A5089089207- Venous Thromboembolism Diagnosis and Management
- Rheumatoid Arthritis Research and Therapies
- Biosimilars and Bioanalytical Methods
- Health Systems, Economic Evaluations, Quality of Life
- Lung Cancer Diagnosis and Treatment
- Respiratory viral infections research
- Autoimmune and Inflammatory Disorders Research
- Acute Myocardial Infarction Research
- Biomedical Ethics and Regulation
- Urticaria and Related Conditions
- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Ultrasound in Clinical Applications
- Diagnosis and Treatment of Venous Diseases
- Chronic Lymphocytic Leukemia Research
- Pleural and Pulmonary Diseases
Karolinska Institutet
2020-2025
Karolinska University Hospital
2013-2025
University of Gothenburg
2013
To assess the incidence of venous thromboembolism (VTE) in rheumatoid arthritis (RA) relative to individuals without RA, and investigate relationship between aspects clinical disease activity RA risk VTE.We conducted a nationwide register-based cohort study 2006 through 2018 using Swedish Rheumatology Quality Register linked other national patient registers identify all patients with at least one registered rheumatologist visit during period (n=46 316 patients, 322 601 visits). The Disease...
To assess and compare the incidence of venous thromboembolism (VTE) in patients with rheumatoid arthritis (RA) treated Janus kinase inhibitors (JAKi), tumour necrosis factor (TNFi) or other biological disease modifying antirheumatic drugs (bDMARDs). For contextualisation, to VTE incidences Swedish general population RA source population.We performed a nationwide register-based, active comparator, new user design cohort study Sweden from 2010 2021. The Rheumatology Quality Register was linked...
To investigate rates of key safety outcomes in patients with rheumatoid arthritis (RA) initiating biologic/targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) and reference cohorts, presented over time since the market entry each b/tsDMARD class calendar period at treatment start. This was a nationwide register-based cohort study conducted from 2006 to 2022. From Swedish Rheumatology Quality Register national registers, we identified initiators b/tsDMARDs (n = 33,550...
Streptococcus pneumoniae infection is a serious problem worldwide and the case fatality rate remains high. The aim of this study was to analyze distribution pneumococcal serotypes causing invasive disease (IPD), survey potential coverage present future vaccines, investigate differences between groups with regard manifestation, rate, age, other risk factors. Isolates from 244 consecutive patients IPD were collected at Christian Medical College, Vellore, India January 2007 June 2011, clinical...
To assess the validity of venous thromboembolism (VTE) diagnoses registered in Swedish National Patient Register (NPR) patients with rheumatoid arthritis (RA).We performed a validation study using manual chart reviews to validate ICD-10 codes for VTE from NPR. We took random sample 269 events at hospitals Region Stockholm 2009 2018 RA.Medical records all were available review. Overall, positive predictive value (PPV) diagnosis was 95%. For incident events, PPV 87% and ranged 80% 98% across...
Background: Patients with rheumatoid arthritis (RA) are at increased risk for venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE) (1). Several established factors of VTE, such as age, immobilization comorbid conditions, occur more often patients RA (2). In addition, inflammation may in itself also increase VTE by upregulating procoagolatory causing endothelial damage (3). Recent reports indicate an treated JAK-inhibitors (4), pointing to the need...
<p dir="ltr">Individuals with rheumatoid arthritis (RA) are at around 50-100% increased risk of venous thromboembolism (VTE). In 2019, signals emerged suggesting an VTE in RA patients treated JAK inhibitors (JAKi), a new and highly efficacious class disease- modifying antirheumatic drug (DMARD). this thesis, we aimed to further disentangle the associations between RA, its treatment, series observational studies. We used data from Swedish rheumatology quality register other national...
<p dir="ltr">Individuals with rheumatoid arthritis (RA) are at around 50-100% increased risk of venous thromboembolism (VTE). In 2019, signals emerged suggesting an VTE in RA patients treated JAK inhibitors (JAKi), a new and highly efficacious class disease- modifying antirheumatic drug (DMARD). this thesis, we aimed to further disentangle the associations between RA, its treatment, series observational studies. We used data from Swedish rheumatology quality register other national...
We report a case of chronic empyema in 63-year-old man with history asbestos exposure and alcohol overconsumption. In 2009, he presented dyspnoea, exudative pleurisy on the right side no symptoms infection or malignancy. 2013, patient increased dyspnoea massive had evolved. Culture pleural fluid was positive for Escherichia coli anaerobic bacteria, treated antibiotics, chest drainage as well surgical evacuation. After surgery, lung failed to expand, growth opportunistic bacteria rising C...