A5063990546- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Lung Cancer Treatments and Mutations
- Clinical Nutrition and Gastroenterology
- Cancer Immunotherapy and Biomarkers
- Diet and metabolism studies
- Curcumin's Biomedical Applications
- Proteins in Food Systems
- Prenatal Substance Exposure Effects
- Peptidase Inhibition and Analysis
- Surfactants and Colloidal Systems
- Pharmacology and Obesity Treatment
- Bee Products Chemical Analysis
- Lipid Membrane Structure and Behavior
- Lung Cancer Research Studies
- Gastric Cancer Management and Outcomes
- Economic and Financial Impacts of Cancer
- Bladder and Urothelial Cancer Treatments
- Colorectal Cancer Treatments and Studies
- Vitamin K Research Studies
- Urinary and Genital Oncology Studies
- Microscopic Colitis
- Child Nutrition and Water Access
- Pneumocystis jirovecii pneumonia detection and treatment
- Chronic Myeloid Leukemia Treatments
Hospital Quirón Torrevieja
2019-2022
Universidad Católica San Antonio de Murcia
2021
Universitat de València
2011-2018
Universitat Politècnica de València
2012-2018
University of Cagliari
2016-2017
Abstract Background Muscle invasive urothelial bladder carcinoma (MIBC) present RB1 and TP53 somatic alterations in a variable percentage of tumors throughout all molecular subtypes. MIBCs with neuroendocrine features have high response rate to immunity checkpoint inhibitors (ICIs). Whether the presence co-alterations these 2 genes is relevant their responsiveness ICIs not known. Methods The potential correlation different genomic biomarkers like tumor mutational burden (TMB), single...
Nutriosomes, new phospholipid nanovesicles specifically designed for intestinal protection were developed by simultaneously loading a water-soluble dextrin (Nutriose® FM06) and natural antioxidant (curcumin). Nutriosomes easily fabricated in one-step, organic solvent-free procedure. The stability delivery performances of the vesicles improved adding hydroxypropyl methylcellulose. All small size (mean diameter ∼168 nm), negatively charged (zeta potential ∼-38 mV, irrespective their...
The aim of this study was to prepare diclofenac/hydroxypropylmethylcellulose (HPMC) and diclofenac-loaded nanoparticles/HPMC films as potential systems for ocular delivery.Two different concentration the polymer were used: 1.5 2.0% w/v. Chitosan-hyaluronic acid nanoparticles prepared by ionotropic gelation technique. Nanoparticles characterized transmission electron microscopy, dynamic light scattering, drug encapsulation efficiency rheological studies. In-vitro studies corneal penetration...
The main goal of treatment in cancer patients is to achieve the highest therapeutic effectiveness with least iatrogenic toxicity. Tyrosine kinase inhibitors (TKIs) are anticancer oral agents, usually administered at fixed doses, which present high inter- and intra-individual variability due their pharmacokinetic characteristics. Therapeutic drug monitoring (TDM) can be used optimize use several types medication.We evaluated TDM TKIs routine clinical practice through studying exposure...
Protein energy malnutrition is a public health problem affecting great number of people. Pathophysiological imbalances in malnourished individuals have profound impact on drug pharmacokinetics.To develop an animal model undernutrition using male Wistar rats to be used assess, further studies, the nutritional status oral bioavailability and pharmacokinetics drugs.[corrected] Animals were randomly assigned one two groups fed different diets for 26 days: WN (well-nourished/regular diet, N = 61)...
Malnourishment is a complex condition in which physiopathological changes take place multiple systems as result of energy, protein and nutrient deficiency. The purpose this study was to evaluate, using an experimental animal model, the impact nutritional status on pharmacokinetic profile erlotinib, reversible, highly selective, human epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor. Two groups rats -WN (well-nourished) UN (undernourished) - were fed with different diets...
We describe a clinical case of an 84-year-old man diagnosed with non-small cell lung carcinoma and epidermal growth factor receptor mutation, who was treated erlotinib, doses adjusted by therapeutic drug monitoring. This involved clearance fluctuation leading to over-therapeutic concentrations erlotinib toxicity. The intrapatient interpatient variability in addition other factors such as age or variations liver clearance, create situations that are challenging practice. During treatment,...
Abstract: To study the potential interactions of naringin (NAR), talinolol (TAL) and protein–energy undernutrition (PEU) in absorption process saquinavir (SQV), perfusion experiments were performed small intestine rats at different SQV concentrations. The results obtained demonstrated that intestinal was described by simultaneous passive diffusion (kdif = 3.44 hr) saturable (Vma 127.31 μM/hr; Kma 10.50 μM) together with a capacity-limited efflux (Vms 270.53 Kms 23.44 μM). competitive...
Abstract Malnutrition is a common feature of chronic and acute diseases, often associated with poor prognosis, including worsening clinical outcome, owing, among other factors, to dysfunction the most internal organs systems affecting absorption, metabolism elimination drugs nutrients. Taurine involved in numerous biological processes required increased amounts response pathological conditions. The aim this study was describe behaviour taurine well-nourished (WN) rats analyse influence...
e14089 Background: Fixed dose schemes, regardless of body weight, have been accepted by the regulatory agencies for PD-1 targeting antibodies. Zaho X. and Ratain M. elucidated that mean steady state concentrations nivolumab (N) at flat-doses 240 mg Q2W or 480 Q4W were 57 µg/mL 47 µg/mL, respectively. These levels are very similar to those observed dosage 3 mg/kg Q2W. Considering long half-life N, its mechanism action absence correlation between exposure response toxicity clinically tested...
Background: Protein energy malnutrition is a public health problem affecting great number of people. Pathophysiological imbalances in malnourished individuals have profound impact on drug pharmacokinetics. Objective: To develop an animal model undernutrition using male Wistar rats to be used assess, further studies, the nutritional status oral bioavailability and pharmacokinetics drugs. Desing: Animals were randomly assigned one two groups fed different diets for 26 days: WN...