A5100452125- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Pulmonary Hypertension Research and Treatments
- Genomics and Phylogenetic Studies
- MicroRNA in disease regulation
- Genetics and Neurodevelopmental Disorders
- FOXO transcription factor regulation
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer-related gene regulation
- Food Allergy and Anaphylaxis Research
- interferon and immune responses
- Protein Degradation and Inhibitors
- Wnt/β-catenin signaling in development and cancer
- Peroxisome Proliferator-Activated Receptors
- Sleep and related disorders
- ATP Synthase and ATPases Research
- Plant Gene Expression Analysis
- CAR-T cell therapy research
- Bioinformatics and Genomic Networks
- Circular RNAs in diseases
- Obstructive Sleep Apnea Research
- Eicosanoids and Hypertension Pharmacology
Shandong Provincial Hospital
2020-2024
Jiangsu Agri-animal Husbandry Vocational College
2024
Shandong First Medical University
2020-2024
Shenzhen Bao'an District People's Hospital
2024
Hunan Children's Hospital
2023
University of South China
2023
Second Hospital of Shandong University
2023
Northeast Agricultural University
2022
State Key Laboratory of Genetic Engineering
2022
Fudan University
2022
Abstract Cuproptosis caused by copper overload is mediated a novel regulatory mechanism that differs from previously documented mechanisms regulating cell death. Cells dependent on mitochondrial respiration showed increased sensitivity to ionophore elesclomol induced cuproptosis. Maternal embryonic leucine zipper kinase(MELK) promotes tumorigenesis and tumor progression through the PI3K/mTOR pathway, which exerts its effects partly targeting pyruvate dehydrogenase complex(PDHc) reprogramming...
Abstract The Wnt/β-catenin pathway is critical to maintaining cell fate decisions. Recent study showed that liquid–liquid-phase separation (LLPS) of Axin organized the β-catenin destruction complex condensates in a normal cellular state. Mutations inactivating APC gene are found approximately 80% all human colorectal cancer (CRC). However, molecular mechanism formation by phase and how mutations impact still unclear. Here, we report complex, which constructed Axin, was assembled via process...
Human mitochondrial 12S rRNA A1555G mutation has been found to be associated with deafness. However, putative nuclear modifier gene(s) proposed regulate the phenotypic expression of this mutation. In yeast cells, mutant alleles MSS1, encoding a GTP-binding protein, manifest respiratory-deficient phenotype only when coupled 15S P(R)(454) corresponding human This suggests that an MSS1-like gene may influence We report here identification and characterization MSS1 homolog, GTPBP3, first...
Studies of rice protein expression have increased considerably with the development functional genomics. In order to obtain reliable results in western blotting, information on appropriate reference proteins is necessary for data normalization. To date, no published study has identified and systematically validated suitable investigation expression. this study, nine candidate were selected their specific antibodies obtained through immunization rabbits either recombinant expressed...
Objectives: Obstructive sleep apnea (OSA) is an independent risk factor for metabolic syndrome (MetS). Recent studies have indicated that circadian clock genes were dysregulated in OSA. In addition, it clear the impairment of clocks drives progression MetS. Therefore, we hypothesized rhythm disruption links OSA with Methods: A total 118 participants, who underwent polysomnography (PSG) and diagnosed as healthy snorers (control, n = 29) or (n 89) patients based on apnea-hypopnea index (AHI),...
Nuclear gene(s) have been shown to modulate the phenotypic expression of mitochondrial DNA mutations. We report here identification and characterization yeast nuclear gene MTO2 encoding an evolutionarily conserved protein involved in tRNA modification. Interestingly, mto2 null mutants expressed a respiratory-deficient phenotype when coexisting with C1409G mutation 15 S rRNA at very conservative site for human deafness-associated 12 A1491G C1409T Furthermore, overall rate translation was...
