A5061526373- Wound Healing and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Mesenchymal stem cell research
- Cardiac, Anesthesia and Surgical Outcomes
- Abdominal Surgery and Complications
- Electrospun Nanofibers in Biomedical Applications
- Hemodynamic Monitoring and Therapy
- Tendon Structure and Treatment
- Diabetic Foot Ulcer Assessment and Management
- Dysphagia Assessment and Management
- Pressure Ulcer Prevention and Management
- Radiomics and Machine Learning in Medical Imaging
- Facial Trauma and Fracture Management
- Surgical site infection prevention
- Bone fractures and treatments
- Breast Implant and Reconstruction
- Gastrointestinal Tumor Research and Treatment
- Tissue Engineering and Regenerative Medicine
- Diet and metabolism studies
- Colorectal Cancer Surgical Treatments
- COVID-19 and healthcare impacts
- Peripheral Nerve Disorders
- Breast Cancer Treatment Studies
- Elbow and Forearm Trauma Treatment
- Surgical Sutures and Adhesives
University of Pittsburgh
2023-2024
University of Arizona
2018-2024
Creative Commons
2023
Harvard University
2023
University of Pittsburgh Medical Center
2023
Virginia Commonwealth University
2023
Yuma Oncology Center
2018-2020
Regional Medical Center
2018-2020
Banner - University Medical Center Tucson
2020
Autologous fat grafting, or lipotransfer, is an important surgical approach to relocate adipose tissue within individual create volume. While used extensively in plastic and reconstructive surgery, significant drawbacks exist, including unpredictable volume retention. Thus, considerable research has been undertaken identify therapeutic approaches that improve outcomes, primarily utilizing a xenograft immunocompromised mouse model. Large animal models are step translating preclinical...
Situs inversus totalis is a rare congenital condition where organs are mirrored across the sagittal plane of body. In absence associated comorbidities, most people have normal health and lifespan. Challenges with image anatomy arise when needing an operative procedure involving intraabdominal organs. There few reported cases in literature laparoscopic surgery patients situs inversus, even fewer field bariatric surgery. Obesity obesity-related comorbidities continue to increase our society,...
Background Soft tissue defects with exposed avascular structures require reconstruction well-vascularized tissues. Extensive research is ongoing to explore engineered products that provide durable coverage. However, there a lack of controlled and affordable testbeds in the preclinical setting reflect this challenging clinical scenario. We aimed address gap literature develop feasible easily reproducible model rodents reflects an structure wound bed. Methods created 20 × mm full thickness...
Introduction Hand fractures are associated with significant morbidity. Current management standards often result in prolonged immobilization, stiffness, and delayed return to functional use. Intramedullary (IM) compression screws offer minimal soft tissue disruption early postoperative active motion. In this study, we describe our outcomes after intraosseous fracture fixation using IM cannulated headless for a multitude of patterns. Methods This study is retrospective review patients who...
Background Breast reconstruction methods vary based on factors such as medical history, breast size, and personal preferences. However, disparities in healthcare exist, the role race plays accessing to different is unclear. This study aimed investigate influence of and/or ethnicity type chosen. Methods retrospective cohort analyzed University Pittsburgh Medical Center Magee Women's Hospital database, including patients who underwent cancer surgery from 2011 2022. Multivariate analysis...
PURPOSE: Industry-supported research helped advance peripheral nerve surgery but raises concerns about conflict of interest. We asked: is there an association between industry payment to study authors and the reported outcomes after grafts conduits? METHODS: A systematic literature review was conducted Jan-2005 Sep-2023. Studies reporting 2-point discrimination, monofilament testing medical counsel scales for muscle strength repair with allograft or conduit were extracted. Study details...
PURPOSE: Pediatric facial fractures are a common cause of emergency department visits and hospital admissions. However, little has been published on the social determinants health for pediatric fractures. This study aims to investigate contribution socioeconomic status, race, education, household structure, English-language proficiency, insurance status management outcomes in fracture patients. METHODS: A retrospective review was performed patients under age 18 who were evaluated at level I...
