A5021290560- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Osteoarthritis Treatment and Mechanisms
- CAR-T cell therapy research
- Mesenchymal stem cell research
- Mitochondrial Function and Pathology
- Bone health and treatments
- Bone Metabolism and Diseases
- Periodontal Regeneration and Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Ion channel regulation and function
- Metabolism and Genetic Disorders
- Nuclear Structure and Function
- Genetic Neurodegenerative Diseases
- Human-Animal Interaction Studies
- Peripheral Neuropathies and Disorders
- Biochemical Analysis and Sensing Techniques
- vaccines and immunoinformatics approaches
- Extracellular vesicles in disease
- Molecular Communication and Nanonetworks
- ATP Synthase and ATPases Research
- Genetics and Neurodevelopmental Disorders
- Vestibular and auditory disorders
- Immune cells in cancer
Université de Montpellier
2012-2025
Inserm
2012-2025
Hôpital Saint Eloi
2011-2024
Institute for Regenerative Medicine & Biotherapy
2015-2018
Centre Hospitalier Universitaire de Montpellier
2015
Institute for Neurosciences of Montpellier
2004
CLIP-170 is a microtubule “plus-end-tracking protein” implicated in the control of dynamics, dynactin localization, and linking endosomes to microtubules. To investigate function mouse CLIP-170, we generated knockout GFP-CLIP-170 knock-in alleles. Residual detected lungs embryos homozygous mice, but not other tissues cell types, indicating that have hypomorphic mutant. Homozygous mice are viable appear normal. However, male subfertile produce sperm with abnormal heads. Using followed...
Dominant optic atrophy is a rare inherited nerve degeneration caused by mutations in the mitochondrial fusion gene OPA1. Recently, clinical spectrum of dominant has been extended to frequent syndromic forms, exhibiting various degrees neurological and muscle impairments frequently found diseases. Although characterized specific loss retinal ganglion cells, pathophysiology still poorly understood. We generated an Opa1 mouse model carrying recurrent Opa1(delTTAG) mutation, which 30% all...
teaching and research institutions in France or abroad, from public private centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques niveau recherche, publiés ou non, émanant des établissements d'enseignement recherche français étrangers, laboratoires publics privés.
Mutations in the type II transmembrane serine protease 3 (TMPRSS3) gene cause non-syndromic autosomal recessive deafness (DFNB8/10), characterized by congenital or childhood onset bilateral profound hearing loss. In order to explore physiopathology of TMPRSS3 related deafness, we have generated an ethyl-nitrosourea-induced mutant mouse carrying a protein-truncating nonsense mutation Tmprss3 (Y260X) and functional histological consequences deficiency. Auditory brainstem response revealed that...
Regulatory T (Treg) cells play a crucial role in preventing autoimmune diseases and are an ideal target for the development of therapies designed to suppress inflammation antigen-specific manner. Type 1 regulatory (Tr1) defined by their capacity produce high levels interleukin 10 (IL-10), which contributes ability pathological immune responses several settings. The aim this study was evaluate therapeutic potential collagen type II–specific Tr1 (Col-Treg) two models rheumatoid arthritis (RA)...
Objective Mesenchymal stem cells (MSCs) are potent immunosuppressive that have shown promise in the treatment of rheumatoid arthritis (RA). Deciphering intrinsic characteristics MSCs correlate with their biologic activity will facilitate clinical use. Recently, role glucocorticoid‐induced leucine zipper (GILZ) development RA has been documented. The aim this study was to evaluate whether GILZ expression by may contribute therapeutic effect. Methods were isolated from GILZ‐deficient (GILZ −/−...
Wolfram syndrome (WS) is a rare neurodegenerative disorder encompassing diabetes mellitus, insipidus, optic atrophy, hearing loss (HL) as well neurological disorders. None of the animal models pathology are presenting with an early onset HL, impeding understanding role Wolframin (WFS1), protein responsible for WS, in auditory pathway. We generated knock-in mouse, Wfs1E864K line, human mutation leading to severe deafness affected individuals. The homozygous mice showed profound post-natal HL...
The aim of this study was to provide an in-depth longitudinal locomotor and structural characterisation the collagenase-induced osteoarthritis (CIOA) mouse model, using most relevant up-to-date non-invasive phenotyping imaging methods. ultimate goal predict histological scores, gold standard parameter in (OA), based on or deficits. CIOA model induced C57BL/6 male mice, which were then maintained their home cage with without a running wheel for 6 weeks. Both global fine effects measured open...
et à la diffusion de documents scientifiques niveau recherche, publiés ou non, émanant des établissements d'enseignement recherche français étrangers, laboratoires publics privés.
