinically...
Objective. Histopathological examinations will diminish as minimally invasive epilepsy surgery increasingly replaces open surgery. The objective of this study was to test if visual and computer-aided quantitative analyses presurgical high-quality 3 Tesla MRIs complying with the International League Against Epilepsy (ILAE) Neuroimaging Task Force recommendations can inform on histopathological diagnosis. Methods. Ninety-two patients from Copenhagen Oslo University Hospitals fulfilled...