A5077075666- Muscle Physiology and Disorders
- Wnt/β-catenin signaling in development and cancer
- Cellular Mechanics and Interactions
- Caveolin-1 and cellular processes
- Skin and Cellular Biology Research
- RNA Research and Splicing
- Cardiomyopathy and Myosin Studies
- Signaling Pathways in Disease
- Calpain Protease Function and Regulation
- Adipose Tissue and Metabolism
- Cell Adhesion Molecules Research
- Neurobiology and Insect Physiology Research
- Ubiquitin and proteasome pathways
- Cellular transport and secretion
- Zebrafish Biomedical Research Applications
- Autophagy in Disease and Therapy
- Lipid metabolism and biosynthesis
- Nuclear Structure and Function
- Microtubule and mitosis dynamics
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Liver physiology and pathology
- Marine Sponges and Natural Products
- Developmental Biology and Gene Regulation
- Silk-based biomaterials and applications
Universidade Federal do Rio de Janeiro
2016-2025
Institute of Biomedical Science
2016
Universidade Santa Úrsula
2015
Hospital Universitário Clementino Fraga Filho
2009
Minhaj University Lahore
2006
GTx (United States)
2006
In-Q-Tel
2006
University of Pennsylvania
1990
The present research uncovers the dynamic nature of student discipline. findings show that discipline escalates during school year, more severely for Black students, and racial disparities in ...Researchers have long used end-of-year rates to identify punitive schools, explore sources inequitable treatment, evaluate interventions designed stem both Yet, this approach leaves us ...
Cardiac cells are organized in vivo a complex tridimensional structural organization that is crucial for heart function. While vitro studies can reveal details about cardiac cell biology, usually grown on simplified two-dimensional (2D) environments. To address these differences, we established culture composed of both 2D and three-dimensional (3D)-organized cells. Our results shows significant differences between the two contexts relation to overall morphology cells, contraction ability,...
Neutrophil extracellular traps (NETs) have been associated with several steps of tumor progression, including primary growth and metastasis. One the key features for acquisition metastatic ability is epithelial-mesenchymal transition (EMT), a complex cellular program. In this study, we evaluated isolated NETs in modulating pro-metastatic phenotype human breast cancer cells. Tumor cells were treated then samples generated cell migration, quantitative RT-PCR, western blotting,...
Abstract Figures are essential to convey the main results of scientific articles. Different biomedical research fields have different methodologies and therefore forms data representation. To understand whether there distinct patterns representation, we analyzed how displayed in publications from six fields: Biochemistry Cell Biology, Bioinformatics Computational Clinical Sciences, Oncology Carcinogenesis, Pharmacology Pharmaceutical Zoology. Our show that Graphics were most frequent type...
The epithelial-mesenchymal transition (EMT) is a biological process in which epithelial cells change into mesenchymal with fibroblast-like characteristics. EMT plays crucial role the progression of fibrosis. Classical inducers associated maintenance EMT, such as TGF-β1, have become targets several anti-EMT therapeutic strategies. Natural products from pentacyclic triterpene class emerged promising elements inhibiting EMT. Uvaol found olive trees (Olea europaea L.) known for its...
Glycolytic enzymes reversibly associate with the human erythrocyte membrane (EM) as part of their regulatory mechanism. The site for this association has been described amino terminus band 3, a transmembrane anion transporter. Binding glycolytic to is recognized inhibit glycolysis, since binding inhibits catalytic activity these enzymes, including rate-limiting enzyme 6-phosphofructo-1-kinase (PFK). However, existence putative stimulatory within EM proposed. PFK able other proteins, such...
Tumor aggressiveness is usually associated with metastasis. MDA-MB 231, a triple-negative breast cancer (TNBC), an aggressive type of and early The Rho/ROCK pathway key regulator cell motility involving cytoskeleton regulation through stabilization actin filaments stress fiber formation. In this study we show that Fasudil, ROCK inhibitor, inhibited the migration 231 A549 cells, without altering viability these cells at concentration 10 μM, modified tumor morphology, disorganization fibers...
The cholesterol synthesis inhibitor simvastatin, which is used to treat cardiovascular diseases, has severe collateral effects. We decided comprehensively study the effects of simvastatin in zebrafish development and myogenesis, because been as a model human due its handling easiness, optical clarity embryos, availability physiological structural methodologies. Furthermore, muscle an important target drug. several concentrations at different developmental stages studied survival rate,...
Chronic wounds are a public health problem worldwide, especially those related to diabetes. Besides being an enormous burden patients, it challenges wound care professionals and causes great financial cost system. Considering the absence of effective treatments for chronic wounds, our aim was better understand pathophysiology tissue repair in diabetes order find alternative strategies accelerate healing. Nucleotides have been described as extracellular signaling molecules different...
Colon cancer is one of the most prevalent types in world and leading causes death. The anti-metabolite 5- fluorouracil (5-FU) widely used treatment patients with colon other types. 5-FU-based chemotherapy has been shown to be very efficient improvement overall survival for eradication disease. Unfortunately, common side effects 5-FU include severe alterations motility gastrointestinal tissues. Nevertheless, molecular cellular smooth muscle cells are poorly understood. Primary cell cultures...
Migration and invasion are hallmarks of cancer cells that allow their dissemination to other tissues. Studying the cellular molecular basis cell migration can help us understand control metastasis. Many membrane molecules have been described as being involved in tumor migration, among them is cholesterol. In present study we investigated role cholesterol breast cells. The human mammary gland/breast epithelial line MDA-MB 231 was used depleted with methyl-β-cyclodextrin (MbCD). Cell measured...
Skeletal myogenesis comprises myoblast replication and differentiation into striated multinucleated myotubes. Agents that interfere with are important tools for the understanding of myogenesis. Recently, we showed cholesterol depletion by methyl-β-cyclodextrin (MCD) enhances step in chick-cultured myogenic cells, involving activation Wnt/β-catenin signaling pathway. However, effects on have not been carefully studied. Here show MCD treatment increases cell proliferation primary chick...
Hepatic stellate cells are intralobular connective tissue expressing the myofibroblast or lipocyte phenotypes. They participate in homeostasis of liver extracellular matrix, repair, regeneration, and fibrosis under former phenotype, control retinol metabolism, storage, release latter one. heterogeneous terms their distribution, function, expression cytoskeletal proteins. We have studied expressions intermediate filaments cloned GRX cell line representative murine hepatic cells, by...
In Laurencia dendroidea, halogenated secondary metabolites are primarily located in the vacuole named corps en cerise (CC). For chemical defence at surface level, these intracellularly mobilised through vesicle transport from CC to cell periphery for posterior exocytosis of chemicals. The structures involved this specific traffic as well cellular related positioning and anchoring within not known. Here, we aimed investigate role cytoskeletal elements both processes. Cellular molecular assays...
Myoblasts undergo major changes in their plasma membrane during the initial steps of skeletal muscle differentiation, including alterations distribution cholesterol. Cholesterol is involved crucial functions, such as fluidity, and permeability, organization specialized microdomains (or lipid rafts). We have previously shown that cholesterol levels myoblasts induce proliferation which involves activation Wnt/beta-catenin signaling pathway. In this study we used methyl-β-cyclodextrin (MbCD) to...