A5072405390- Childhood Cancer Survivors' Quality of Life
- Hemoglobinopathies and Related Disorders
- Blood donation and transfusion practices
- Adolescent and Pediatric Healthcare
- Iron Metabolism and Disorders
- Global Public Health Policies and Epidemiology
- Acute Lymphoblastic Leukemia research
- Malaria Research and Control
- Global Health and Surgery
- Healthcare Systems and Reforms
- Health Systems, Economic Evaluations, Quality of Life
- Blood transfusion and management
- Mosquito-borne diseases and control
- Global Health and Epidemiology
- Family Support in Illness
Queen Elizabeth Central Hospital
2023-2024
Kamuzu University of Health Sciences
2023-2024
Kamuzu Central Hospital
2023-2024
University of Malawi
2015-2023
Malawi-Liverpool-Wellcome Trust Clinical Research Programme
2021
University of Liverpool
2021
In sub-Saharan Africa, where infectious diseases and nutritional deficiencies are common, severe anaemia is a common cause of paediatric hospital admission, yet the evidence to support current treatment recommendations limited. To avert overuse blood products, World Health Organisation advocates conservative transfusion policy recommends iron, folate anti-helminthics at discharge. Outcomes unsatisfactory with high rates in-hospital mortality (9–10 %), 6-month relapse (6 %). A definitive...
Summary The phase III Transfusion and Treatment of severe anaemia in African Children Trial (TRACT) found that conservative management uncomplicated [haemoglobin (Hb) 40–60 g/l] was safe, transfusion volume (20 vs. 30 ml/kg whole blood equivalent) for children with (Hb <60 g/l) had strong but opposing effects on mortality, depending fever status (>37·5°C). In 2020 a stakeholder meeting paediatric groups from Africa reviewed the results additional analyses. Among all 3196 receiving an...
Brain swelling is associated with death from cerebral malaria, but it unclear whether brain caused by edema or vascular congestion-two pathological conditions distinct effects on tissue hemoglobin concentrations. We used near-infrared spectroscopy (NIRS) to noninvasively study microvascular concentrations in 46 Malawian children malaria. Cerebral malaria was defined the presence of parasite Plasmodium falciparum a blood smear, Blantyre coma score 2 less, and retinopathy. Children...
Collaborative research generating local evidence is key to closing the and survival gap between sub-Saharan Africa high-income countries. Lessons learned by CANCaRe Africa, African Network for Childhood Cancer Care Research while pioneering such are being discussed together with recommendations future.
The authors declared no conflict of interest
The authors declare they have no conflicts of interest. Data sharing not applicable to this article as datasets were generated or analysed during the current study.
Cost effectiveness of support with out-of-pockets costs to prevent treatment abandonment in Malawi and sub-Saharan Africa; lessons learnt the way forward – a report from CANCaRe Africa Junious Sichali1, Avi Denburg2, Harriet Khofi3, Cecilia Mdoka1, Deborah Nyirenda4, Yamikani Chimalizeni3, George Chagaluka3, Elizabeth Molyneux3, Marc Y. R. Henrion4,5, Sumit Gupta2, Trijn Israels11 Collaborative African Network for Childhood Cancer Care Research (CANCaRe Africa), 2Division...