A5105667209- Renal Diseases and Glomerulopathies
- Urological Disorders and Treatments
- Bladder and Urothelial Cancer Treatments
- Autoimmune Bullous Skin Diseases
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Immune cells in cancer
- PI3K/AKT/mTOR signaling in cancer
- Platelet Disorders and Treatments
- Urologic and reproductive health conditions
- Ear and Head Tumors
- Sperm and Testicular Function
- Allergic Rhinitis and Sensitization
- Ureteral procedures and complications
- Urinary Bladder and Prostate Research
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Computational Drug Discovery Methods
- Soft tissue tumor case studies
- Biochemical effects in animals
- Congenital heart defects research
- Healthcare and Venom Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Head and Neck Cancer Studies
- Cancer and Skin Lesions
Shandong Provincial Hospital
2024-2025
Shandong First Medical University
2024-2025
Central South University
2020-2024
Second Xiangya Hospital of Central South University
2020-2024
Shandong University
2024
Xiangya Hospital Central South University
2024
Third Affiliated Hospital of Southern Medical University
2016-2021
Beijing Shijitan Hospital
2012-2015
Capital Medical University
2012-2015
Qilu Hospital of Shandong University
2013
Cysteine-rich secretory protein 2 (CRISP2) is an important in spermatozoa that plays roles modulating sperm flagellar motility, the acrosome reaction, and gamete fusion. Spermatozoa lacking CRISP2 exhibit low motility abnormal morphology. However, molecular mechanisms underlying reduction of asthenoteratozoospermia (ATZ) remain unknown. In this study, expression rather than its mRNA was observed ejaculated from ATZ patients as compared with normozoospermic males. Subsequently, bioinformatic...
Spermatogenic dysfunction caused by cyclophosphamide (CP) chemotherapy has seriously influenced the life quality of patients. Unfortunately, treatments for CP-induced testicular spermatogenic are limited, and molecular mechanisms not fully understood. For first time, here, we explored effects bone marrow mesenchymal stem cell-derived exosomes (BMSC-exos) on in vitro vivo. BMSC-exos could be taken up spermatogonia (GC1-spg cells). CP-injured GC1-spg cells were cocultured at various doses,...
Prostate cancer (PCa) is poor response to the immunotherapy for its high heterogeneity of immune microenvironment. In this study, we aim introduce a new subtype PCa involving M2 tumour associated macrophages (M2-TAMs).Three hundred and sixty-two patients matched normal prostate tissues were selected from Cancer Genome Atlas Gene Expression Omnibus databases. Patients' infiltration characters then analyzed based on gene expressions. The subtypes identified by method unsupervised hierarchical...
ABSTRACT Messenger RNA (mRNA) has demonstrated immense potential in disease therapeutic applications. The current direction is focused on imparting mRNA with competitive synthetic functions and delicate carrier systems. Here, inspired by the collaborative regulation of growth factors cellular microenvironment, we present novel transition metal carbide/nitride (MXene) hydrogel microneedles loaded a biomimetic triplet formulation (TM) for diabetic wound treatment. Such were composed TM, MXene,...
Objectives Investigations of FOXP3 protein expression in cervical oesophageal cancer cells and the number + lymphocytes infiltrating tumour tissue were undertaken. Methods tumour-infiltrating studied immunohistochemically, samples from 42 cases paracancerous 30 these cases. Results The percentage parenchymal expressing was significantly higher (42.9%, 18/42) than 6.67% (two 30). lymphocyte infiltration more frequent (38.1%, 16/42) (13.33%, four 30) tissue. patients with lymph node metastasis...
Background: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease and poses a global major public health burden. The preparation of Tripterygium wilfordii Hook F (TwHF) widely applied for treating patients with in China, while molecular mechanisms remain unclear. This study aimed to verify therapeutic mechanism TwHF on IgAN by undertaking holistic network pharmacology strategy combination vitro vivo experiments. Methods: active ingredients their targets were...
Abstract CD169+ macrophages are a newly defined macrophage subpopulation that can recognize and bind with other cells through related ligands, playing an essential role in antigen presentation immune tolerance. However, its Allergic Rhinitis (AR) is still unclear. To investigate the characteristics of AR, this work first detects their expression patterns nasal mucosa clinical patients. These results show significant increase patients AR. Subsequently, establishes animal AR model using CD169...
