A5101795081- Pain Mechanisms and Treatments
- Protein Hydrolysis and Bioactive Peptides
- Advanced Glycation End Products research
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Biochemical effects in animals
- Nerve injury and regeneration
- Proteins in Food Systems
- Adipose Tissue and Metabolism
- Metabolism and Genetic Disorders
- Meat and Animal Product Quality
- EEG and Brain-Computer Interfaces
- Spine and Intervertebral Disc Pathology
- Fatty Acid Research and Health
- Histone Deacetylase Inhibitors Research
- Mast cells and histamine
- Origins and Evolution of Life
- Biochemical and Molecular Research
- Neuropeptides and Animal Physiology
- Asthma and respiratory diseases
- HIV/AIDS drug development and treatment
- Cancer Mechanisms and Therapy
- Neurological Disease Mechanisms and Treatments
- Estrogen and related hormone effects
- Biopolymer Synthesis and Applications
Central South University
2024
Second Xiangya Hospital of Central South University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2002-2021
Peking Union Medical College Hospital
2011-2021
Central People's Hospital of Zhanjiang
2021
University of Pittsburgh
2017-2020
Union Hospital
2017-2020
Huazhong University of Science and Technology
2017-2019
Tongji Hospital
2019
Sichuan Agricultural University
2014-2015
In most cells, mitochondria are highly dynamic organelles that constantly fuse, divide and move. These processes allow to redistribute in a cell exchange contents among the mitochondrial population, subsequently repair damaged mitochondria. However, studies on dynamics have been performed cultured lines neurons, little is known about whether vivo, especially specialized differentiated adult skeletal muscle cells. Using matrix-targeted photoactivatable green fluorescent protein (mtPAGFP)...
Pancreatic cancer (PC) is one of the most lethal diseases, and effective treatment PC patients remains an enormous challenge. Rocaglamide A (Roc-A), a bioactive molecule extracted from plant Aglaia elliptifolia, has aroused considerable attention as therapeutic choice for numerous treatments. Nevertheless, effects underlying mechanism Roc-A in are still poorly understood. Here, we found that inhibited growth stimulated apoptosis by induction mitochondria dysfunction PC. Moreover, accelerated...
Ischemic stroke is one of the leading causes death and disability for adults, which lacks effective treatments. Dietary intake n-3 polyunsaturated fatty acids (n-3 PUFAs) exerts beneficial effects on ischemic by attenuating neuron inflammation induced microglial activation. However, impact mechanism PUFAs astrocyte function during have not yet been well investigated. Our current study found that dietary decreased infarction volume improved neurofunction in mice model transient middle...
During sepsis and shock states, mitochondrial dysfunction occurs. Consequently, adaptive mechanisms, such as fission, fusion, mitophagy, are induced to eliminate damaged portions or entire dysfunctional mitochondria. The regulatory PINK1/Parkin DJ-1 pathways strongly by depolarization, although a direct link between loss of membrane potential (ΔΨ) mitophagy has not been identified. Mitochondria also buffer Ca2+, their buffering capacity is dependent on ΔΨ Here, we characterize role for...
Objectives To study the function of in vivo chymase on heart remodeling by overexpression human transgenic mice. Methods Transgenic mice were produced microinjection. The mRNA levels and other tissues assessed competitive reverse transcriptase–polymerase chain reaction (RT-PCR). expression collagen I/III genes was analyzed Northern blot hybridization. Chymase angiotensin-converting enzyme (ACE) activities, angiotensin II (Ang II) content determined radioimmunoassay (RIA). matrix...
The pathogenesis of diabetic neuropathic pain is complicated and its underlying mechanisms remain unclear. Calmodulin-dependent protein kinases (CaMKs) IV (CaMKIV), one CaMKs, regulates several transcription factors in mechanisms. High-mobility group box 1 (HMGB1) a key mediator pain. This study aims to find the roles CaMIV Diabetic animal models were constructed by injecting with streptozotocin (STZ) intraperitoneally. They randomly divided into seven groups (n = 6 per group): Naive, Normal...
Diabetic neuropathic pain is a common complication of diabetes mellitus and requires substantial amount societal resources. Pyridoxamine an inhibitor advanced glycation lipoxidation end products. Several animal clinical studies have confirmed that pyridoxamine can inhibit range pathological changes in diabetes-induced organ injury alleviate certain kinds pain. However, no attempted to explore the effects on diabetic We conducted experiments examine whether could mechanism underlying these...
Amino acid phosphoramidates of adenosine were synthesized and determined by positive negative ion electrospray ionization mass spectrometry (ESI-MS) in conjunction with tandem (MS/MS). The fragmentation pathways investigated. In the spectra abundant characteristic fragment ions appeared, many complementary found. only a few observed, most them contained phosphoryl groups. results show that ESI-MS is useful tool for structural determination amino nucleosides.