A5051185180- Pneumonia and Respiratory Infections
- Vasculitis and related conditions
- Respiratory viral infections research
- HIV/AIDS Research and Interventions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- T-cell and B-cell Immunology
- Streptococcal Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Sepsis Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- HIV, Drug Use, Sexual Risk
- Cytomegalovirus and herpesvirus research
- Systemic Lupus Erythematosus Research
- Adolescent Sexual and Reproductive Health
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Dermatological and Skeletal Disorders
- Clinical Nutrition and Gastroenterology
- Otitis Media and Relapsing Polychondritis
- Herpesvirus Infections and Treatments
- Pancreatic and Hepatic Oncology Research
- Atherosclerosis and Cardiovascular Diseases
University of Gothenburg
2015-2025
Sahlgrenska University Hospital
2009-2025
Oslo University Hospital
2025
Region Västra Götaland
2019-2024
Skaraborg Hospital
2006-2020
Institute for Biomedicine
2010-2020
Göteborgs Stads
1988-2020
Skåne University Hospital
2011-2019
Infectious Diseases Institute
2010-2017
Lund University
1989-2016
Background. @nbsp; Cerebrovascular complications (CVCs) have remained a major therapeutic and prognostic challenge associated with infective endocarditis, definite risk factors not been fully elucidated. This prospective study was designed to the evaluate total incidence of CVC endocarditis factors. Methods. During 2 periods, from June 1998 through April 2001 September 2002 January 2005, patients were prospectively enrolled in regardless neurological symptoms. Study underwent examinations...
Background Early recognition is a key factor to achieve improved outcomes for septic patients. Combinations of biomarkers, as opposed single ones, may improve timely diagnosis and survival. We investigated the performance characteristics sepsis alone in combination, verified bacterial using Sepsis-2 Sepsis-3 criteria, respectively. Methods Procalcitonin (PCT), neutrophil-lymphocyte count ratio (NLCR), C-reactive protein (CRP), lactate were determined total 1,572 episodes adult patients...
AbstractVertebral osteomyelitis (VO) is a rare condition and the diagnosis often overlooked initially. Delay in may result vertebral destruction or perforation of spinal canal. We suggest diagnostic criteria order to simplify classification VO. Medical records 58 patients with VO from Go¨teborg during years 1990?95 were studied retrospectively. The incidence, clinical presentation, microbiology treatment evaluated. median age at time admission was 59 y (range 13?83 y) male:female ratio 1.6 :...
Incidence, manifestations and case-fatality rate (CFR) of invasive pneumococcal disease (IPD) vary with age comorbidities. New vaccines, changing distribution, prolonged survival among immunocompromised patients improved sepsis management have created a need for an update basic facts to inform vaccine recommendations.Age, gender comorbidities were related death 2977 consecutive IPD in Swedish region 1.5 million inhabitants during 13 years before introduction conjugate vaccines (PCV) the...
From the Unit of Infection Prevention and Control, Department Clinical Microbiology, Sahlgrenska University Hospital, Gothenburg, Sweden (RA, IQ), Infectious Diseases, Institute Biomedicine, Academy, Gothenburg University, (RA), Prevention, Oslo Oslo, Norway (EL), Region Stockholm (AT), Medicine Solna, Karolinska Institutet, (AT) Correspondence to Rune Andersson, Guldhedsgatan 10a, SE-40234 Sweden. Tel: +46 706441238; e-mail: [email protected]
Familial amyloidotic polyneuropathy (FAP) in Swedish patients is associated with the same transthyretin mutation (TTRMet30) as Portuguese, Japanese, Brazilian and Majorcan patients. Yet, age of onset FAP much later Sweden than other populations. We have studied 239 cases from northern Sweden, their geographical distribution, differences onset, estimated prevalence incidence rates. Cases families concentrate mainly two areas, around towns Skellefteå Piteå. Mean was found to be Piteå (58.8 ±...
Ninety patients with giant cell arteritis were followed up 9-16 years (median 11.3 years) after diagnosis. The mean duration of corticosteroid therapy was 5.8 (range 0-12.8 years). Together, the had received corticosteroids for 492 patient-years. Five diagnosis, 43% on therapy. After 9 years, 15 60 surviving (25%) still being treated 1.25-10 mg prednisolone daily dose 5 mg). relapse rate about 50%, regardless time when an attempt to withdraw treatment made. Forty-six per cent relapses...
We conducted a prospective study of all cases invasive Staphylococcus aureus infections (ISA) in the catchment area Skaraborg Hospital (population 255,109) western Sweden from March 2003 to February 2005. The annual incidence was 33.9 cases/100,000 population. Of these, 49% were classified as community-acquired, 32% nosocomial and 19% health care-associated. mean age 65 y. registered children (age < or = 18 y) 13 episodes. most common predisposing illnesses/conditions persons undergoing...
