A5012934107- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Catalytic Cross-Coupling Reactions
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Oxidative Organic Chemistry Reactions
- Catalytic C–H Functionalization Methods
- Synthesis of Indole Derivatives
- Synthesis and Biological Activity
- Advanced Synthetic Organic Chemistry
- Chemical synthesis and alkaloids
- Cyclopropane Reaction Mechanisms
- Radical Photochemical Reactions
- Asymmetric Hydrogenation and Catalysis
- Biological Activity of Diterpenoids and Biflavonoids
- Axial and Atropisomeric Chirality Synthesis
- Multicomponent Synthesis of Heterocycles
- Chemical Synthesis and Reactions
- Sulfur-Based Synthesis Techniques
- Synthesis of β-Lactam Compounds
- Ethnobotanical and Medicinal Plants Studies
- Mesoporous Materials and Catalysis
- Chromatography in Natural Products
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Power Systems and Technologies
Wuhan University of Technology
2012-2024
Université Paris Sciences et Lettres
2020
ESPCI Paris
2020
Délégation Paris 6
2020
RWTH Aachen University
2015-2018
FH Aachen
2016-2018
Dalian University
2016
Dalian University of Technology
2016
Hunan Normal University
2015
Changsha University
2015
An asymmetric organocatalytic domino oxa-Michael/1,6-addition reaction of ortho-hydroxyphenyl-substituted para-quinone methides and isatin-derived enoates has been developed. In the presence 5 mol % a bifunctional thiourea organocatalyst, this scalable affords 4-phenyl-substituted chromans bearing spiro-connected oxindole scaffolds three adjacent stereogenic centers in good to excellent yields (up 98 %) with very high stereoselectivities >20:1 d.r., >99 ee).
The first copper-catalyzed highly chemo-, regio-, diastereo-, and enantioselective Kinugasa/Michael domino reaction for the desymmetrization of prochiral cyclohexadienones is described. In presence a chiral copper catalyst, alkyne-tethered couple with nitrones to generate spirocyclic lactams excellent stereoselectivity (up 97 % ee, >20:1 dr). new method provides direct access versatile functionalized β-lactams possessing four contiguous stereocenters, including one quaternary...
Abstract The highly enantioselective organocatalytic addition of ethyl nitroacetate to isatin‐derived N‐Boc ketimines (Boc= tert ‐butoxycarbonyl), followed by the removal nitro group, is described. scalable reaction sequence leads title compounds as important intermediates pyrroloindoline alkaloids and related drugs in excellent yields enantioselectivities. synthesis hexahydrofurano[2,3‐ b ]indole skeleton, spirocarbamate oxindole unit, formal AG‐041R have been carried out demonstrate...
Abstract An asymmetric organocatalytic domino oxa‐Michael/1,6‐addition reaction of ortho ‐hydroxyphenyl‐substituted para ‐quinone methides and isatin‐derived enoates has been developed. In the presence 5 mol % a bifunctional thiourea organocatalyst, this scalable affords 4‐phenyl‐substituted chromans bearing spiro‐connected oxindole scaffolds three adjacent stereogenic centers in good to excellent yields (up 98 %) with very high stereoselectivities >20:1 d.r., >99 ee ).
A novel hollow-structured Mn/TS-1 catalyst has been reported as a non-nitric acid route for adipic production from oxidative cleavage of cyclohexanone.
An NHC-catalyzed Michael/Michael/esterification domino reaction <italic>via</italic> homoenolate/enolate intermediates for the asymmetric synthesis of tetrasubstituted cyclopentanes is described.
Abstract The efficient asymmetric synthesis of highly substituted succinimides from α,β‐unsaturated aldehydes and α‐ketoamides via NHC‐catalyzed [3+2] cycloaddition has been developed. new scalable protocol significantly expands the utility NHC catalysis for heterocycles provides easy access to assemble a wide range simple starting materials.
Abstract The first copper‐catalyzed highly chemo‐, regio‐, diastereo‐, and enantioselective Kinugasa/Michael domino reaction for the desymmetrization of prochiral cyclohexadienones is described. In presence a chiral copper catalyst, alkyne‐tethered couple with nitrones to generate spirocyclic lactams excellent stereoselectivity (up 97 % ee , >20:1 dr). new method provides direct access versatile functionalized β‐lactams possessing four contiguous stereocenters, including one quaternary...
An efficient and unprecedented [4+3] cycloaddition between in situ generated aza-<i>o</i>-quinone methides azomethine imines via an aza-Michael/aminalization sequence has been developed. The scalable protocol allows to expeditiously assemble a valuable heterocyclic system incorporating tetrahydroisoquinoline benzotriazepine scaffolds good excellent yields under mild conditions.
The first example of an N-heterocyclic carbene-catalyzed asymmetric desymmetrization enal-tethered cyclohexadienones <italic>via</italic> intramolecular homoenolate Michael addition/esterification reaction is described.
A copper-catalyzed cascade reaction of α-diazocarbonyl compounds with ethenesulfonyl fluoride for the construction pyrazole-containing aliphatic sulfonyl fluorides is developed.
The trivalent phosphine-catalyzed [4+1] spiro-annulation reaction of allenyl imide and activated methylene cyclocompounds has been developed for the construction various spiro-2-cyclopenten-1-ones. Oxindoles, 3-isochromanones, 2-indanones are selected as 1C synthons to capture in situ-generated bis-electrophilic α,β-unsaturated ketenyl phosphonium intermediate, affording corresponding monospiro- bispiro-cyclopentenones good excellent yields (≤91%) under mild conditions. primary attempt at...
Disclosed was deoxygenation of allyl arylsulfones to access thioethers using phosphines under photoredox conditions by a “cut-sew” strategy.
2-Alkanoyl-3-aryl-5-hydroxy pyrrolidines were prepared in high yields and ees <italic>via</italic> a secondary amine catalyzed tandem process.
A highly efficient regio- and stereoselective Heck-Matsuda method was developed employing aryl diazoniums allylsulfonyl fluorides for the construction of a class novel γ-aryl in presence Pd(OAc)2 PPh3. The features excellent stereoselectivity (up to 100% E-selectivity), broad substrate scope mild reaction conditions. Further application fluoride SuFEx reactions achieved provide their corresponding sulfonates sulfonamides yields.
Abstract An asymmetric NHC‐catalyzed formal [3 + 2] cycloaddition of α,β‐unsaturated aldehydes with α‐ketoamides is developed to yield functionalized succinimides (III) and (V) good diastereo‐ excellent enantioselectivity.
Abstract A variety of title compounds is available with moderate to good yields and excellent enantioselectivity as intermediates pyrroloindoline alkaloids.
Abstract In the described approach two C—C bonds are formed via Michael addition and one C—O bond through a terminating ethanolysis step.
This paper presents seismic dynamic response rules of Wuhan Changjiang River tunnel. Bilateral responses tunnel typical geology section are studied based on software ANSYS. Conditions gravity and water pressure considered compared with that no gravity. Some conclusions have been obtained:(1)The node displacement lining arch crown is the biggest ,which soffit least under two-way earthquake. The maximal not considering initial condition decreases 34 percent, relative reduces 22 percent between...