A5062632023- Phase Equilibria and Thermodynamics
- Ionic liquids properties and applications
- Thermodynamic properties of mixtures
- Chemical and Physical Properties in Aqueous Solutions
- Polymer Foaming and Composites
- Crystallization and Solubility Studies
- Analytical Chemistry and Chromatography
- Chemical Thermodynamics and Molecular Structure
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Adsorption, diffusion, and thermodynamic properties of materials
- Catalysis and Oxidation Reactions
- Electrocatalysts for Energy Conversion
- Slime Mold and Myxomycetes Research
- Electrochemical Analysis and Applications
- Fuel Cells and Related Materials
- Biochemical Acid Research Studies
- Glioma Diagnosis and Treatment
- Innovative concrete reinforcement materials
- Process Optimization and Integration
- Fungal Biology and Applications
- Biopolymer Synthesis and Applications
- Synthetic Organic Chemistry Methods
- Advanced Battery Technologies Research
- Free Radicals and Antioxidants
Kangwon National University
2007-2025
Kyungnam University
2016-2019
Cedars-Sinai Medical Center
2006-2018
National Taiwan University
2012-2017
University of Regensburg
1999-2006
Glioblastoma multiforme (GBM), a grade IV astrocytoma as defined by the World Health Organization (WHO) criteria, is most common primary central nervous system tumor in adults. After treatment with current standard of care consisting surgical resection, concurrent temozolomide (TMZ), and radiation, median survival only 15 months. The limited less-effective options for these highly aggressive GBMs call development new techniques improvement existing technologies. Nanotechnology has shown...
Gallic acid, known for its biological activity contributing to human health, including antioxidant, anti-inflammatory, anticancer, and antimutagenic properties, was the focus of this study. The solubility gallic acid experimentally measured in pure mixed solvents water, ethanol, acetic predicted using COSMO-SAC model Hansen parameter. parameter method a higher water than solvent, it maximum at 80% content, showing different results from experimental data trends. However, molar volume...
Chlorogenic acid, which is extracted from a wide range of natural sources, attracting the attention many researchers in pharmaceutical and biomedical fields due to its various positive effects, such as anti-inflammatory antibacterial properties. Considering effects economics solvent toxicity, water, ethanol, their mixtures were selected solvents for extracting chlorogenic acid at temperatures (298~318 K) over whole concentrations. The solubility increased with temperature regardless...
Chemotherapy for intracranial gliomas is hampered by limited delivery of therapeutic agents through the blood brain barrier (BBB). An optimal agent tumors would selectively cross BBB, accumulates in tumor tissue and be activated from an innocuous prodrug within tumor. Here we show tumor-targeted efficacy a nanometer-sized (nanoprodrug) camptothecin (CPT) to treat experimental glioblastoma multiforme (GBM). The CPT nanoprodrug was prepared using spontaneous nanoemulsification biodegradable,...
Although mechanical properties of concrete under uniaxial compression are important to design structure, current codes or other empirical equations have clear limitation on the prediction properties. Various types fiber-reinforced reactive powder matrix were tested for making more usable and accurate estimation ultra high strength concrete. Investigated has compressive ranged from 30 MPa 200 MPa. Ultra was made by means Preventing brittle failure this type matrix, steel fibers used. The...
In this work, we investigated the prediction of solubility (x d ) drug molecules in single‐ and mixed‐ionic liquid (IL) solutions using COSMO‐SAC activity coefficient model. particular, effect dissociation IL on is examined. The accuracy found to be 91% x (root‐mean‐square deviation ln 0.65) for a total 442 data points with ranging from 0.93 2.84 × 10 −4 (mole fraction) temperature 248.9 488.3 K. not sensitive treatment calculations. method used determine paracetamol 2624 single made...
Traumatic brain injury (TBI) is an enormous public health problem, with 1.7 million new cases of TBI recorded annually by the Centers for Disease Control. However, has proven to be extremely challenging condition treat. Here, we apply a nanoprodrug strategy in mouse model TBI. The novel contains derivative nonsteroidal anti-inflammatory drug (NSAID) ibuprofen emulsion antioxidant α-tocopherol. derivative, Ibu2TEG, tetra ethylene glycol (TEG) spacer consisting biodegradable ester bonds. bonds...
Many unique properties of ionic liquids (ILs) are closely related to the extent dissociation (α) in solution. However, most existing models for ILs assume either full or nondissociation regardless mixture compositions. In this work, (CA = C+ + A–) is described as a chemical reaction. Together with predictive COSMO-SAC model, constant can be determined based on value α pure state. Our results show that predicted composition dependence good agreement experiment over entire concentration range....
In this work, a predictive method is applied to determine the vapor–liquid-hydrate three-phase equilibrium condition of methane hydrate in presence ionic liquids and other additives. The Peng–Robinson–Stryjek–Vera Equation State (PRSV EOS) incorporated with COSMO-SAC activity coefficient model through first order modified Huron–Vidal (MHV1) mixing rule used evaluate fugacities vapor liquid phases. A van der Waals Platteeuw describe phase. absolute average relative deviation predicted...