A5049684814- Pain Mechanisms and Treatments
- Nerve injury and regeneration
- Signaling Pathways in Disease
- Natural Compounds in Disease Treatment
- Hereditary Neurological Disorders
- Nanoparticle-Based Drug Delivery
- Peptidase Inhibition and Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Phytochemistry and biological activity of medicinal plants
- Neuropeptides and Animal Physiology
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
Southern Medical University
2022-2024
Zhujiang Hospital
2024
Nanfang Hospital
2022-2023
Central People's Hospital of Zhanjiang
2022-2023
Mesenchymal stem cell (MSCs)-derived small Extracellular Vesicles (sEVs) are considered as a new cell-free therapy for pain caused by nerve injury, but whether human placental mesenchymal cell-derived sEVs relieve in sciatic injury and its possible mechanism still unclear. In this study, we investigated the roles of hPMSCs-derived related mechanisms neuropathic pain.The spared (SNI) mouse model was employed. Intrathecal injection or miR-26a-5p agomir performed on seventh day modeling, to...
Abstract Background Inflammation often leads to the occurrence of chronic pain, and many miRNAs have been shown play a key role in development inflammatory pain. However, whether miR‐26a‐5p relieves pain induced by inflammation its possible mechanism are still unclear. Methods The complete Freund's adjuvant (CFA)‐induced mouse model was employed. Intrathecal or subcutaneous injection agomir performed after modeling study antinociceptive effect comparison different administration methods....
Abstract Accumulating evidence supports the notion that microglia play versatile roles in different chronic pain conditions. However, therapeutic strategies of by targeting remain largely overlooked. This study seeks to develop a miRNA-loaded nano-delivery system microglia, which could provide decent and long-lasting analgesia for pain. Surface aminated mesoporous silica nanoparticles were adopted load miR-26a-5p, potent analgesic miRNA, electrostatic adsorption, can avoid miR-26a-5p is...
Epigenetic changes in the spinal cord play a key role initiation and maintenance of nerve injury-induced neuropathic pain. N6-methyladenosine (m6A) is one most abundant internal RNA modifications plays an essential function gene regulation many diseases. However, global m6A modification status mRNA at different stages after pain unknown. In this study, we established model mice by preserving complete sural only damaging common peroneal nerve. High-throughput methylated immunoprecipitation...
Celastrol plays a significant role in cerebral ischemia-reperfusion injury. Although previous studies have confirmed that celastrol post-treatment has protective effect on ischemic stroke, the therapeutic of stroke and underlying molecular mechanism remain unclear. In present study, focal transient ischemia was induced by middle artery occlusion (tMCAO) mice administered immediately after reperfusion. We performed lncRNA mRNA analysis hemisphere adult with through RNA-Sequencing (RNA-Seq). A...
Abstract Background: Mesenchymal stem cell (MSCs)-derived exosomes are considered as a new cell-free therapy for pain caused by nerve injury, but whether human placental mesenchymal cell-derived relieve in sciatic injury and its possible mechanism still unclear. In this study, we investigated the roles of hPMSCs-derived related mechanisms neuropathic pain. Methods: The spared (SNI) mouse model was employed. Intrathecal injection or miR-26a-5p agomir performed on seventh day modeling, to...