A gastric diverticulum is a rare finding in which the wall of stomach forms an abnormal sac-like projection. Gastric diverticula can be problematic causing symptoms including but not limited to chronic gastroesophageal reflux, abdominal pain, and bloating. When becomes symptomatic, removal indicated. In specific cases, laparoscopic resection completed with concurrent bariatric surgery. We report perioperative approach used 34-year-old obese woman confirmed symptomatic undergoing sleeve gastrectomy.
Abstract Introduction Complex burns are a challenge, often requiring prolonged reconstruction. Management requires consideration not only to the skin but underlying structures and staged-reconstruction revision for increasingly unsatisfactory results. This standard is expensive, limited by donor-site availability, impacts quality of life. Here we demonstrate efficacy single-staged minced grafting in an incubator-like microenvironment with negative-pressure moist wound chamber device achieve...
BACKGROUND: There is a delicate balance between physiologic healing and formation of unfavorable scars. Homeostasis extracellular matrix (ECM) deposition remodeling maintained by an array inter-connected signaling networks with situationally-dependent functions. We previously demonstrated that systemic mineralocorticoid receptor (MR) inhibition improves epithelialization diminishes collagen without eroding scar strength. MR-inhibition, however, has range off-target effects when applied...
PURPOSE: Current fat grafting small animal xenograft models have demonstrated success in human tissue survival. Yet are challenging given the limitations of scale and adipose structure between different species, grafts' size, hosts' immunocompromised status limiting clinical relevance. There is thus a need for better large translational model capable sustaining localizing larger graft sites direct comparison to practice. The swine common skin subcutaneous tissues with record successful...
PURPOSE: Thermal burns to the face or extremities are highly morbid injuries risking severe disfigurement, functional and psychosocial impairment. These commonly require debridement prolonged staged reconstruction often with multiple grafts, flaps, need for delayed-touch ups. This standard-of-care is costly, time-consuming, deeply frustrating, puts patients at risk of extensive donor-site surgical complications. Currently there no simple, scalable, single-stage procedures available...
PURPOSE: Tendon injuries after trauma, or through use/disuse, degeneration are among the most frequent musculoskeletal lesions treated by plastic surgeons. The healing process and inflammatory response following injury is critical to direct remodeling allow for adequate slippage friction without adhesion. Adipose-derived stem cells (ASC) have been shown regulate multiple enhance rejuvenation of various tissues. In this study, we aimed create a novel model evaluate role ASCs in rodent tendon...
PURPOSE: Complex facial and extremity burns present a difficult challenge affecting skin contour, mobility, appearance. Management requires consideration not only to the skin, but patient's quality of life. Interventions often require stage-reconstruction, revision for increasingly unsatisfactory results burdensome dressing during healing. This standard is costly, limited by donor-site availability, morbid. Currently, there are no single-stage interventions with simple dressings address...
Abstract Introduction Complex burns are highly morbid injuries that can cause severe disfigurement and be devastating to one’s quality of life psychosocial well-being. Currently, there no simple, single-stage procedures available for extensive or multifocal address full-thickness trilaminar defects. Our team has previously demonstrated the viability an adipose-first reconstruction hypodermal In this study, we demonstrate efficacy a combined adipose plus finely minced skin achieve...
PURPOSE: A major limitation of fat grafting is unpredictable retention. We previously demonstrated that bioactive Vitamin D (VD3), calcitriol, improves human graft retention in a xenograft mouse model, however, high dose calcitriol incurs safety risks. Additionally, we have verified inactive VD3, cholecalciferol, similarly protects adipose stromal cell viability during vascular insufficiency post-grafting and long term porcine model. Within our overall goal defining clinical protocol for...
PURPOSE: Lower extremity (LE) wounds are costly and common sequelae of diabetes vascular disease. These patients may require multiple operative interventions to achieve healing, but some progress amputation. The 5-year mortality after major amputation in the diabetic foot ulcer population ranges from 40% 80%. current management paradigm for with non-healing emphasizes preservation limb length necessary salvage procedures rather than pursuing early amputation.1 However, critical assessment...