A5103224770- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Marine animal studies overview
- Ion Channels and Receptors
- Connexins and lens biology
- Cephalopods and Marine Biology
- Biochemical Analysis and Sensing Techniques
- Noise Effects and Management
- Immune Response and Inflammation
- Ion channel regulation and function
- Bat Biology and Ecology Studies
- Ear Surgery and Otitis Media
- Plant Molecular Biology Research
- Marine Invertebrate Physiology and Ecology
- Neuroscience and Neuropharmacology Research
- RNA regulation and disease
- RNA and protein synthesis mechanisms
- Erythrocyte Function and Pathophysiology
- Calpain Protease Function and Regulation
- Neurobiology and Insect Physiology Research
- Animal Vocal Communication and Behavior
- Coral and Marine Ecosystems Studies
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
Inserm
2012-2023
Université de Montpellier
2001-2023
Institute for Neurosciences of Montpellier
2008-2021
Délégation Paris 5
2019
Université Paris Cité
2019
Centre National de la Recherche Scientifique
2019
Hôpital Saint Eloi
1990-2017
Centre de Référence Déficits Immunitaires Héréditaires
1990-2007
Hôpital Saint Charles
1983-1998
Aix-Marseille Université
1980
Sound-evoked compound action potential (CAP), which captures the synchronous activation of auditory nerve fibers (ANFs), is commonly used to probe deafness in experimental and clinical settings. All ANFs are believed contribute CAP threshold amplitude: low sound pressure levels activate high-spontaneous rate (SR) fibers, increasing gradually recruit medium- then low-SR fibers. In this study, we quantitatively analyze contribution 6 days after 30-min infusion ouabain into round window niche....
The acoustic intermodulation distortion product (2f1–f2) was recorded in the ear canal of two different types normally hearing mice and four hearing-impaired mutant mice. In animals, primary tones at levels 60- to 100-dB SPL evoked emissions (DP’s) 20–50 dB below levels. mutants level dependent on particular type auditory dysfunction associated with mutation. both deafness viable dominant spotting mutants, where either whole organ Corti or stria vascularis is affected by mutation, no DP’s...
Mutations in the type II transmembrane serine protease 3 (TMPRSS3) gene cause non-syndromic autosomal recessive deafness (DFNB8/10), characterized by congenital or childhood onset bilateral profound hearing loss. In order to explore physiopathology of TMPRSS3 related deafness, we have generated an ethyl-nitrosourea-induced mutant mouse carrying a protein-truncating nonsense mutation Tmprss3 (Y260X) and functional histological consequences deficiency. Auditory brainstem response revealed that...
Abstract Jellyfishes represent a group of species that play an important role in oceans, particularly as food source for different taxa and predator fish larvae planktonic prey. The massive introduction artificial sound sources the oceans has become concern to science society. While we are only beginning understand non-hearing specialists like cephalopods can be affected by anthropogenic noises regulation is underway measure European water noise levels, still don’t know yet if impact may...
There is a considerable lack of information concerning marine invertebrate sensitivity to sound exposure. However, recent findings on cuttlefish and octopi showed that exposure artificial noise had direct consequence the functionality physiology statocysts, sensory organs, which are responsible for their equilibrium movements in water column. Owing available data deep diving cephalopod species, we conducted comparative experiment one Mediterranean squid, Illex coindetii, European squid...
Wolfram syndrome (WS) is a rare neurodegenerative disorder encompassing diabetes mellitus, insipidus, optic atrophy, hearing loss (HL) as well neurological disorders. None of the animal models pathology are presenting with an early onset HL, impeding understanding role Wolframin (WFS1), protein responsible for WS, in auditory pathway. We generated knock-in mouse, Wfs1E864K line, human mutation leading to severe deafness affected individuals. The homozygous mice showed profound post-natal HL...
AbstractIn the cochlea, mammalian auditory organ, fibrocytes of mesenchymal nonsensory regions play important roles in cochlear physiology, including maintenance ionic and hydric components endolymph. Occurrence human deafness fibrocyte alterations underlines their critical function. We recently described a novel gene, Otos, which encodes otospiralin, small protein unknown function that is produced by cochlea vestibule. now have generated mice with deletion Otos found they show moderate...
Transdifferentiation of nonsensory supporting cells into sensory hair occurs naturally in the damaged avian inner ear. Such transdifferentiation was achieved experimentally cochlea deaf guinea pigs through Atoh 1 gene transfection. Supporting may therefore serve as targets for therapy. rapidly degenerate after cell disappearance, however, limiting therapeutic window transfer. We studied time course ultrastructural and phenotypical changes occurring Deiters (hair cells) ototoxic treatment...
In a previous paper we demonstrated physiologically sensitive period for acoustic trauma in the rat pup cochlea, with maximum at 22 days of age. Seven or 60 after noise exposure these 22-day exposed rats were used light and electron microscopy. At 7 days, surface preparation revealed restricted damage to basal cochlear coil, while microscopy signs cytoplasmic degeneration appeared great majority coil structures. Two months structures have completely degenerated. These results discussed terms...
Mutations in the Pejvakin ( PJVK ) gene are thought to cause auditory neuropathy and hearing loss of cochlear origin by affecting noise-induced peroxisome proliferation hair cells neurons. Here we demonstrate that pejvakin cells, but not neurons, causes profound outer cell degeneration mice. binds colocalizes with rootlet component TRIOBP at base stereocilia injectoporated a pattern is disrupted deafness-associated mutations. Hair pejvakin-deficient mice develop normal rootlets, bundle...
Abstract The last hundred years have seen the introduction of many sources artificial noise in sea environment which shown to negatively affect marine organisms. Little attention has been devoted how much this could sessile Here, we report morphological and ultrastructural changes seagrass, after exposure sounds a controlled environment. These results are new aquatic plants pathology. Low-frequency produced alterations Posidonia oceanica root rhizome statocysts, sense gravity process sound...