A5024688299- Research on Leishmaniasis Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Advanced Glycation End Products research
- COVID-19 Clinical Research Studies
- Wound Healing and Treatments
- Vasculitis and related conditions
- Eosinophilic Disorders and Syndromes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Long-Term Effects of COVID-19
- Neuroinflammation and Neurodegeneration Mechanisms
- Diabetic Foot Ulcer Assessment and Management
- Immune Response and Inflammation
- Adenosine and Purinergic Signaling
- Pressure Ulcer Prevention and Management
Universidade Federal do Rio de Janeiro
2020-2024
The severe acute respiratory syndrome coronavirus 2, the agent of ongoing disease 2019 (COVID-19) pandemic, has spread worldwide since it was first identified in November Wuhan, China. Since then, progress pathogenesis linked severity this systemic to hyperactivation network cytokine-driven pro-inflammatory cascades. Here, we aimed identify molecular biomarkers by measuring serum levels inflammatory mediators a Brazilian cohort patients with COVID-19 and healthy controls (HCs). Critically...
Chronic wounds are a public health problem worldwide, especially those related to diabetes. Besides being an enormous burden patients, it challenges wound care professionals and causes great financial cost system. Considering the absence of effective treatments for chronic wounds, our aim was better understand pathophysiology tissue repair in diabetes order find alternative strategies accelerate healing. Nucleotides have been described as extracellular signaling molecules different...
Neutrophils rapidly infiltrate sites of infection and possess several microbicidal strategies, such as neutrophil extracellular traps release phagocytosis. Enhanced infiltration is associated with higher susceptibility to Leishmania infection, but effector response contribution this phenotype uncertain. Here, we show that neutrophils from susceptible BALB/c mice (B/c) produce more NETs in major than those resistant C57BL/6 (B6), which are phagocytic. The absence elastase contributes...
Neutrophils are multifaceted cells that, upon activation, release meshes of chromatin associated with different proteins, known as neutrophil extracellular traps (NETs). Leishmania amazonensis promastigotes and amastigotes induce NET release, we have identified the signaling pathways involved in extrusion activated by promastigotes. Amastigotes maintain infection vertebrate hosts, shown association NETs human biopsies cutaneous leishmaniasis. However, interaction neutrophils remains poorly...
Introduction Pulmonary fibrosis is a destructive, progressive disease that dramatically reduces life quality of patients, ultimately leading to death. Therapeutic regimens for pulmonary have shown limited benefits, hence justifying the efforts evaluate outcome alternative treatments. Methods Using mouse model bleomycin (BLM)-induced lung fibrosis, in current work we asked whether treatment with pro-resolution molecules, such as pro-resolving lipid mediators (SPMs) could ameliorate fibrosis....
Abstract Several studies have shown the importance of purinergic signaling in various inflammatory diseases. In diabetes mellitus, there is an increase activity some nucleotidases suggesting that this may be affected diabetic skin. Thus, aim our study was to investigate effect ADP on wound healing Swis and C57BL/6 mice were pharmacologic induced type 1 submitted a full-thickness excisional model evaluate as topic treatment. Adenosine diphosphate accelerated cutaneous healing, improved new...
ABSTRACT SARS-CoV-2, the causative agent of ongoing COVID-19, has spread worldwide since it was first identified in November 2019 Wuhan. Since then, already demonstrated an exuberant inflammation, cytokine storm, endothelium dysfunction, platelets hyperactivation and aggregation, following T cell exhaustion leading to severe multi-organ damage death COVID-19 patients. Here, we sought identify molecular biomarkers disease severity a Brazilian cohort patients by measuring serum levels...