A5103142927- Protein purification and stability
- Marine and coastal ecosystems
- Microbial Natural Products and Biosynthesis
- Microfluidic and Capillary Electrophoresis Applications
- Marine Toxins and Detection Methods
- Fungal Biology and Applications
- Aquatic Ecosystems and Phytoplankton Dynamics
- Microbial Community Ecology and Physiology
- Microfluidic and Bio-sensing Technologies
- Soil and Water Nutrient Dynamics
- Photorefractive and Nonlinear Optics
- Viral Infectious Diseases and Gene Expression in Insects
- Pharmacological Effects of Natural Compounds
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- Protist diversity and phylogeny
- Marine Sponges and Natural Products
- Natural product bioactivities and synthesis
- Nonlinear Optical Materials Research
- Membrane Separation and Gas Transport
- Surface Roughness and Optical Measurements
- Advances in Cucurbitaceae Research
- Medicinal Plant Pharmacodynamics Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Bioactive natural compounds
Zhejiang University
2000-2024
Zhejiang Ocean University
2017-2024
Huzhou University
2024
Wuhan University of Technology
2023
Shanghai Tenth People's Hospital
2023
Tongji University
2023
Westlake University
2022
Jiangnan University
2020-2022
Changchun University of Chinese Medicine
2020-2022
Qingdao University
2017-2021
B7 molecules play significant roles in regulating tumor immunity, but their expression patterns and immuno-biological correlations pancreatic cancer (PaCa) have not been fully discussed.RNA-sequencing data of PaCa samples the Cancer Genome Atlas (TCGA) dataset was downloaded from UCSC Xena to assess expression, correlation, mutation family PaCa. Next, two tissue microarrays (TMAs, Cat. HPanA150CS02 HPanA120Su02) were obtained Outdo BioTech (Shanghai, China). To detect levels PD-L1, B7-H3...
Abstract Evolutionary adaptation could assist organisms to cope with environmental changes, yet few experimental systems allow us directly track evolutionary trajectory. Using evolution, tolerance Microcystis aeruginosa was investigated in two cladocerans ( Daphnia pulex and Simocephalus vetulus ) test the hypothesis that cladoceran grazers rapidly adapt toxic cyanobacteria. After exposure for either three or six months, both evolved a higher tolerance. The intrinsic rate of population...
Biopharmaceuticals are formulated using a variety of excipients to maintain their storage stability. However, some prone degradation during repeated use and/or improper storage, and the impurities generated by easily overlooked end users usually not strictly monitored, affecting stability biopharmaceuticals. In this study, we evaluated profile polyol excipient glycerol identified an unprecedented cyclic ketal impurity gas chromatography with mass spectrometry (GC-MS). The other excipient,...
Noncritical phase-matching (NCPM) fourth harmonic generation (FHG) of a 1053 nm laser was realized at room temperature on an ammonium dihydrogen phosphate (ADP), 35% deuterated DADP and 62% potassium (DKDP) crystals grown by point-seed rapid growth method. The NCPM is 33.7°C for ADP, 32.1°C DADP, 31°C DKDP crystal. temperature, angle tuning properties, performance in FHG ADP are calculated compared detail. 2ω-to-4ω conversion efficiency has been demonstrated up to 67% with crystal, 63.45%...
We examined foliar nitrogen (N) and phosphorus (P) stoichiometry of 3 wetland plants (Phalaris arundinacea, Miscanthus sacchariflorus, Carex brevicuspis) distributed along an elevation gradient in the Dongting Lake, China, how this is related to soil physico-chemical characteristics, elevation, flooding days. Plant samples were collected from lakeshore sites. Total N P concentrations six characteristics measured, addition P. arundinacea M. sacchariflorus had higher total than C. brevicuspis....
Long non-coding RNAs (lncRNAs) are longer than 200 nucleotides that function as regulatory factors in many human diseases, including cancer. However, majority of lncRNAs remain to be characterized. In this study, we characterized a novel lncRNA transcript, named UNC5B antisense RNA1 (UASR1). UASR1 is 647bp length consisting two exons. This an intron 1 unc-5 netrin receptor B (UNC5B) gene. breast cancer tissues, was upregulated. Ectopic expression promoted proliferation and clonogenic growth...
Abstract Dinophysis species are distributed worldwide and cause diarrheic shellfish poisoning (DSP). This paper documents the first successful culture of a (DAYS01) strain taken off Xiaoping Island, Yellow Sea, China. The was identified as acuminata Claparède & Lachmann by morphological phylogenetic analysis. effects temperature different Mesodinium prey on physiological toxigenic characteristics D. DAYS01 were also investigated. results showed that toxin concentration (toxin amount per...
Two new α-pyrones, fupyrones A and B (1 2) a biosynthetically related known α-pyrone, 4-methyl-5,6-dihydro-2H-pyran-2-one (3), were isolated from an endophytic fungus, Fusarium sp. F20, harbored in the stems of Chinese medicinal plant Mahonia fortunei. Their structures determined on basis spectroscopic data including MS NMR. The antibacterial efficacies compounds 1-3 evaluated against four selected Gram-positive Gram-negative bacteria, their quorum sensing inhibitory activity was also...
In the clinical application of freeze-dried highly concentrated omalizumab formulations, extensive visible bubbles (VBs) can be generated and remain for a long period time in reconstitution process, which greatly reduces use efficiency. It is necessary to understand forming breaking mechanism VBs key factor efficient safe administration biopharmaceutical injection. The effects different thermal treatments on volume stability omalizumab, mAb-1, mAb-2 were investigated. internal microvoids...
Lidar has the advantages of high accuracy, resolution, and is not affected by sunlight. It been widely used in many fields, such as autonomous driving, remote sensing detection, intelligent robots. However, current lidar detection system belongs to weak signal generally uses avalanche photoelectric detector units detectors. Limited technology, photosensitive surface small, receiving field view limited, it easy cause false alarms due background light. This paper proposes a method based on...
Fusidic acid, a representative member of fungal fusidane triterpenoids, has been clinically used as an antibiotic. In the present study, fusidic acid (1), and its known analogs 16-desacetylfusidic (2) 3β,20-dihydroxy-protosta-16,24-dien-29-oic (4), together with one new derivative acremonidiol A (3), were isolated from endophytic fungus, Acremonium pilosum F47. Their structures determined by MS NMR. The spectroscopic data 2 are firstly reported here. antibacterial efficacies 1-4 evaluated...
The development of Dinophysis populations, producers diarrhetic shellfish toxins, has been attributed to both abiotic (e.g., water column stratification) and biotic (prey availability) factors. An important process consider is mixotrophy the species, which an intensive feeding Mesodinium species for nutrients a benefit from kleptochloroplasts. During process, nutritional status in environment changes due preference and/or different nutrients, prey cell debris generated by sloppy feeding,...