A5089562977- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
- Schizophrenia research and treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Epigenetics and DNA Methylation
- COVID-19 Clinical Research Studies
- Vitamin D Research Studies
- Bipolar Disorder and Treatment
- Neurological and metabolic disorders
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Pancreatic function and diabetes
- Pituitary Gland Disorders and Treatments
- Gestational Diabetes Research and Management
- Thyroid Disorders and Treatments
- Magnesium in Health and Disease
- Lipid metabolism and disorders
- Bariatric Surgery and Outcomes
- Regulation of Appetite and Obesity
- Thyroid Cancer Diagnosis and Treatment
Wayne State University
2015-2024
Detroit Medical Center
2020-2022
Eugene Applebaum College of Pharmacy and Health Sciences
2018-2019
Hamad Medical Corporation
2014
Weatherford College
2011
Diabetes Australia
2010
University of Colorado Health
2006
Addis Ababa University
1992-2003
Tikur Anbessa Hospital
1997
Lipasin (also known as C19ORF80, RIFL, ANGPTL8 and betatrophin) is a newly discovered circulating factor that regulates lipid metabolism promotes pancreatic β-cell proliferation. Whether levels of lipasin in humans are altered a) type 2 diabetes; b) obesity c) the postprandial state, however, unknown. The current study aimed to compare serum those who were non-diabetic (N = 15) or diabetic (BMI- age-matched; N 14); lean obese 53 totally) fasting hours following defined meal 12). Serum...
Insulin receptor substrate 1 (IRS1) is a key mediator of insulin signal transduction. Perturbations involving IRS1 complexes may lead to the development resistance and type 2 diabetes (T2D). Surprisingly little known about proteins that interact with in humans under health disease conditions. We used proteomic approach assess interaction partners skeletal muscle from lean healthy control subjects (LCs), obese insulin-resistant nondiabetic (OCs), participants T2D before after infusion....
Insulin resistance, which plays a central role in the pathogenesis of type 2 diabetes (T2D), is an early indicator that heralds occurrence T2D. It imperative to understand metabolic changes occur at cellular level stages insulin resistance. The objective this study was determine pattern circulating lactate levels during oral glucose tolerance test (OGTT) and hyperinsulinemic euglycemic clamp (HIEC) normal nondiabetic subjects. Lactate glycerol were determined every 30 minutes OGTT HIEC on 22...
Metabolic syndrome (MetS) is highly prevalent worldwide, and its individual components obesity, diabetes, hypertension have been identified as risk factors to develop severe coronavirus disease 2019 (COVID-19); however, data on MetS clinical outcomes in COVID-19 are scarce. This study aims determine association between outcomes, that is, mortality, need for mechanical ventilation, intensive care unit (ICU) requirement among patients with COVID-19.
COVID-19 morbidity and mortality are increased in type 1 diabetes (T1D), but few data focus on age-based outcomes.
Purpose: In the development of diabetic retinopathy, retinal mitochondria become dysfunctional, and mitochondrial DNA (mtDNA) is damaged. Because retinopathy a progressive disease, circulating glucose levels are high in diabetes, our aim was to investigate if peripheral blood mtDNA damage can serve as potential biomarker retinopathy. Methods: Peripheral investigated by extended-length PCR rats mice, for 10 12 months (streptozotocin-induced, type 1 model), 12- 40-week-old Zucker fatty (ZDF,...
Patient-derived progenitor cell (PC) dysfunction is severely impaired in diabetes, but the molecular triggers that contribute to mechanisms of PC are not fully understood. Methylglyoxal (MGO) one highly reactive dicarbonyl species formed during hyperglycemia. We hypothesized MGO scavenger glyoxalase 1 (GLO1) reverses bone marrow-derived (BMPC) through augmenting activity an important endoplasmic reticulum stress sensor, inositol-requiring enzyme 1α (IRE1α), resulting improved diabetic wound...
Purpose: Progression of diabetic retinopathy is related to the duration and severity hyperglycemia, after 25 years diabetes, 90% patients show some signs retinopathy. Despite initiation many retinal molecular/biochemical abnormalities, including mitochondrial damage epigenetic modifications, disease remains asympotomatic in initial stages. Our goal examine utility DNA methylation as a possible biomarker Methods: Genomic (gDNA) was isolated from buffy coat, blood with proliferative (PDR) or...
Abstract Pseudomonas aeruginosa keratitis is characterized by severe corneal ulceration and may lead to blindness if not treated properly in a timely manner. Although the roles of IL-1 subfamily cytokines are well established, as newly discovered subfamily, IL-36 cytokine regulation, immunological relevance, relation with host defense remain largely unknown. In this study, we showed that P. infection induces expression IL-36α IL-36γ, IL-1β secreted IL-1Ra (sIL-1Ra), but IL-36Ra....
We systematically inspected insulin injection sites in 100 insulin-requiring patients attending the Diabetic Clinic of Tikur Anbassa Hospital (TAH) order to identify local complications related incorrect technique: were found 53 cases: skin hyperpigmentation and/or indurations 30 patients; and fat atrophy or hypertrophy 31 patients. Illiteracy was significantly more common among those with (18/53 versus 6/47, χ 2 5.03, P < 0.05). Mean fasting blood glucose on day inspection higher (14.9...
Peak exercise oxygen consumption (peak VO 2 ), as measured by expired gas analysis, is an accurate, reproducible and reliable method for determining capacity. In this study, a cohort of 468 patients with type diabetes underwent graded testing to measure peak at baseline; the was followed five years occurrence cardiovascular disease (CVD) events. Patients who developed CVD events during five-year follow-up period were found have significantly lower baseline , compared those did not (p=0.02)....
Study Objective Atypical antipsychotics cause insulin resistance that leads to an increased risk of diabetes mellitus and cardiovascular disease. Skeletal muscle is the primary tissue for uptake glucose, its dysfunction considered one defects in development resistance. Protein kinase B ( AKT ) plays important role overall skeletal health glucose into muscle. The objective this study was measure isoform–specific gene methylation differences patients with bipolar disorder treated atypical...
Antipsychotics are associated with severe metabolic side effects including insulin resistance; however, the mechanisms underlying this effect not fully understood. The skeletal muscle plays a critical role in insulin-stimulated glucose uptake, and changes DNA methylation by antipsychotics may play development of resistance. A double-blind, placebo-controlled trial olanzapine was performed healthy volunteers. Twelve volunteers were randomized to receive 10 mg/day for 7 days. Participants...
Abstract Disclosure: S. Makadsi: None. T. Altaweel: B. Seyoum: A. Garg: Introduction: Anaplastic Thyroid Carcinoma (ATC) is a very rare and aggressive form of thyroid cancer. It mostly occurs in people over 60 years age, has unexpected local distant metastases with short average survival rate 6 months approximately 1 5 alive after 12 months. Though there are long term survivors, here we presenting an unfortunate rapid case highly anaplastic carcinoma. Case Presentation: A 63-year-old female...
This study profiles ceramides extracted from visceral and subcutaneous adipose tissue of human subjects by liquid chromatography-mass spectrometry to determine a correlation with status diabetes gender.Samples abdominal wall (n = 36 n 31, respectively) were taken during laparoscopic surgery patients (14 nondiabetic, 22 diabetic prediabetic) undergoing bariatric body mass index (BMI) >35 kg/m2 ≥1 existing comorbidity or BMI ≥40 . Sphingolipids analyzed using spectrometry.After logarithm 2...