Fragile X Syndrome (FXS) is caused by a deficiency in Mental Retardation Protein (FMRP) leading to global sensorial abnormalities, among which visual defects represent critical part. These are associated with cerebral neuron immaturity especially the primary cortex. However, we recently demonstrated that retinas of adult Fmr1-/y mice, FXS murine model, present molecular, cellular and functional alterations. no data currently available on evolution pattern such defects. As retinal stimulation...
Promising immunotherapeutic strategies are emerging to restore tolerance in autoimmune diseases by triggering an increase the number and/or function of endogenous regulatory T (Treg) cells, which actively control pathological immune responses. Evidence suggests a remarkable heterogeneity peripheral Treg cells that warrants their better characterization terms phenotype and suppressive function, determine subset may be optimally suitable for given clinical situation. We found repetitive...
Initially discovered for its ability to regenerate ear holes, the Murphy Roth Large (MRL) mouse has been subject of multiple research studies aimed at evaluating other body tissues and deciphering mechanisms underlying it. These enhanced abilities regenerate, retained during adulthood, protect MRL from degenerative diseases such as osteoarthritis (OA). Here, we hypothesized that mesenchymal stromal/stem cells (MSC) derived regenerative could be involved in their potential through release...
Abstract Background In the collagen-induced arthritis (CIA) mouse model, inflammation readouts are usually quantified using operator-dependent clinical scoring systems, and no systematic relationship with functional deficits has been detected. this study, we extensively sensory motor in CIA mice during natural disease progression therapeutic treatment. Then, used these data to build a scale predict on basis of classical score. Methods Using longitudinally screened multiple approaches assess...
Science & Society4 November 2021Open Access Towards best practices in research Role of academic core facilities Leonardo Restivo Corresponding Author [email protected] orcid.org/0000-0002-3709-5504 Neuro-BAU, Department Fundamental Neuroscience, Faculty Biology Medicine, University Lausanne, Switzerland These authors contributed equally to this work Search for more papers by author Björn Gerlach orcid.org/0000-0002-4900-6302 PAASP GmbH, Heidelberg, Germany Michael Tsoory...
<h3>Background</h3> Adoptive transfer of regulatory T cells (Tregs) is a promising approach to restore tolerance in autoimmune diseases. However based on the heterogeneity Tregs, we need precisely establish which Tregs will be able dampen efficiently immune response various settings. We previously showed potential CD49b<sup>+</sup> Treg protect and prevent an experimental model arthritis. Nevertheless optimal injection dose, phenotype <i>in vivo</i>-suppressive mechanism these remain...
Abstract Background: Initially discovered for its ability to regenerate ear holes, the MRL mouse has been subject of multiple research studies aimed at evaluating other body tissues and deciphering mechanisms underlying it. These enhanced abilities regenerate, retained in adult, protect from degenerative diseases such as osteoarthritis (OA). Here, we hypothesized that MSC derived regenerative could be involved their potential through release pro-regenerative mediators. Method: To address...
<h3>Background and Objectives</h3> Adoptive cell transfer of Treg cells is a promising approach to restore tolerance in autoimmune disease. However the various type Tregs, their doses injection vivo-suppressive mechanism need be precisely define clearly establish which Tregs will able dampen efficiently immune response settings. In our study, we compared therapeutic potential IL10-secreting Tregs: Tr1 CD49b-induced CD25<sup>+</sup>FoxP<sup>+</sup> Tregs. These two populations share several...
Abstract Background Initially discovered for its ability to regenerate ear holes, the MRL mouse has been subject of multiple research studies aimed at evaluating other body tissues and deciphering mechanisms underlying it. These enhanced abilities regenerate, retained in adult, protect from degenerative diseases such as osteoarthritis (OA). Here, we hypothesized that MSC derived regenerative could be involved their potential through release pro-regenerative mediators. Method To address this...
Background Adoptive cell transfer of Treg cells is a promising approach to restore tolerance in autoimmune disease. However the various type Tregs, their doses injection and vivo-suppressive mechanism need be precisely define clearly establish which Tregs will able dampen efficiently immune response settings. In our study, we compared therapeutic potential induced CD25FoxP3 two IL10-secreting Tregs: Tr1 CD49b-induced Tregs.
<h3>Backgroundand objectives</h3> Adoptive cell transfer of T regulatory (Treg) cells is a promising approach to restore tolerance in autoimmune disease. However the various type Tregs, their doses injection and vivo-suppressive mechanism need be precisely define clearly establish which Tregs will able dampen efficiently immune response settings. In this study, authors compared therapeutic potential two IL10-secreting Tregs: Tr1 CD49b-induced Tregs. The previously demonstrated that single...