Pulmonary arterial hypertension (PAH), characterized as a resting mean pulmonary artery pressure greater than 25 mmHg, is due to the narrowing of arteries, which can be idiopathic, inherited, or drug-related. Alkylating agents, including cyclophosphamide, are risk factor for developing veno-occlusive disease. Drug-induced PAH extremely rare. A 59-year-old female with newly diagnosed invasive ductal carcinoma right breast and high-grade in situ left was initiated treatment doxorubicin...

Epiglottitis is an uncommon, potentially fatal infection of the epiglottis that can lead to complete upper airway obstruction. Isolated pathogens are usually nasopharyngeal bacteria, most commonly Haemophilus influenzae type b (Hib). While incidence epiglottitis has diminished significantly over years due widespread vaccination against Hib, proportion caused by other increased. In this report, we introduce unseen presentation acute associated with severe respiratory distress...

Abstract Background Prior reports have suggested a possible increase in the frequency of invasive fungal infections (IFIs) with use Bruton tyrosine kinase inhibitor (BTKi) for treatment chronic lymphoid malignancies such as lymphocytic leukemia (CLL), but precise estimates are lacking. We aim to characterize prevalence IFIs among patients CLL, whom BTKi is now first-line recommended therapy. Methods queried TriNetX, global research network database, identify adult CLL using International...

The majority of available data on molnupiravir come from an unvaccinated COVID-19 population. Therefore, we conducted this meta-analysis to integrate evidence recent randomized controlled trials (RCTs) as well observational studies stratified by vaccination status determine the clinical efficacy and safety in outpatients.

Bruton's tyrosine kinase inhibitors (BTKis) are the preferred treatment for chronic lymphocytic leukemia (CLL). Despite their therapeutic benefits, these targeted agents have been associated with an increased risk of invasive infections. We describe a 68-year-old male who developed multiple bacterial, fungal and viral infections while on acalabrutinib. To our knowledge, this is first reported case concomitant CNS

Background Antimicrobial resistance is on the rise. The use of redundant and inappropriate antibiotics contributing to recurrent infections resistance. Newer with more robust coverage for Gram-negative bacteria are in great demand complicated urinary tract (cUTIs), intra-abdominal (cIAIs), hospital-acquired bacterial pneumonia (HABP), ventilator-associated (VABP). Materials methods We performed this meta-analysis evaluate efficacy safety profile a new antibiotic,...

Background Normal saline solution (NSS) has been the fluid of choice for renal transplant patients, but it can lead to hyperchloremic acidosis and hyperkalemia. This study was performed compare safety profile low-chloride solutions with that NSS in patients. Methods We conducted a systemic review search on PubMed, Embase, Central Cochrane Registry. Randomized clinical trials (RCTs) matched cohort studies involving as control arm an intervention were chosen. The standardized mean difference...

We report an interesting case of a middle-aged gentleman who presented with diabetic ketoacidosis (DKA) and tested polymerase chain reaction (PCR) positive for COVID-19 infection. His hospital stay was complicated by acute kidney injury, hematuria, normocytic anemia. Initial chest x-ray demonstrated bibasilar opacities. D-dimer C-reactive protein were elevated. During his stay, hemoglobin decreased from 13.4 g/dL to 9 g/dL, further workup ferritin 49,081 ng/mL lactate dehydrogenase 1665 U/L....

Human mpox has increasingly been reported worldwide since May 2022, with higher incidence in men who have sex (MSM) and persons living HIV (PLHIV) presentation typical for generalized macules papules.We are describing a case of human mpox, which presented as widespread, atypical round verrucous lesions that went undiagnosed the community six months was treated antibacterials antifungals given similarity to skin manifestations associated endemic mycoses.Suspicion should be high young MSM...

Abstract Nigella sativa is an herbal therapy for various afflictions. It has some potential to be a promising option as efficacious treatment COVID‐19 patients that can contribute global healthcare relatively cheap but evidence of its use from randomized controlled trials (RCTs) limited. Therefore, explore the effect N. in combating COVID‐19, we undertook this meta‐analysis. We searched several databases retrieve all RCTs investigating compared placebo or standard care. used RevMan 5.4...

As coronavirus disease 2019 (COVID-19) vaccines are being increasingly administered worldwide, subsequent side effects, such as myocarditis, pericarditis, and myopericarditis, becoming more common. Our case describes a 64-year-old male who developed chest pain shortness of breath one week after receiving the Moderna (Cambridge, Massachusetts) COVID-19 mRNA vaccine. He was found to have large, left-sided pleural effusion small pericardial effusion. The patient underwent thoracentesis...

Background. Central venous catheters (CVCs) have been frequently associated with septic thrombophlebitis, bacteremia, and emboli. Right-sided infective endocarditis is seen concurrently in patients pulmonary A case of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia emboli secondary to infected peripheral catheter (PVC) reported. Transesophageal echocardiogram (TEE) showed no evidence endocarditis. Case Presentation. 44-year-old female presented E.R. left upper extremity pain...

Abstract Introduction Cronobacter sakazakii is an opportunistic Gram-negative, rod-shaped bacterium which may be a causative agent of meningitis in premature infants and enterocolitis bacteremia neonates adults. While there have been multiple cases C. infections, no acute cholangitis reported humans. Case presentation An 81-year-old male with past medical history basal cell carcinoma, alcoholic liver cirrhosis, transjugular intrahepatic portosystemic shunt procedure, complicated by...

BACKGROUNDClostridioides (formerly Clostridium) difficile infection (CDI) is an increasingly frequent cause of morbidity and mortality in hospitalized patients.Multiple risk factors are documented the literature that includes, but not limited to, antibiotics use, advanced age, gastric acid suppression.Several epidemiological studies have reported increased incidence CDI liver disease patients.Some also demonstrated a higher prevalence nosocomial infections cirrhotic patients. AIMTo use large...

Abstract Background There is a high prevalence of malaria and viral hepatitis in South Africa. Co-infection with Plasmodium (leading to cerebral malaria) E virus (HEV) rare phenomenon. Case presentation A 33-year-old African American male no past medical history developed altered mental status on his return from Ivory Coast. His blood tests were significant for renal liver failure parasite burden 33% the smear. Interestingly, he also had positive result IgM. The patient was effectively...