Oat is a food and forage crop species widely cultivated worldwide, it also an important grass in plateau regions of China, where there high level ultraviolet radiation sunlight. Screening suitable reference genes for oat under UV-B high-light stresses prerequisite ensuring the accuracy real-time quantitative PCR (qRT–PCR) data used plant adaptation research. In this study, eight candidate (sulfite oxidase, SUOX; victorin binding protein, VBP; actin-encoding, Actin1; protein PSK SIMULATOR...
BACKGROUND: Coronary artery disease (CAD) is a common coronary disease. The functional mechanism of circular RNA (circRNA) HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (circ_HECW2, hsa_circ_0057583) in ox-LDL-treated human cardiac microvascular endothelial cells (hCMECs) still unclear. METHODS: Expression levels circ_HECW2, microRNA (miR)-942-5p, toll-like receptor 4 (TLR4) were analyzed by quantitative real-time PCR (qRT-PCR) western blot assays. Cell proliferation...
Abstract Our study presents the assembly of a high-quality Taihu goose genome at Telomere-to-Telomere (T2T) level. By employing advanced sequencing technologies, including Pacific Biosciences HiFi reads, Oxford Nanopore long Illumina short and chromatin conformation capture (Hi-C), we achieved an exceptional assembly. The T2T encompasses total length 1,197,991,206 bp, with contigs N50 reaching 33,928,929 bp scaffold attaining 81,007,908 bp. It consists 73 scaffolds, 38 autosomes one pair Z/W...
Background: 3M syndrome is a rare autosomal recessive disease, characterized by intrauterine and postnatal growth retardation, facial dysmorphism, large head circumference, skeletal changes, has rarely been reported in the Chinese population. Methods: We describe clinical manifestations gene variants four sporadic cases of individuals from different families. Results: All had significant relative macrocephaly, typical features. Exome sequencing revealed that two patients with homozygous CUL7...
Background: The hypoxia-induced pro-proliferative and anti-apoptotic characteristics of pulmonary arterial endothelial cells (PAECs) play critical roles in vascular remodeling contribute to hypoxic hypertension (PAH) pathogenesis. However, the mechanism underlying this disease has not been fully elucidated. Methods: Bioinformatics was adopted screen out key hypoxia-related genes PAH. Gain- loss-function assays were then performed test identified pathways vitro. Human PAECs cultured under (3%...
ABSTRACT Allergic rhinitis (AR) is one of the most frequently observed diseases in otorhinolaryngology, a global issue that alters quality life patients. Both B cells and follicular helper T (Tfhs) have important roles allergic diseases. However, how Tfhs interact to modulate pathogenesis remains unclear. In this study, two models were examined, including co‐culture isolated from mouse spleen with cells. To further define mechanism, exosomes Tfh added Bulk RNA sequencing (RNA‐seq) analysis...
Background Coronary artery disease (CAD) is the leading cause of mortality worldwide. We aimed to screen out potential gene signatures and construct a diagnostic model for CAD. Method downloaded two mRNA profiles, GSE66360 GSE60993, performed analyses differential expression, ontology terms, Kyoto Encyclopedia Genes Genomes (KEGG) pathways. The STRING database was used identify protein–protein interactions (PPI). PPI network visualization screening key genes were using Cytoscape software....
Objective:To analyze the significance and factors influencing of CT scan under modified Valsalva maneuver. Methods:Clinical data 52 patients with hypopharyngeal carcinoma diagnosed from August 2021 to December 2022 were collected, all had calm breathing maneuver scan. Compare exposure effect aryepiglottic fold, interarytenoid postcricoid area, piriform fossa apex, posterior wall, glottis each scanning method. The effects age, neck circumference, length, BMI, tumor site, T stage on analyzed....
<h3>Background</h3> Immune checkpoint inhibitors (CPI) have significantly advanced cancer treatment; nevertheless, responses are limited to patient subsets, thereby necessitating additional treatment strategies. Regulatory T-cells (Tregs) a specialized population of CD4+ that maintain normal immune tolerance and homeostasis; however, in the tumor microenvironment (TME), Tregs potent immunosuppressive cells promote evasion reduced clinical response CPI. The transcription factor IKZF2 is...