Allergic rhinitis (AR) has emerged as a global concern, particularly due to the recent rise in disease incidence. There is an urgent need for safer, more effective, and shorter-term targeted immunotherapy approaches. Our previous studies have demonstrated potential of paris saponins II mitigating neutrophil infiltration nasal mucosa AR mice. However, its clinical applicability been hampered by limited bio availability bioactivity. In response these limitations, we developed bis-5HT-modified...
ABSTRACT Allergic rhinitis (AR) is one of the most frequently observed diseases in otorhinolaryngology, a global issue that alters quality life patients. Both B cells and follicular helper T (Tfhs) have important roles allergic diseases. However, how Tfhs interact to modulate pathogenesis remains unclear. In this study, two models were examined, including co‐culture isolated from mouse spleen with cells. To further define mechanism, exosomes Tfh added Bulk RNA sequencing (RNA‐seq) analysis...
ABSTRACT Congenital middle ear malformations are a common hearing defect in newborns, primarily characterised by abnormal structures, particularly underdeveloped or malformed ossicular chains, resulting conductive loss. This article provides comprehensive review of the embryonic development process and genetic regulatory mechanisms, with focus on Tbx1 gene, which is closely related to development. Studies have shown that gene plays crucial role migration neural crest cells formation its...
IgA nephropathy (IgAN) is the most common primary glomerular disease in China, but its pathogenesis remains unclear. This study aims to explore regulatory role of mammalian target rapamycin (mTOR) signaling pathway autophagy and mesangial proliferation during renal injury IgA. The activity mTOR was evaluated kidney samples from IgAN patients an mouse model induced by oral bovine serum albumin carbon tetrachloride (CCl4) injection. inhibitors (rapamycin) activators [bpV(phen)] were...
<p>Escopoletin, a phenolic compound belonging to anthocyanin family shows promising antioxidant activities. In the present study, anti-cancer effects of escopoletin treatment in DU145 cells were investigated. The sulphorhodamine-B staining and annexin V propidium iodide respectively used for analysis cell viability death. results revealed significantly higher cytotoxicity by that caused death cells. Escopoletin markedly inhibited growth through non-apoptotic induced significant...
Objective To investigate the changes of rats' benign hyperplasia prostate glandular epithelium cells after continuing blockade cholinergic innervation by drug.Methods All 42 male spontaneous hypertension rats (SHR,a BPH animal model,29 weeks old) were divided into experiment group (EG),control (CG) and normal control (NC).EG intragastric administered with Tolterodine (3.5 mg/kg,bid),CG equivalent physiological saline.Rats sacrificed in batches every 12 weeks,the gross morphology,ratio...
This paper have completed the structural design of GF3.5 25/500, and cover high pressure vessel, flange, body vessel was stress check, security last combination tests, air tightness test, Commissioning completion three major test final design.
Objective To discuss the diagnosis,therapy and prognosis of primary ureter transitional cell carcinoma with low stage grade.Methods Retrospective review 18 cases surgery to treat G1-2 Ta-2 was carried out.There were 12 males 6 females mean age 67 years.Of size tumor from 0.5 1.5 cm.13 had tumors on left 5 right.The located at middle parts in 3 cases,and lower part 15 cases.The course disease days months.10 gross hematuria 8 renal hydronephrosis found incidentally by B-ultrasound.B-ultrasound...
Aim: To deepen the understanding of patients with seminal vesicle cysts for correct diagnosis and treatment. Patients Methods: Five were treated over period January 1996–May 2010. Their symptoms, diagnostic results, treatment outcomes analysed retrospectively. The mean age these at was 35 years (range: 20–45). Symptoms included haematospermia in three patients, urinary frequency perineal malaise four infertility pain after ejaculation scrotal dysuria one patient. Cysts palpable on digital...
Objective To discuss the cause,treatment and prevention of splenic injury during urological surgery.Methods The clinical data 16 cases with in operation for renal adrenal tumors 496 were retrospectively analyzed.Nine left radical nephrectomy,3 hamartoma enucleation,4 tumor resection.Damage located at outer edge spleen 8 cases,the splenorenal ligament 6 cases,and hilum 2 cases.In these cases,14 patients spared (Ⅰ Grade cases,Ⅱ grade cases).The injuryed was directly pressed hemostatic gauze 3...