A5067828195- Inflammatory mediators and NSAID effects
- Protein Kinase Regulation and GTPase Signaling
- Peptidase Inhibition and Analysis
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Ubiquitin and proteasome pathways
- Cell Adhesion Molecules Research
- Peroxisome Proliferator-Activated Receptors
- Venomous Animal Envenomation and Studies
- Fatty Acid Research and Health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Cell Function and Interaction
- Eicosanoids and Hypertension Pharmacology
- Cancer-related Molecular Pathways
- Protease and Inhibitor Mechanisms
- Autophagy in Disease and Therapy
- Healthcare Decision-Making and Restraints
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Asthma and respiratory diseases
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Metabolism and Genetic Disorders
- Immune cells in cancer
- Chemokine receptors and signaling
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Corteva (United States)
2022-2024
Biolog (United States)
2024
Jacksonville College
2023
Mayo Clinic in Florida
2023
WinnMed
2023
Rapt Therapeutics (United States)
2019-2022
APT Therapeutics (United States)
2019-2022
Salesforce (United States)
2022
Glasgow Caledonian University
1995-2020
Ontario Shores Centre for Mental Health Sciences
2016-2020
TRAIL is a member of the tumor necrosis factor (TNF) family cytokines which induces apoptotic cell death in variety lines. It mediates its effects through one two receptors, DR4 and DR5, are members TNF receptor family, whose cytoplasmic regions contain domains. In addition, also binds to 3 "decoy" DcR2, with truncated domain, DcR1, glycosylphosphatidylinositol-anchored receptor, OPG secreted protein known bind another RANKL. However, although apoptosis depends on expression or both domain...
Marine natural products provide a rich source of chemical diversity that can be used to design and develop new, potentially useful therapeutic agents. We report here scytonemin, pigment isolated from cyanobacteria, is the first described small molecule inhibitor human <i>polo</i>-like kinase, serine/threonine kinase plays an integral role in regulating G<sub>2</sub>/M transition cell cycle. Scytonemin inhibited<i>polo</i>-like 1 activity concentration-dependent manner with IC<sub>50</sub> 2...
Background Checkpoint inhibitors (CPIs) such as anti-PD(L)-1 and anti-CTLA-4 antibodies have resulted in unprecedented rates of antitumor responses extension survival patients with a variety cancers. But some fail to respond or initially but later relapse they develop resistance immune therapy. One the tumor-extrinsic mechanisms for therapy is accumulation regulatory T cells (T reg ) tumors. In preclinical clinical studies, it has been suggested that tumor trafficking mediated by CC...
We compared the childhood experiences of criminal psychopaths with those nonpsychopaths, to examine whether differences in either type or intensity adverse experience could be identified. One hundred and five prisoners, 50 psychopaths, 55 nonpsychopaths were assessed Psychopathy Checklist-Revised (PCL-R) Childhood Experience Care Abuse (CECA) semistructured interviews. Both assessment measures have been demonstrated reliable valid instruments. File information from both adult child services...
Interleukin 1β (IL-1β) up-regulates human rheumatoid synovial fibroblast (RSF) 85-kDa phospholipase A2 (PLA2) and mitogen-inducible cyclooxygenase (COX) II. Promoter regions for these genes contain a motif that closely resembles the "classic" NFκB consensus site. Immunoblot analysis identified NFκB1 (p50), RelA (p65), c-Rel in RSF. Upon IL-1β-stimulation, p65 but not p50 protein levels were reduced suggesting nuclear translocation. IL-1β-induced RSF extracts contained p65-containing complex,...
Abstract Much evidence implicates IL-8 as a major mediator of inflammation and joint destruction in rheumatoid arthritis. The effects its related ligands are mediated via two receptors, CXCR1 CXCR2. In the present study, we demonstrate that potent selective nonpeptide antagonist human CXCR2 potently inhibits 125I-labeled binding to, IL-8-induced calcium mobilization by, rabbit (IC50 = 40.5 7.7 nM, respectively), but not &gt;1000 2200 respectively). These data suggest is an appropriate...
This study investigated the role of secretory PLA2 (sPLA2) in arachidonic acid (AA) release and lipid mediator generation mouse bone marrow-derived mast cells. Initial studies indicated that cells contain multiple activities secreted activity upon Ag stimulation. The is blocked by DTT a group II PLA2-neutralizing Ab. Mast incubated with groups I or selectively polyunsaturated fatty acids, such as AA, into supernatant fluids. bulk AA released sPLA2 derived from phosphatidylethanolamine. acids...
Abstract Semipurified diets containing ratios of α‐linolenic acid (18∶3ω3) to linoleic (18∶2ω6) 1/32, 1/7, 1/1, and 3.5/1 in the form corn oil, soybean soybean/linseed oil mix linseed were fed rats for 2 months. The first 3 another group 4 months a through second generation. Fatty analysis liver spleen ethanolamine glycerophosphatide revealed that, as level 18∶3ω3 diet increased, elongated, desaturated metabolites ω6 series decreased ω3 increased. Noteworthy was depression amount precursor...
Studies were conducted to characterize a human monocyte model where the role of 85-kDa phospholipase A2 (PLA2) in prostanoid formation could be evaluated. The presence an immunologically related PLA2 and type II 14-kDa was demonstrated monocytes their roles examined lipopolysaccharide (LPS)-induced prostaglandin E2 (PGE2) formation. Exposure LPS over 18 h resulted up-regulation mitogen-inducible cyclooxygenase-2 accompanied by production release but not leukotriene C4. This coincided with...
The contribution to genetic diversity of genomic segmental copy number variations (CNVs) is less well understood than that single-nucleotide polymorphisms (SNPs). While frequent SNPs, CNVs have greater potential affect phenotype. In this study, we performed the most comprehensive survey date in mice, analyzing genomes 42 Mouse Phenome Consortium priority strains. This microarray comparative hybridization (CGH)-based analysis has identified 2094 putative CNVs, with an average 10 Mb DNA 51...
Recovery-orientated care is becoming generally accepted as the best practice, and continued development in ways it practiced necessary to ensure improvement of ongoing care. Forensic patients often experience double stigmatization (the dual stigma mental illness offending behaviour) during admission hospital may lose touch with their community supports. While working through personal recovery, develop therapeutic relationships multidisciplinary team members. When positive, these can enhance...
Activation of lymphocytes induces blastogenesis and cell division which is accompanied by membrane lipid metabolism such as increased fatty acid turnover. To date little known about the enzymatic mechanism(s) regulating this process. Release acids arachidonic requiressn-2-deacylation catalyzed a class enzymes phospholipases A2 (PLA2, EC3.1.1.4). Herein, we confirm that human peripheral blood B or T (PBL) do not possess measurable levels 85-kDa PLA2 assessed Western immunoblot. Low 14-kDa...
Recent evidence suggests that arachidonic acid (AA) may be involved in regulating cellular proliferation. The predominant mechanism of AA release from phospholipids is via phospholipase A2 (PLA2) hydrolysis. purpose this study was to examine the roles distinct 14-kDa and 85-kDa PLA2 enzymes human coronary artery vascular smooth muscle cell (hCAVSMC) Cultured hCAVSMCs proliferate presence growth medium with a typical doubling time 30–40 h, grow at slower proliferative rate upon reaching...
Background The global gene expression profiles of adult and fetal murine prostate stem cells were determined to define common unique regulators whose misexpression might play a role in the development cancer. Methodology/Principal Findings A distinctive core transcriptional both primitive was identified as well molecules that are exclusive each population. Elements include Wnt, Shh other pathways organs, signatures aryl-hydrocarbon receptor, up-regulation components aldehyde...