A5044661566- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Signaling Pathways in Disease
- FOXO transcription factor regulation
- Histone Deacetylase Inhibitors Research
- Neuroscience and Neuropharmacology Research
- Natural Compounds in Disease Treatment
- Nerve injury and regeneration
- Drug Transport and Resistance Mechanisms
- MicroRNA in disease regulation
- Neurological disorders and treatments
- Advanced Electron Microscopy Techniques and Applications
- Cancer-related gene regulation
- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Retinoids in leukemia and cellular processes
- Cell Image Analysis Techniques
- Immune cells in cancer
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Wnt/β-catenin signaling in development and cancer
- Epilepsy research and treatment
- Barrier Structure and Function Studies
Shenzhen Institutes of Advanced Technology
2023-2025
Chinese Academy of Sciences
2024-2025
Southern Medical University
2018-2024
Shenzhen Maternity and Child Healthcare Hospital
2022-2024
Nanfang Hospital
2018-2024
Central People's Hospital of Zhanjiang
2023
Southwest University
2019
Key Laboratory of Guangdong Province
2018
Stroke is the second leading cause of death worldwide, and oxidative stress plays a crucial role. Celastrol exhibits strong antioxidant properties in several diseases; however, whether it can affect oxidation cerebral ischemic-reperfusion injury (CIRI) remains unclear. This study aimed to determine celastrol could reduce damage during CIRI elucidate underlying mechanisms. Here, we found that attenuated by upregulating nuclear factor E2-related 2 (Nrf2). Using alkynyl-tagged liquid...
Abstract The Wnt/β-catenin pathway is critical to maintaining cell fate decisions. Recent study showed that liquid–liquid-phase separation (LLPS) of Axin organized the β-catenin destruction complex condensates in a normal cellular state. Mutations inactivating APC gene are found approximately 80% all human colorectal cancer (CRC). However, molecular mechanism formation by phase and how mutations impact still unclear. Here, we report complex, which constructed Axin, was assembled via process...
The underlying pathophysiological mechanisms of cerebral ischemia reperfusion injury (CIRI) is intricate, and current studies suggest that neuron, astrocyte, microglia, endothelial cell, pericyte all have different phenotypic changes specific cell types after ischemic stroke. And microglia account for the largest proportion CIRI. Previous transcriptomic stroke typically focused on 24 hours CIRI, obscuring dynamics cellular subclusters throughout disease process. Therefore, traditional...
Designer receptors exclusively activated by designer drugs (DREADDs) play important roles in neuroscience research and show great promise for future clinical interventions neurological diseases. The Gs-coupled DREADD, rM3Ds, modulates excitability neuron subsets that are sensitive to downstream effectors of Gs protein. However, given the non-human nature rM3Ds backbone, risks about potential immunogenicity tolerability exist when considering translation. Here, we report development a whole...
Ischemic stroke is one of the leading causes death and disability for adults, which lacks effective treatments. Dietary intake n-3 polyunsaturated fatty acids (n-3 PUFAs) exerts beneficial effects on ischemic by attenuating neuron inflammation induced microglial activation. However, impact mechanism PUFAs astrocyte function during have not yet been well investigated. Our current study found that dietary decreased infarction volume improved neurofunction in mice model transient middle...
Forkhead Box F1 (FOXF1) has been recently implicated in cancer progression and metastasis of lung breast cancer. However, the biological functions underlying mechanisms FOXF1 regulation colorectal (CRC) are largely unknown. We showed that was up-regulated 93 paraffin-embedded archived human CRC tissue, both high expression nuclear location were significantly associated with aggressive characteristics poorer survival patients. The GSEA analysis higher level positively an enrichment EMT gene...
Epigenetic changes in the spinal cord play a key role initiation and maintenance of nerve injury-induced neuropathic pain. N6-methyladenosine (m6A) is one most abundant internal RNA modifications plays an essential function gene regulation many diseases. However, global m6A modification status mRNA at different stages after pain unknown. In this study, we established model mice by preserving complete sural only damaging common peroneal nerve. High-throughput methylated immunoprecipitation...
Celastrol plays a significant role in cerebral ischemia-reperfusion injury. Although previous studies have confirmed that celastrol post-treatment has protective effect on ischemic stroke, the therapeutic of stroke and underlying molecular mechanism remain unclear. In present study, focal transient ischemia was induced by middle artery occlusion (tMCAO) mice administered immediately after reperfusion. We performed lncRNA mRNA analysis hemisphere adult with through RNA-Sequencing (RNA-Seq). A...
Abstract Temporal lobe epilepsy (TLE) is the most common form of medically-intractable epilepsy. Subicular hyperexcitability frequently observed with TLE, presumably caused by impaired inhibition local excitatory neurons. Here, we evaluated effectiveness silencing subicular pyramidal neurons to treat a rodent model TLE. First, generated chronic TLE mouse via initial intrahippocampal kainic acid (IHKA) injection. In state after first IHKA injection, behavioral seizures and histological...
A circuit-based gene therapy strategy for Parkinson's disease (PD) has been shown to significantly reverse core symptoms in both murine and primate PD models. Here, we present a comprehensive workflow specifically manipulate dopamine receptor D
Abstract Lactylation is a newly found lactate-derived post-translational modification, which firstly reported on histone protein lysine residues to regulate gene expression. Here, we provided evidence that higher serum lactate level was possibly associated with better prognosis in ischemic stroke patients. Meanwhile, inhibition of endogenous increased the infarct volume and decreased pan-lactylation affected brain tissue cerebral ischemia mice. We further demonstrated downregulating...
To clarify the suppressive effects of astragalus injection (AI) on different stages early hepatocarcinogenesis induced by weak promotion, SD rats initiated with a single intraperitoneal (i.p.) N-diethylnitrosamine (DEN) at 200 mg/kg body weight and promoted 0.5% piperonyl butoxide (PBO) in diet were repeatedly administered AI 5 ml/kg weight/day postinitiation (EPI) or late (LPI) period for 2 8 weeks, respectively. The number area glutathione S-transferase placental form...