A5018752755- Venous Thromboembolism Diagnosis and Management
- Immune Cell Function and Interaction
- Peripheral Artery Disease Management
- T-cell and B-cell Immunology
- Sleep and related disorders
- Vasculitis and related conditions
- Diagnosis and Treatment of Venous Diseases
- Mast cells and histamine
- Medical and Biological Sciences
- Cytokine Signaling Pathways and Interactions
- Phagocytosis and Immune Regulation
- Asthma and respiratory diseases
- Circadian rhythm and melatonin
- Clinical practice guidelines implementation
- Kawasaki Disease and Coronary Complications
- Reproductive Physiology in Livestock
- S100 Proteins and Annexins
- Orthopedic Surgery and Rehabilitation
- Medical History and Research
- Thermoregulation and physiological responses
- Calcium signaling and nucleotide metabolism
- Acute Ischemic Stroke Management
- Liver physiology and pathology
- Organ Donation and Transplantation
- Grief, Bereavement, and Mental Health
Ascension
2025
World Health Organization - Nigeria
2024
University Hospital of Geneva
2019
Zero to Three
2015
Research Center Borstel - Leibniz Lung Center
2008-2012
University of Manchester
2010
Institute of Medical Microbiology and Hygiene
2004-2006
Penn State Milton S. Hershey Medical Center
2000
Purdue University West Lafayette
1997
University of Milan
1991-1994
The obligate intracellular pathogen Leishmania major survives and multiplies in professional phagocytes. evasion strategy to circumvent killing by host phagocytes establish a productive infection is poorly understood. Here we report that the virulent inoculum of promastigotes contains high ratio annexin A5-binding apoptotic parasites. This subpopulation parasites characterized round body shape, swollen kinetoplast, nuclear condensation, lack multiplication represents dying or already dead...
Summary A number of immunological functions are dependent on circadian rhythms and regular sleep. This has impact the type magnitude immune responses following antigenic challenge, for example in vaccination. Little is known about underlying mechanisms. One possibility may be sleep-dependent modulation CD4+CD25- T cell by CD4+CD25+ natural regulatory cells (nTreg). In a variety studies, nTreg have been shown to regulate negatively. Thus, we investigated influence sleep rhythm function as...
Abstract The obligate intracellular bacterial pathogen Chlamydia pneumoniae (Cp) is responsible for a range of human diseases, including acute respiratory infection. Although experimental intratracheal infection with Cp results in massive recruitment neutrophil granulocytes (polymorphonuclear neutrophils (PMN)), the role these cells defense against unclear. In this study interactions PMN were investigated. vitro coincubation experiments showed that able to internalize an opsonin-independent...
Regulatory CD8+ T cells are critical for self-tolerance and restricting excessive immune responses. The variety of functions they fulfill, the heterogeneity their phenotype, mechanism action still poorly understood. Here we describe that regulatory exhibiting immunosuppressive actions in vitro vivo recognized as CD38high present naive mice. CD38 is a glycosylated membrane protein with ectonucleotidase properties. CD8+CD38high (CD44+CD122+CD62Lhigh) lymphocytes suppress CD4+ effector T-cell...
Abstract Background Diagnostic stewardship complements antimicrobial by promoting appropriate use of diagnostic tools. While disparities have been reported in antibiotic prescribing and hospital-acquired infections, data are limited on test utilization. We evaluated the association race social vulnerability index (SVI) ordering testing a large diverse health system.Table 1:Diagnostic Test Utilization Race SVI Inpatient Observation encounters Methods Retrospective analysis tests ordered for...
Abstract Background Rising antibiotic resistance is a major public health threat. In 2015 our organization responded by establishing antimicrobial stewardship programs in all acute care facilities. A review of the literature has shown concerning disparities use across different populations, potentially contributing to unequal outcomes. Our an expansive geographic footprint that encompasses diverse patient populations which precipitates need evaluate system.Table 1.Antimicrobial Utilization...
Symptoms of diseases such as rheumatoid arthritis, which is T helper 1 (Th1) dependent, and asthma, 2 (Th2) are influenced by diurnal rhythms natural regulatory cells (nTreg). However, the mechanisms responsible for rhythm disease activity have not been identified it unclear whether nTreg rhythm-dependent. We therefore investigated a 24-hr cycle affected ability various T-cell populations to generate immunomodulatory pro-inflammatory cytokines, well its suppression cells. Using...
Abstract The central oxygen sensitive transcription factor HIF-1α has been implicated in the differentiation of nTreg and Th17 cells to orchestrate metabolic changes activated T cells. However, data on functional relevance Hox, general, for nTreg-suppressive activity cell function primary human are still missing. Therefore, we analyzed effect Hox Tres, nTreg, Under nTreg-mediated suppression Tres proliferation, CD25 expression, secretion IFN-γ were significantly reduced, whereas expression...
Optimizing outcomes of hospitalized patients anchors on standardizing processes in medical management, interventions to reduce the risk decompensation, and prompt intervention when a patient decompensates.
The transcription factor hypoxia inducible factor‐1α (HIF‐1α) mediates the metabolic adaptation of cells to and T‐helper cell fate. However, HIF‐1α regulation in CD4 + T (T cells) remains elusive. Here we observed that depletion oxygen (O 2 ⩽2%) alone was not sufficient induce expression cells. when hypoxic were stimulated, expressed this dependent on nuclear factor‐κB‐ activated (NFAT)‐mediated transcriptional upregulation Hif‐1α mRNA. could be blocked by drugs inhibiting NF‐κB, NFAT or...
Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Twenty prepubertal crossbred gilts (Yorkshire x Hampshire Duroc) weighing 98.1 +/- 4.2 kg at 5 mo of age were placed in an environmentally controlled room having a temperature 18 degrees C and light:dark cycle 12 h:12 h. Light intensity measured 700 lx eye level to the gilts. Three mature ewes penned adjacent serve as positive controls for light-dark cycles. After 30-d acclimation period, 10 from pool determined be (serum progesterone < 500 pg/mL) fitted with surgically implanted jugular...
Regulatory T (Treg) cells induce immunologic tolerance by suppressing effector functions of conventional lymphocytes in the periphery. On other hand, immune silencing is mediated recognition phosphatidylserine (PS) on apoptotic phagocytes. Here we describe expression PS-binding protein Annexin V (ANXA5) CD4+ CD25hi Treg at mRNA and levels. ANXA5+ constitute about 0·1%-0·6% peripheral blood CD3+ cells, exhibit co-expression several markers, such as Forkhead box P3, programmed cell death...
When healthy volunteers were treated with human insulin-like growth factor-I (IGF-I), mild generalized edema often developed. In the present study, effect of IGF-I on cutaneous capillary permeability and microvascular skin blood flow was investigated using fluorescence videomicroscopy laser Doppler fluxmetry. Transcapillary diffusion intravenously injected sodium fluorescein (NaF) quantitated by videodensitometry in terms fluorescent light intensities (FLIs) 5, 10, 20, 30, 60, 120, 180 300 s...
Arenas, J.; Gupta, M.; Barnett, K.; Bollinger, A.; Holman, M. Haluck, R. S.; Ahsan, N.; Yang, H. C. Author Information