A5075407175- DNA Repair Mechanisms
- Cancer-related gene regulation
- Viral gastroenteritis research and epidemiology
- CRISPR and Genetic Engineering
- Vaccine Coverage and Hesitancy
- Radiation Therapy and Dosimetry
- Infectious Encephalopathies and Encephalitis
- PARP inhibition in cancer therapy
- Salmonella and Campylobacter epidemiology
- Vibrio bacteria research studies
- Stroke Rehabilitation and Recovery
- RNA modifications and cancer
- Bacterial Infections and Vaccines
- Infectious Diseases and Tuberculosis
- Mosquito-borne diseases and control
- Ethics in Clinical Research
- Acute Kidney Injury Research
- Protein Degradation and Inhibitors
- Peripheral Neuropathies and Disorders
- Pressure Ulcer Prevention and Management
- Neonatal and fetal brain pathology
- Epilepsy research and treatment
- Facial Nerve Paralysis Treatment and Research
- Child Nutrition and Water Access
- Cerebral Palsy and Movement Disorders
Vardhman Mahavir Medical College & Safdarjung Hospital
2021-2025
B.P. Koirala Institute of Health Sciences
2014-2024
Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital
2016-2021
Institute of Medical Sciences
2021
Post Graduate Institute of Medical Education and Research
2016-2018
Hammersmith Hospital
2003
In October, 2017, WHO launched a strategy to eliminate cholera by 2030. A primary challenge in meeting this goal is the limited global supply capacity of oral vaccine and worsening outbreaks since 2021. To help address current shortage vaccine, prequalified Euvichol-Plus was reformulated reducing number components inactivation methods. We aimed evaluate immunogenicity safety Euvichol-S (EuBiologics, Seoul, South Korea) compared with an active control Shanchol (Sanofi Healthcare India,...
Background Identification and preservation of the facial nerve trunk (FNT) are critical during parotidectomy to prevent complications such as paralysis. Due its anatomical proximity accessibility, posterior belly digastric muscle (PBDM) has emerged a consistent reliable intraoperative landmark for localizing FNT. This study aims review experience single institution in superficial parotidectomy, with focus on identifying FNT using PBDM. Methods retrospective observational reviewed 24 cases...
Hereditary spherocytosis (HS) is one of the most common hereditary haemolytic anaemia (HA) with variable clinical expression anaemia, splenomegaly and presence spherical cells called spherocytes due to mutations in rbcs membrane protein genes e.g. ANK1 (ankyrin), EPB42 (protein 4.2), SPTA1(α-spectrin), SPTB (β-spectrin) SLC4A1 (Band 3). There autosomal dominant inheritance 75% cases recessive 25% cases. We report a pair case mother male child; their samples for hemogram were simultaneously...
Osteopetrosis is a rare inherited metabolic bone disorder characterized by extensive sclerosis of skeletons, visual and hearing impairment, hepatosplenomegaly anemia. It has two major clinical forms: the autosomal dominant adult (benign) form associated with milder symptoms often appearing in later childhood adulthood whereas recessive infantile (malignant) severe presentations very early childhood, if untreated, typically fatal during infancy or childhood. A (intermediate) present some...
Typhoid fever is an endemic disease in many low-income and middle-income countries. The 2018 WHO position paper recommends that countries should consider typhoid vaccination high-risk groups for outbreak control. To address the vaccine supply demand gap, a Vi polysaccharide-diphtheria toxoid (Vi-DT) conjugate development effort was undertaken to achieve prequalification contribute global of vaccine. main aim this study show immune non-inferiority Vi-DT compared with prequalified...
The clinical spectrum of Cerebral palsy (CP) can differ in various places depending upon knowledge the people and resources for prevention, diagnosis management. Although studied extensively high-resource countries, adequate data related to CP from resource-constraint settings are lacking. This study aims describe profile children with at a tertiary care center eastern Nepal.This was hospital-based cross-sectional descriptive done 2017 2018. Children 6 months 15 years who presented were...
Bacterial meningitis is a paediatric emergency with high mortality and morbidity requiring prompt diagnosis treatment. Clinically, it often difficult to differentiate between bacterial non-bacterial meningitis. Several studies have demonstrated the raised values of serum procalcitonin (PCT) in infections including but without definite cut-off guidelines. Hence, this study was done evaluate PCT as marker children assess its efficacy. It cross-sectional over period 5 months (Aug 2016-Dec 2016)...
