A5040454198- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Genomics and Phylogenetic Studies
- Plant Pathogenic Bacteria Studies
- Stroke Rehabilitation and Recovery
- Cardiac Health and Mental Health
- Bacterial Genetics and Biotechnology
- Superconducting Materials and Applications
- Antibiotic Resistance in Bacteria
- Particle accelerators and beam dynamics
- Particle Accelerators and Free-Electron Lasers
- Mycobacterium research and diagnosis
- Microbial Community Ecology and Physiology
- Bacteriophages and microbial interactions
- Telemedicine and Telehealth Implementation
- Microbial Metabolism and Applications
- Bacterial Identification and Susceptibility Testing
- Plant-Microbe Interactions and Immunity
- Radiation Dose and Imaging
- RNA and protein synthesis mechanisms
- Cardiovascular and exercise physiology
- Microbial Natural Products and Biosynthesis
- Digital Radiography and Breast Imaging
- Radiology practices and education
- Phytochemistry and Biological Activities
Juntendo University
2013-2024
Juntendo University Hospital
2024
Vigyan Prasar
2015
Nanyang Technological University
2015
National University of Singapore
2015
Bellingham Technical College
2015
Japan Synchrotron Radiation Research Institute
2003
RIKEN
1988
Staphylococcus haemolyticus is an opportunistic bacterial pathogen that colonizes human skin and remarkable for its highly antibiotic-resistant phenotype. We determined the complete genome sequence of S.haemolyticus to better understand pathogenicity evolutionary relatedness other staphylococcal species. A large proportion open reading frames in genomes S.haemolyticus, aureus, epidermidis were conserved their order on chromosome. identified a region chromosome just downstream origin...
Panton-Valentine leukocidin (PVL) has long been considered a critical toxin in severe Staphylococcus aureus infection. PVL presumably breaches the body's defense system by lysing human polymorphonuclear cells (PMNs). Recently, however, bioactive peptides--phenol-soluble modulins (PSMs)--have proposed as main player lysis of PMNs, rather than PVL. This study aimed to resolve uncertainty concerning cause PMNs using recombinant toxins and PVL-neutralizing monoclonal antibodies. The showed...
By screening cultures of soil bacteria, we re-discovered an old antibiotic (nybomycin) as with a novel feature. Nybomycin is active against quinolone-resistant Staphylococcus aureus strains mutated gyrA genes but not those intact which quinolone antibiotics are effective. Nybomycin-resistant mutant were generated from quinolone-resistant, nybomycin-susceptible, vancomycin-intermediate S. (VISA) strain Mu 50. The mutants, occurring at extremely low rate (<1 × 10(-11)/generation), found to...
We previously reported the first 'reverse antibiotic' (RA), nybomycin (NYB), which showed a unique antimicrobial activity against Staphylococcus aureus strains. NYB specifically suppressed growth of quinolone-resistant S. strains but was not effective quinolone-susceptible Although in 1955, little known about its because it before synthesis quinolone ('old quinolone'), nalidixic acid, 1962. Following our re-discovery NYB, we looked for other RAs among natural substances that act on bacteria....
Background The COVID-19 pandemic has required an increased need for rehabilitation activities applicable to patients with chronic diseases. Telerehabilitation several advantages, including reducing clinic visits by vulnerable infectious Digital platforms are often used assist services in remote settings. Although web portals medical use have existed years, the technology telerehabilitation remains a novel method. Objective This scoping review investigated functional features and theoretical...
Abstract Flavonoids are plant-produced secondary metabolites that found ubiquitously. We have previously reported apigenin, a class of flavonoid, has unique antimicrobial activity against Staphylococcus aureus ( S. ), one the major human pathogens. Apigenin inhibited fluoroquinolone-resistant with DNA gyrase harboring quinolone-resistant S84L mutation but did not inhibit wild-type gyrase. In this study, we describe five flavonoids, quercetin, luteolin, kaempferol, baicalein, and commercially...
We developed a simple, efficient, and cost-effective method, named the re plica p lating t olerance i solation s ystem (REPTIS), to detect antibiotic tolerance potential of bacterial strain. This method can also be used quantify antibiotic-tolerant subpopulation in susceptible population.
