A5086593391- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Biofuel production and bioconversion
- Nematode management and characterization studies
- Porphyrin Metabolism and Disorders
- Dialysis and Renal Disease Management
- Gut microbiota and health
- Therapeutic Uses of Natural Elements
- Urinary Tract Infections Management
- Cooperative Studies and Economics
- Diet and metabolism studies
- Biliary and Gastrointestinal Fistulas
- Pelvic floor disorders treatments
- Liver Disease and Transplantation
- Urological Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Urinary Bladder and Prostate Research
- MRI in cancer diagnosis
- Central Venous Catheters and Hemodialysis
- Biomedical Research and Pathophysiology
- Hepatocellular Carcinoma Treatment and Prognosis
- Microbial metabolism and enzyme function
- Blood donation and transfusion practices
NYU Langone Health
2015-2025
New York University
2013-2024
HemoCleanse (United States)
2023
Oxalosis and Hyperoxaluria Foundation
2023
Monterey Bay Aquarium Foundation
2023
Craig Technologies (United States)
2023
Hinge Health
2020
Columbia University Irving Medical Center
2017
VA NY Harbor Healthcare System
2015
Saint Louis University Hospital
2010
Increasing evidence shows the importance of commensal microbe Oxalobacter formigenes in regulating host oxalate homeostasis, with effects against calcium kidney stone formation, and other oxalate-associated pathological conditions. However, limited understanding O. humans poses difficulties for designing targeted experiments to assess its definitive sustainable interventions clinical settings. We exploited large-scale dataset from American Gut Project (AGP) study colonization human...
Over-accumulation of oxalate in humans may lead to nephrolithiasis and nephrocalcinosis. Humans lack endogenous degradation pathways (ODP), but intestinal microbes can degrade using multiple ODPs protect against its absorption. The exact oxalate-degrading taxa the human microbiota their ODP have not been described. We leverage multi-omics data (>3000 samples from >1000 subjects) show that primarily uses type II ODP, rather than I. Furthermore, among diverse ODP-encoding microbes, an...
Observational studies have suggested a relationship between the plasma concentration of indoxyl sulfate (IS) and p-cresyl (PCS), small gut-derived 'uremic solutes', high incidence uremic cardiomyopathy in patients with end-stage renal disease (ESRD). IS PCS are derived from metabolism dietary components (tryptophan tyrosine) by gut bacteria. This pilot study was designed to examine effects poorly absorbable antibiotic (vancomycin) on two PCS, composition microbiome.Plasma concentrations were...
Oxalobacter formigenes, a member of the human colonic microbiota with major role in net oxalate transport and secretion, is protective against formation calcium kidney stones. We describe prevalence, relative abundance stability O. formigenes healthy young adults United States.
Enteric hyperoxaluria, a risk factor for kidney stone disease, often arises from malabsorptive bariatric surgeries or inflammatory bowel diseases. Current murine models studying this condition are limited, necessitating new approaches. This study aims to establish two novel and distinct mouse investigate enteric hyperoxaluria: one simulating Roux-en-Y gastric bypass surgery the other Crohn’s ileitis. In first model, diet-induced obese C57BL/6J male mice underwent either sham surgery,...
Abstract There has been increasing interest in the human anaerobic colonic bacterium Oxalobacter formigenes because of its ability to metabolize oxalate, and potential contribution protection from calcium oxalate kidney stones. Prior studies examining prevalence this organism have focused on subjects developed countries adults. Now using O . formigenes- specific PCR, we compared these organisms among two remote areas which modern medical practices hardly present with a USA group mothers...
Declining renal function results in the accumulation of solutes normally excreted by healthy kidneys. Data suggest that some protein-bound mediate accelerated cardiovascular disease. Many poorly dialyzable uremic retention are products gut bacterial metabolism.We performed a blinded-randomized controlled trial comparing changes plasma concentrations panel and microbiome structure response to once-weekly oral administration 250 mg vancomycin or placebo over period 12 weeks cohort stable...
The incidence of kidney stones is increasing in the US population. Oxalate, a major factor for stone formation, degraded by gut bacteria reducing its intestinal absorption. Intestinal O. formigenes colonization has been associated with lower risk recurrent humans. In current study, we used clinical trial eradication Helicobacter pylori to assess effects an antibiotic course on colonization, urine electrolytes, and composition microbiome. Of 69 healthy adult subjects recruited, 19 received...
Hyperoxaluria is a condition in which there pathologic abundance of oxalate the urine through either hepatic overproduction (primary hyperoxaluria [PH]) or excessive enteric absorption dietary (enteric [EH]). Severity can vary with most severe forms causing kidney failure and extrarenal manifestations. To address current challenges innovations hyperoxaluria, 14th International Workshop convened Perugia, Italy, bringing together international experts for focused presentation discussion. The...
Abstract Background Oxalobacter formigenes are bacteria that colonize the human gut and degrade oxalate, a component of most kidney stones. Findings clinical epidemiological studies suggest O. colonization reduces risk for We sought to develop murine models allow investigating in context its native microbiome. Methods For humanization, we transplanted pooled feces from healthy, noncolonized donors supplemented with strain into recipient mice. microbiota mice were treated broad-spectrum...
Oxalate is a highly oxidized dicarboxylic acid ubiquitous to the human diet and produced as an end product of amino metabolism. Lacking endogenous oxalate-metabolizing enzymes, humans are vulnerable oxalate-induced toxicity. By contrast, intestinal microbiota harbors various microbes that can degrade oxalate.1 Particularly Oxalobacter formigenes, commensal uses oxalate its sole energy source, has been associated with lower urinary in animal models.
Enteric hyperoxaluria is a medical condition characterized by elevated urinary oxalate excretion due to increased gastrointestinal absorption. Causative features include fat malabsorption and/or intestinal permeability oxalate. has long been known cause nephrolithiasis and nephrocalcinosis, and, more recently, an association with CKD kidney failure shown. Currently, there are no US Food Drug Administration–approved therapies for enteric hyperoxaluria, it unclear what end points should be...