A5001781113- Immune Response and Inflammation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inflammasome and immune disorders
- Air Quality and Health Impacts
- Antioxidant Activity and Oxidative Stress
- Wound Healing and Treatments
- Mesenchymal stem cell research
- Diabetic Foot Ulcer Assessment and Management
- Respiratory Support and Mechanisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pediatric health and respiratory diseases
- Galectins and Cancer Biology
- Heme Oxygenase-1 and Carbon Monoxide
- Heavy Metals in Plants
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hydrogen's biological and therapeutic effects
- Phytochemistry Medicinal Plant Applications
- Immune cells in cancer
- Chemokine receptors and signaling
Universidade Federal do Rio de Janeiro
2013-2023
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
2023
University of Iowa
2016
Abstract Wallerian degeneration ( WD ) comprises a series of events that includes activation non‐neuronal cells and recruitment immune cells, creating an inflammatory milieu leads to extensive nerve fragmentation subsequent clearance the myelin debris, both which are necessary prerequisites for effective regeneration. Previously, we documented accelerated axon regeneration in animals lacking galectin‐3 G al‐3), molecule associated with clearance. To clarify mechanisms underlying this...
Sepsis is a deadly disease characterized by an overwhelming release of inflammatory mediators and the activation different types cells. This altered state cell activation, termed leukocyte reprogramming, contributes to patient outcome. However, understanding process underlying sepsis role regulatory T cells (Tregs) in remains be elucidated. In this study, we investigated CCR4, CCL17/CCL22 chemokine receptor, innate acquired immune responses during severe Tregs effecting contrast with...
The precise context in which the innate immune system is activated plays a pivotal role subsequent instruction of CD4+ T helper (Th) cell responses. Th1 responses are downregulated when antigen encountered presence antigen-IgG complexes. To assess if Th17 to subject similar influences complexes we utilized an inflammatory airway disease model immunization mice with Complete Freund's Adjuvant (CFA) and ovalbumin (Ova) induces powerful Ova-specific response. Here show that modification CFA...
Obesity is a chronic condition involving inflammation and oxidative stress that commonly predisposes affected individuals to develop metabolic disorders. We hypothesize Ilex paraguariensis (IP) can modulate underpinning disorders caused by obesity. C57BL/6 mice were fed high-fat diet (HFD group) for 12 weeks. Concomitantly, some treated with roasted IP (15 mg/ml - HFD + IP) or dimethyl fumarate (DMF) as positive control (2 DMF). The group received standard chow water ad libitum. Histological...
Introduction Pulmonary fibrosis is a destructive, progressive disease that dramatically reduces life quality of patients, ultimately leading to death. Therapeutic regimens for pulmonary have shown limited benefits, hence justifying the efforts evaluate outcome alternative treatments. Methods Using mouse model bleomycin (BLM)-induced lung fibrosis, in current work we asked whether treatment with pro-resolution molecules, such as pro-resolving lipid mediators (SPMs) could ameliorate fibrosis....