A5056177817- Ultrasound and Hyperthermia Applications
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Angiogenesis and VEGF in Cancer
- Breast Cancer Treatment Studies
- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- Photoacoustic and Ultrasonic Imaging
- Advanced Radiotherapy Techniques
- Ultrasound Imaging and Elastography
- Radiation Detection and Scintillator Technologies
- Hepatocellular Carcinoma Treatment and Prognosis
- Nanoplatforms for cancer theranostics
- Fluid Dynamics and Turbulent Flows
- Breast Lesions and Carcinomas
- Renal cell carcinoma treatment
- Photodynamic Therapy Research Studies
- Cardiovascular Health and Disease Prevention
- Rheology and Fluid Dynamics Studies
- Glioma Diagnosis and Treatment
- Breast Implant and Reconstruction
- 3D Shape Modeling and Analysis
- Blood properties and coagulation
- Digital Imaging in Medicine
Institut Gustave Roussy
2014-2024
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2020-2024
Centre National de la Recherche Scientifique
2007-2024
Inserm
2017-2024
Université Paris-Saclay
2007-2024
CEA Paris-Saclay
2020-2024
Laboratoire d’Imagerie Biomédicale
2021-2022
Institut d'Imagerie Biomédicale
2008-2021
Imagerie par Résonance Magnétique Médicale et Multi-Modalités
2012-2021
Fluides, Automatique et Systèmes Thermiques
2020
Hyperprogressive disease (HPD) is an aggressive pattern of progression reported for patients treated with programmed cell death 1 (PD-1)/programmed ligand (PD-L1) inhibitors as a single agent in several studies. However, the use different definitions HPD introduces risk describing tumoral behaviors.To assess accuracy each definition to identify frequency and association poorer outcomes immune-checkpoint inhibitor (ICI) treatment advanced non-small lung cancer (NSCLC) provide optimized...
Background The development and clinical adoption of quantitative imaging biomarkers (radiomics) has established the need for identification parameters altering radiomics reproducibility. aim this study was to assess impact magnetic field strength on resonance (MRI) features in neuroradiology practice. Methods T1 3D SPGR sequence acquired two phantoms 10 healthy volunteers with MR devices from same manufacturer using different fields (1.5 3T). Phantoms varied terms gadolinium concentrations...
The purposes of this study were to assess the reliability parametric maps from dynamic contrast-enhanced ultrasound (DCE-US) reflect heterogeneous distribution intratumoral vascularization and predict tissue features linked vasculature. This was designed compare DCE-US with histologic vascularity measurements.Dynamic performed on 17 melanoma-bearing nude mice after a 0.1-mL bolus injection SonoVue (Bracco SPA, Milan, Italy). developed raw linear data extract pixelwise 2 semiquantitative...
Texture analysis is an emerging tool in the field of medical imaging analysis. However, many issues have been raised terms its use assessing patient images and it crucial to harmonize standardize this new measurement tool. This study was designed evaluate reliability texture indices CT on a phantom including reproducibility study, assess discriminatory capacity potentially relevant determine their redundancy.For analysis, eight identical acquisitions were performed one homogeneous insert two...
The purpose of this study was to investigate the impact arterial input on perfusion parameters measured using dynamic contrast-enhanced sonography combined with a deconvolution method after bolus injections contrast agent.The in vitro experiments were conducted custom-made setup consisting pumping fluid through phantom made 3 intertwined silicone pipes, mimicking complex structure akin that vessels tumor, their feeding pipe, input. In vivo experiments, B16F10 melanoma cells xenografted 5...
The aim of this study was to compare the effectiveness a hand-held preoperative compact imager (POCI) camera with conventional lymphoscintigraphy using γ-camera for sentinel lymph node (SLN) detection in breast cancer. <b>Methods:</b> main objective demonstrate noninferiority POCI relative and number SLNs detected by 2 imaging devices. Our study, clinical prospective, double-blind, planned include 200 patients early cancer started January 2006. A standard SLN protocol (4 periareolar...
Objectives Dynamic contrast-enhanced (DCE) ultrasonography (US) is a functional imaging technique enabling quantitative assessment of solid tumor perfusion in metastatic patients treated with antiangiogenic therapies. The objective this prospective single-center study was to evaluate real-life conditions (in routine clinical practice) the intrapatient variability and reproducibility DCE-US parameters. Materials Methods Each patient provided written informed consent had 2 examinations...