Abstract. An account, mainly clinical, is given of 18 cases hereditary amyloidosis with polyneuropathy. Common to all were progressive peripheral sensory‐motor nervous disturbances starting in the legs. Gastrointestinal dysfunction malabsorption occurred frequently, as did various symptoms autonomic disturbances. Characteristic opacities corpus vitreum found. Various ECG changes occurred, indicative amyloidotic heart involvement, which also may have contributed congestive cardiac failure...
Abstract Background Fast-track (FT) programmes are multimodal, evidence-based approaches to optimize patient outcome after surgery. The aim of this study was evaluate the safety, clinical and patients' experience a FT programme pancreaticoduodenectomy (PD) in high-volume institution Sweden. Methods Consecutive patients undergoing PD were studied before implementation programme. changes included earlier mobilization, standardized removal nasogastric tube drain, start oral intake. Patient...
Culture-negative infective endocarditis (CNE) is a diagnostic problem in spite of improved echocardiographic and blood culturing techniques. We conducted the present study to estimate proportion CNE patients with endocarditis, investigate data regarding risk factors, evaluate Duke modified Beth Israel criteria CNE. evaluated 820 consecutive suspected episodes adults at Departments Infectious Diseases Göteborg Borås, Sweden (1984–1996). All were diagnosed treated according protocol; 487...
Abstract The expression of T‐cell surface antigens was investigated in the cerebrospinal fluid (CSF) and peripheral blood 11 patients with multiple sclerosis, 6 aseptic meningitis, 16 healthy subjects. A panel monoclonal antibodies to adhesion activation proteins used combination an anti‐CD3 antibody dual‐color flow cytometry. problem low cell numbers CSF from normal individuals overcome by use a modified staining procedure microtiter plates, enabling analysis as few 5,000 cells. majority T...
Pacemaker endocarditis is a rare but serious complication. Few studies addressing its treatment have been published. Clinical characteristics and outcome were retrospectively studied in 38 patients with 44 episodes of pacemaker infective (PMIE) Göteborg, during 1984–2001. The male/female ratio was 27/17 the mean age 69 y. Transthoracic echocardiography (TTE) showed vegetation 4/22 (18%) transoesophageal (TEE) 22/33 (67%). Staphylococci isolated 66% blood cultures. system (PS) removed 28 18...
Various Gram-positive bacteria express different types of IgG-binding receptors, each which displaying certain unique binding properties. To evaluate specificity and avidity aspects the differential pattern, a set competitive assays was employed, by using staphylococcal protein A (SPA), streptococcal G (SPG), chimeric AG. These receptors were analyzed, in reciprocal fashion, for inhibition to selected panel polyclonal monoclonal Ig. Results study reveal that majority determinants on human...
T lymphocytes provide a major line of defence against many protozoan parasites. The aim this work was to determine the role T‐cell helper/inducer subset (T h/i) in resistance Trypanosoma cruzi murine model. imponatance natural killer (NK) cells parasite also evaluated. BALB/c and C57BL/6 mice were injected with either monoclonal antibodies L3T4, Thy 1.2, NK1.1, or polyclonal rabbit antiserum NK (anti‐asialo GM‐1). effect vivo administration these tested separate functional assays. Alter...
Cytomegalovirus (CMV) is associated with an increased risk of cardiac allograft vasculopathy (CAV), the major limiting factor for long-term survival after heart transplantation (HTx). The purpose this study was to evaluate impact CMV infection during follow-up HTx. A retrospective, single-centre analyzed 226 HTx recipients (mean age 45 ± 13 years, 78 % men) who underwent between January 1988 and December 2000. incidence factors first year were studied. Risk CAV included in analyses CAV-free...
Background: Apoptosis is a critical step responsible for maintaining the cellular balance between proliferation and death controlling tumorigenesis. Although an increase in intestinal apoptotic cells has been considered to be associated with pathogenesis of gastrointestinal injury, little understood concerning role apoptosis development barrier dysfunction. Methods: induced by intraperitoneal injection doxorubicin rats was evaluated transmission electron microscopy TUNEL histochemistry...
Extended genealogical studies were performed on the heredity patterns in Swedish patients with familial amyloidotic polyneuropathy (FAP) using historical archives. The population studied included 239 patients: 109 linked to five large pedigrees and 80 belonged 30 smaller or nuclear families. In remaining 50 cases, no links found. Differences mean ages of onset between different found, although a considerable variation within was also present. There tendency for later among older generations...