Abstract During the exploration of microbial natural resources, two strains Pseudomonas , PS14 T and PS24 were isolated from samples taken Izu Oshima, a volcanic island located 120 km southwest central Tokyo. Phylogenetic analysis based on 16S rRNA gene sequences showed that was most similar to baetica a390 (99.6%) helmanticensis OHA11 (99.5%), qingdaonensis JJ3 (98.8%) lutea OK2 (98.7%). The major fatty acids these C 16:0 17:0 cyclo, summed feature 3 (C 16:1 ω6c and/or ω7c), 8 18:1 ω7c...
The taxonomic classification of Pseudomonas species has been revised and updated several times. This study utilized average nucleotide identity (ANI) digital DNA–DNA hybridization (dDDH) cutoff values 95 70 %, respectively, to re-identify the strains deposited in GenBank as P. aeruginosa , fluorescens putida . Of 264 strains, 259 were correctly identified but remaining five not. All 28 had incorrectly Four these re-identified, including two kilonensis one each brassicacearum 24 could not be...
Heart failure is one of the world's most frequently diagnosed cardiovascular diseases. An important element heart management cardiac rehabilitation, goal which to improve patients' recovery, functional capacity, psychosocial well-being, and health-related quality life. Patients in rehabilitation may lack sufficient motivation or feel that process does not meet their individual needs. One solution these challenges use telerehabilitation. Although telerehabilitation has been available for...
Abstract Although infection with the methicillin-resistant Staphylococcus aureus (MRSA) clone USA300 is extremely rare in Japan, uniquely evolved ΨUSA300 has been reported Japan. An outbreak of a distinct was recently an HIV/AIDS referral hospital Tokyo. The present study investigated evolutionary origin and genetic diversity USA300-related clones causing regional outbreaks among people living HIV (PLWHIV) MRSA isolates collected from PLWHIV center Tokyo were subjected to whole-genome...
The mechanisms underlying bacterial tolerance to antibiotics are unclear. A possible adaptation strategy was explored by exposure of drug-naive methicillin-susceptible Staphylococcus aureus strain FDA209P vancomycin in vitro Strains surviving treatment (vancomycin survivor strains), which appeared after 96 h exposure, were slow-growing derivatives the parent strain. Although MICs for strains within susceptible range, cytokilling effects at 20-fold MIC significantly lower than Whole-genome...
ABSTRACT Large-scale chromosomal inversions (455 to 535 kbp) or deletions (266 320 were found accompany spontaneous loss of beta-lactam resistance during drug-free passage the multiresistant Staphylococcus haemolyticus clinical strain JCSC1435. Identification and sequencing rearranged loci revealed that ISSha 1 S. is responsible for chromosome rearrangements.
We report the complete genome sequence of methicillin-sensitive Staphylococcus aureus (MSSA) strain FDA209P (ATCC 6538P and NCTC 7447).
An aerobic, Gram-stain-negative, rod-shaped bacterial strain, IzPS43_3003 T , was isolated from Izu Oshima, an active volcanic island located 22 km east of the Peninsula, Japan. The sequence its 16S rRNA gene indicated that belongs to Pseudomonas fluorescens lineage, with being most similar vancouverensis DhA-51 (99.79 %). Phylogenetic analysis based on whole genome sequences showed a member jessenii subgroup. average nucleotide identity values and genome-to distances between other type...
Commercially available active video games (AVGs) have recently been used for rehabilitation in some specific patient populations but rarely those with cardiovascular disease (CVD). AVGs are designed to increase motivation continuous play, which could be applicable the long-term cardiac process.The objective of this scoping review was assess effectiveness AVG-induced physical exercise, safety management, and adherence by applying commercially rehabilitation.Four databases (CINAHL, MEDLINE,...
Soil samples from a remote Japanese island (Kozushima) were processed and investigated for organisms exhibiting antimicrobial activity against pathogenic strains. A Pseudomonas strain demonstrating Staphylococcus aureus (S. aureus) was observed, leading to further investigation. Whole-genome sequencing used identify species phylogenetic analysis, followed by in silico molecular analysis. Chemotaxonomic biochemical analyses conducted characterize the further. Genomic analysis identified of...
Soil samples from a remote Japanese island (Kozushima) were processed and investigated for organisms exhibiting antimicrobial activity against pathogenic strains. A Pseudomonas strain demonstrating Staphylococcus aureus (S. aureus) was observed, leading to further investigation. Whole-genome sequencing used identify species phylogenetic analysis, followed by in silico molecular analysis. Chemotaxonomic biochemical analyses conducted characterize the further. Genomic analysis identified of...
Soil samples from a remote Japanese island (Kozushima) were processed and investigated for organisms exhibiting antimicrobial activity against pathogenic strains. A