To investigate the clinical, laboratory, epidemiological profiles and outcome in human immunodeficiency virus infected Nepalese children. This was a hospital based prospective study. Human virus-infected children presenting to pediatric immunology clinic at BP Koirala Institute of Health Sciences were enrolled followed up. Median age diagnosis among 39 58 months. All acquired infection vertically. Unsafe sex (74.4%) intravenous drug use (25.6%) major risk behaviors fathers. At presentation,...
Clinical trials are complicated, time-consuming and costly. From the initial screening, informed consent recruitment of participants' to study completion, sponsor must undertake a wide array complex closely monitored operations, complying with international standards for human subject research local requirements. Conducting these studies in an underdeveloped country, limited resources, infrastructure, experience regulated clinical adds this complexity. The site selection, set up preparatory...
Typhoid remains one of the major serious health concerns for children in developing countries. With extremely drug-resistant cases emerging, preventative measures like sanitation and vaccination, including typhoid conjugate vaccines (TCV) remain mainstay its prevention control. Different types TCVs are being developed to meet global demand. This report outlines results from a study done assess immunogenicity safety Vi-Diphtheria toxoid (Vi-DT) TCV Nepal. The was randomized,...
Background: Basic Life Support (BLS) aims to maintain respiration and circulation in the cardiac arrest victim involves a major focus on cardiopulmonary resuscitation (CPR) with minimal use of ancillary equipment. The raised standards care demand that knowledge about BLS/ CPR be updated include lay persons as well medical experts who have potential become teachers skill. objective study was describe attitude personnel (nurses doctors) towards CPR.
 Methods: This cross sectional done...
A baby girl was born with severe deformity of left knee. Clinically and radiologically she diagnosed as congenital dislocation Gentle manipulation followed by above knee POP slab corrected the in three weeks. follow up at age 6 months showed normal position range motion We are reporting this case for its rarity. Early recognition requires simple intervention only.DOI: http://dx.doi.org/10.3126/jonmc.v1i1.7291 Journal Nobel Medical College Vol.1(1) 2011 68-70
Hypercalcemia is one of rare metabolic disorders associated with hyperparathyroidism, malignancy and various other causes. Although common in adult malignancies, hypercalcemia pediatrics purports poor prognosis. Nasopharyngeal carcinoma no reported hypercalcemic presentation. We present here a case child nasopharyngeal carcinoma. A 10 year girl presented backache for 1 month, epistaxis, cough, chest pain week alongwith anorexia weight loss. Investigations revealed anemia (23mg/dl; normal...
Infantile tremor syndrome (ITS) affects children aged 6-18 months, and is characterized by tremors, pallor, developmental regression, skin pigmentation changes, sparse hypopigmented hair. This case report highlights an ITS presentation in a 16-month-old exclusively breastfed male, emphasizing the significance of complementary feeding.
Introduction: Olanzapine, an atypical antipsychotic, is widely used for treating psychiatric conditions such as schizophrenia and bipolar disorder. Accidental overdose in children rare but can lead to severe clinical effects. This case report discusses the management of a 5-year-old male who accidently ingested 180 mg olanzapine, highest reported dose child around 5 year. Case presentation: A boy accidentally resulting loss consciousness central nervous system depression. He exhibited...
Clinical trials (CT) have been the cornerstones in developing medicines, vaccines, and new interventions. Despite tremendous efforts, a CT cannot succeed without participants' involvement. Various factors can affect people's attitude participation CT. Hence, this study was conducted to assess knowledge perception of clinical trial among participants at B.P. Koirala Institute Health Sciences, Dharan, Nepal. This population-based descriptive cross-sectional during 2021–2022. Participants...
Clinical trials are the most rigorous scientific and regulated method to investigate safety efficacy of vaccines or drugs in pre-licensure stage. trial design implementation complex, time-consuming involves close engagement with country's regulatory authority, clinical sites, investigators, healthcare system. Over past few decades, a significant number have been conducted low- middle-income countries (LMICs), particularly resource-limited settings. Conducting research LMICs leads capacity...
Background: Junk food and its effect has become major public health concern. There is a rapid increment in the intake of junk Nepal as result shown many negative consequences on Nepalese people mostly adolescents due to which they are prone have non-communicable diseases mental illnesses. This study aimed assess knowledge regarding among adolescents. Methods: A descriptive cross-sectional was conducted 230 studying government schools. Adolescents were selected by probability proportionate...