Recent treatment developments for metastatic renal cell carcinoma offer combinations of immunotherapies or immunotherapy associated with tyrosine kinase inhibitors (TKI). There is currently no argument to choose one solution another. Easy-to-use markers assess longitudinal responses TKI are necessary determine when switch immunotherapies. These new will enable an earlier adaptation therapeutic strategy in order prevent tumor development, unnecessary toxicity and financial costs. This study...
Surgery is considered as the primary therapeutic procedure for gliomas and several recent clinical studies have shown that total tumor resection directly associated with longer survival when compared to subtotal resection. In order refine in boundaries of gliomas, we are developing an intraoperative probe specifically dedicated localization residual labeled positron emitters. The designed be compact electrically safe coupled excision tool leading simultaneous detection removal tissues. It...
The precise delineation and excision of brain tumor extent allows to improve survival outcome quality life surgically treated patients. In order refine the resection gliomas, we are developing a novel intraoperative probe specifically dedicated localization residual after bulk has been excised. probe, built around clear plastic scintillating fibers, was designed detect positrons emitted from radiolabeled tissue in discriminate more neoplastic normal tissues. also be directly coupled tool...
Tumor microvascularization is a biomarker of response to antiangiogenic treatments and accurately assessed by ultrasound imaging. Imaging modes used visualize slow flows include Power Doppler imaging, dynamic contrast-enhanced ultrasonography, more recently, microvascular Doppler. Flow phantoms are evaluate the performance imaging techniques, but they do not have steady flow sufficiently small channels. We report novel device for robust stable microflow measurements study...
We propose a hemodynamic reduced-order model bridging macroscopic and mesoscopic blood flow circulation scales from arteries to capillaries. In silico tree-like vascular geometries, mathematically described by graphs, are synthetically generated means of stochastic growth algorithms constrained statistical morphological topological principles. Scale-specific pruning gradation the tree is then proposed in order fit computational budget requirement. Different compliant structural models with...
Dynamic contrast-enhanced ultrasonography is a recent functional dynamic imaging technique that allows evaluation of the efficacy anti-angiogenic treatments by quantifying changes in specific parameters tumor vasculature. Preclinical and clinical experimental studies now reveal existence sources variability quantitative methods. In order to study reliability quantification methods (both semi-quantitative quantitative), we have developed first numerical model blood flow contrast agents...
The present work aims a new medical probe for surgeons devoted to brain cancers, in particular glioblastoma multiforme. Within the last years, our group has started development of intra-operative beta imaging probe. More recently, we took an alternative approach same application: fluorescence In both cases purpose is differentiate normal from tumor tissue. first step, developed set-ups capable measure autofluorescence. They are based on dedicated epi-fluorescence design and specific fiber...
This study presents an investigation of innovative microfluidic flow separator using both numerical and experimental approaches to calibrate contrast-enhanced ultrasound scanners. Numerical simulations were conducted Lagrangian particles tracking passive scalar transport methodologies the OpenFOAM software. The validation confirmed accuracy simulations, particularly at imposed total pressure
"Numerical modelling of the flow ultrasound contrast agents in tumour microvasculature." Computer Methods Biomechanics and Biomedical Engineering, 17(sup1), pp. 18–19Keywords:: CFDmicrocirculationDCE-UStumour
Abstract Background The DCE‐US (Dynamic Contrast‐Enhanced Ultrasonography) imaging protocol predicts the vascular modifications compared with Response Evaluation Criteria in Solid Tumors (RECIST) based mainly on morphological changes. A quantitative biomarker has been validated through multi‐centric study for early monitoring of efficiency anti‐angiogenic cancer treatments. In this context, question transposing use to other types ultrasound scanners, probes and settings arisen maintain...
Molecular magnetic resonance imaging targeted to an endothelial integrin involved in neoangiogenesis was compared DCE-US and immunochemistry assess the early response of three different therapeutic agents renal cell carcinoma. Human A498 cells carcinoma subcutaneously inoculated into 24 nude mice. Mice received either phosphate-buffered saline solution, sunitinib, everolimus, or bevacizumab during 4 days. molecular MRI targeting α v β 3 were performed at baseline days after treatment...
Head and neck cancer (HNC) is the sixth most prevalent worldwide. Dynamic contrast-enhanced MRI (DCE-MRI) helps in diagnosis prognosis. Quantitative DCE-MRI requires an arterial input function (AIF), which affects values of pharmacokinetic parameters (PKP).To evaluate influence four individual AIF measurement methods on quantitative (Ktrans , ve kep vp ), for HNC muscle.Prospective.A total 34 patients (23 males, 11 females, age range 24-91) FIELD STRENGTH/SEQUENCE: A 3 T; 3D SPGR gradient...